Ryan Jones is hoping to be available to face Edinburgh on Saturday following his latest injury set-back.
The Ospreys star has been troubled by a shoulder problem since Wales' RBS 6 Nations victory over Scotland.
He faced Benetton Treviso on the opening weekend of RaboDirect Pro12 action but was forced off and missed the tense draw with Leinster last week.
Jones made just nine starts for the Ospreys last season but he is looking forward to the region's return to the Liberty Stadium.
"Fingers crossed I'll get the nod from the medical team," said Jones.
"If I'm selected, it'll be great to get back out there in front of our home crowd at the Liberty Stadium.
"It's a fantastic venue and our supporters have shown time after time that they can create a wonderful atmosphere.
"I was disappointed not to be involved in Dublin. The RDS is a great place to play and we've enjoyed a good record there in recent seasons. It's one of the PRO12's great rivalries, and last weekend was another classic encounter between the teams.
"We're all looking forward to being back at home this weekend. It's week three and it's our first game at home. There's a huge appetite for it and the players, just as much as the fans, are looking forward to getting some game- time at the Liberty."
The Ospreys remain unbeaten this season, a stark contrast to last year where they lost their opening three league encounters.
Jones insists they have a long way to go but he reckons the fierce competition at the region will be hugely beneficial.
"The challenge we face as a squad now is to continue striving to improve," said Jones.
"We aren't the finished article based on two games. If we think we are, that's where we'll fall flat. We have to keep working hard.
"But we have been able to put in a fair bit of work this summer for the battles ahead. We've seen a few boys returning from injury and we've been bolstered by new faces coming in and players stepping up from age-grade. We're in a good place.
"It's hugely competitive here. We have huge strength in the back five and it's an achievement just to get a game for the Ospreys.
"Look who's been involved over the first few weeks: old heads like Joe Bearman have been excellent, while it's been great to have Tom Smith back after a year out with injury. He's been like a new signing. And, of course, we have youngsters like James King and Sam Lewis, who've been nothing short of exceptional.
"It's incredibly satisfying as someone who has been here a long time and cares passionately about this region to see players like that coming through, even if it makes life difficult for me.
"I'm still as competitive as I've ever been. I still have huge aspirations for this region to be successful and be a team that no- one likes to play against, domestically and in Europe. We are striving to be the best that we can be as a group."
The British & Irish Cup kicks off this weekend with the four Regional Premiership Select XVs flying the flag for Wales. Welsh
Sat 14 Nov: Blues Premiership Select v Nottingham (2.30) & Connacht Eagles v Dragons (2.30)
Sun 15 Nov: Yorkshire Carnegie v Ospreys Premiership Select (1.30) & Scarlets v Bedford Blues (3.00)
The Welsh Rugby Union is forming a new Youth Board with a brief to help keep more young people involved in the game during their late teenage years and beyond. The first task of the fifteen strong Board will be to analyse and consider the issues which lead to a number of youngsters drifting away from the sport between the ages of 16 and 21. To apply visit www.wru.wales/youthboard
The Foster's Challenge Cup will involve the 12 Principality Premiership sides and will run during European and British & Irish Cup weeks, providing vital fixtures for the participating clubs and an opportunity for upcoming players to step up to semi-professional rugby and make a claim for starting places within the Premiership squads.
Eighty schools and colleges in Wales now have a full time rugby officer as part of the WRU's school club hub scheme. All of the school club hub officers recently gathered at the National Centre of Excellence for various workshops.
With Liam Williams forced out of the World Cup through injury, lock Luke Charteris and Skills Coach Neil Jenkins say they have to put yesterday's defeat behind them as Wales now look ahead to another physical encounter against South Africa in the quarter-finals of the Rugby World Cup.
WRU Consultant Head of Physical Performance Paul Stridgeon praises the Physical Performance department for their work and dedication as he addresses the media ahead of Wales' Pool A clash against Australia
Twelve young people have been selected to follow a one year WRU Coach Core apprenticeship programme. Coach Core was set up by the Royal Foundation of the Duke and Duchess of Cambridge and Prince Harry as part of the Olympics legacy in 2012 and the Duke of Cambridge was on hand to meet the apprentices on their first day in the job. The programme has been funded by the Hunter Foundation.