The turning point of the Welsh campaign was arguably the second-half of that first game against Ireland when, after trailing 30-3, they launched a stirring comeback which laid the groundwork for victories in Paris, Rome and Edinburgh.
Wales (+1.0) are 11/10 in the handicap betting with Paddy Power, with the draw (1.0) trading at 18/1 and England (-1.0) at 10/11.
So, there's not much in it but the home side, urging fans to back them with the We Are One campaign, will fancy their chances after last year's 19-12 win at Twickenham sealed a 20th Triple Crown.
Wales need a seven-point victory to retain that title, and Paddy Power has odds of a victory of between 1-12 points at 17/10. But as England have won three times in six visits to the Millennium Stadium since 2000, a home win is far from guaranteed. It is 25/1 that they do enough and win by exactly seven points to clinch the crown in the most dramatic fashion.
The Welsh will be keen to lock down England danger man Manu Tuilagi who is 12/1 to score the first try on Saturday. And the Leicester centre, who steps into the cauldron of the Millennium Stadium for the first time, has warned fans: "We're going for the win - nothing more, nothing less."
Alex Cuthbert will be one of the key men leading the Welsh charge in the bubbling atmosphere. The winger is one of just three men with two tries in the tournament so far and he is 9/4 to add to that tally and cross the line at any time. He is 10/1 with Paddy Power to score the first try of the game.
Leigh Halfpenny's accuracy with the boot has been unmatched in this tournament and he leads the way in overall point scorers this year with 62. He has an 86 per cent conversion rate and a 79 per cent success rate with penalties from the first four games. Halfpenny is ice-cool under pressure and it is 6/4 that the first score of Saturday's game is a Wales penalty.
Whether the roof is shut or not, Paddy is odds-on that Saturday in Cardiff will be a cracker.