Bidding for their first Grand Slam since 2003, England have also recalled Ben Youngs in place of Danny Care.
The other changes to the England side seeTom Croft start at blindside flanker instead of James Haskell, while Joe Marler is back at prop for Mako Vunipola.
Victory for England would give them their first grand slam since their Rugby World Cup-winning year but they could still win their second championship in three years if they are beaten by fewer than eight points.
England A Goode (Saracens); C Ashton (Saracens), M Tuilagi (Leicester), B Barritt (Saracens), M Brown (Harlequins); O Farrell (Saracens), B Youngs (Leicester); J Marler (Harlequins), T Youngs (Leicester), D Cole (Leicester), J Launchbury (Wasps), G Parling (Leicester), T Croft (Leicester), C Robshaw (Harlequins, capt), T Wood (Northampton). Replacements: D Hartley (Northampton), D Wilson (Bath), M Vunipola (Saracens), C Lawes (Northampton), J Haskell (Wasps), D Care (Harlequins), T Flood (Leicester), B Twelvetrees (Gloucester).
You can follow every minute of the action between Wales and England at www.wru.co.uk/live just prior to kick-off.