Talismanic Italy skipper Sergio Parisse will miss Saturday's showdown against Wales after being suspended for 30 days.
Parisse will be free to play again on 18 March, after seeing red last weekend playing for his club Stade Francais against Bordeaux-Begles when he was dismissed for allegedly insulting match referee Laurent Cardona.
The ban, 40 days with 10 suspeneded, rules him out of Italy's remaining RBS 6 Nations games this season against Wales, England and Ireland.
The No 8 was sent off after 36 minutes of Stade's home match with Bordeaux-Begles, having scored a try in the fourth minute.
Italy coach Jacques Brunel had already called veteran flanker Mauro Bergamasco into his squad to face Wales.
As the countdown continues for RWC2015, Tournament Chief Executive Debbie Jevans visited the Millennium Stadium to discuss preparations for the eight matches and reveal the positive news that 100,000 tickets for games at the home of Welsh rugby have sold in the last seven days.
Jason Harries is targeting a first win on the World Series circuit this season with Wales. The series returns to action this weekend in Dubai where Harries is part of a team hoping to build from its efforts in round one in October.
Wales skipper Jevon Groves says his side have addressed a few points from Gold Coast and aim to 'hit the ground running' in the next two rounds of the World Series, kicking off with this weekend in Dubai before heading off to South Africa next week.
Wales Sevens manager Steff Thomas is hopeful his side can build from a quarter-final spot in the opening round of the World Series in Australia when his side take part in the forthcoming double header in Dubai and South Africa.