Talismanic Italy skipper Sergio Parisse will miss Saturday's showdown against Wales after being suspended for 30 days.
Parisse will be free to play again on 18 March, after seeing red last weekend playing for his club Stade Francais against Bordeaux-Begles when he was dismissed for allegedly insulting match referee Laurent Cardona.
The ban, 40 days with 10 suspeneded, rules him out of Italy's remaining RBS 6 Nations games this season against Wales, England and Ireland.
The No 8 was sent off after 36 minutes of Stade's home match with Bordeaux-Begles, having scored a try in the fourth minute.
Italy coach Jacques Brunel had already called veteran flanker Mauro Bergamasco into his squad to face Wales.
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GB7s women left their England base to train in Wales this week. Olympic Games hopeful Rachael Burford gives WRU TV's Graeme Gillespie her thoughts on Welsh teammate Jasmine Joyce - a 'one touch wonder'
The GB7s women's squad is currently training at Wales' Centre of Excellence where assistant coach Richie Pugh tells WRU TV's Graeme Gillespie some 'tough calls' will have to be made when it comes to finalising the 12 spots for Rio's Olympic Games.