Ashley Beck has been ruled out for six to eight weeks.
Wales and the Ospreys have been dealt a blow after Ashley Beck was ruled out for up to two months.
The centre suffered an ankle injury during his try-scoring cameo against Newport Gwent Dragons on New Year's Eve.
And following further investigation it has been discovered that the 22-year-old has suffered significant ligament damage.
He will subsequently miss the Ospreys crucial Heineken Cup matches with Leicester Tigers and Benetton Treviso and at least the first three fixtures of the RBS 6 Nations, against Ireland, France and Italy.
"Ashley suffered a significant ligament injury to his ankle during the New Year's Eve fixture at Rodney Parade," said Ospreys head of physio.
"We've conducted investigations over the course of the last week to determine the full extent of the ligament damage and plan his rehabilitation effectively.
"Based on the advice received, we are currently treating this as a 6-8 week injury so would expect to see him back in action by the end of February."
Jamie Roberts and Jon Davies remain the tried and tested combination in the Welsh midfield, while the likes of Scott Williams and James Hook offer further options.
UEFA has today confirmed the Football Association of Wales (FAW) has been successful in its bid for the Millennium Stadium to host the 2017 UEFA Champions League Final on Saturday 3rd June, 2017 (kick-off: 19.45hrs GMT).
The winners of a filmmaking competition organised by the education charity Into Film and the WRU enjoyed a behind the scenes tour of the Millennium Stadium - and a chance to be photographed with the WRU's fire-breathing, rugby loving mascot, Scorch The Dragon, and Welsh international, Jake Ball.
The Wales Under 20 camp are in a quietly confident mood as they face Ireland in the U20 Championship, with Coaching Co-Ordinator Allan Lewis and full back Dafydd Howells targeting a top five finish in the tournament.
Wales U20 may start as favourites against Japan this evening in the U20 Championship, but Team Manager Mark Taylor is warning against complacency. He is also hoping a good win will boost morale and 'kickstart' performances.
Coach Richard Hodges is hoping Wales U20 can put a disappointing campaign behind them when they tackle Japan tomorrow as they look to finish the U20 Championship strongly to secure a good seeding for next year's tournament.