The Ospreys are sweating on the fitness of star duo Ashley Beck and Justin Tipuric ahead of the crunch Heineken Cup clash with Leicester Tigers.
The Swansea-based region must maul the Tigers to keep their European hopes alive but could be without the international pair.
Beck is unlikely to recover from an ankle injury in time and Tipuric's chances are rated at 50/50.
"Tips is doing some rehab and is 50-50, but we are waiting on some extra information on Ashley Beck, who is a real doubt," said Ospreys head coach Steve Tandy.
"Tips has been huge for us, Becky, too. It something we've had to get used to this season, with senior players missing, people like Ian Evans, Alun Wyn Jones, Aaron Jarvis and Hanno Dirksen.
"If we lose Beck and Tips it will be a huge task for us, especially given the limited squad we have. But it's something we have to prepare for and we are going to give it a right old go."
Tandy was more hopeful of having Tipuric available for selection but he insists he will take no risks despite the magnitude of the game.
"There's always that temptation but we won't put the group before the player," said Tandy.
"If he's not right, he's not right. There are educated risks in what we are doing, but I need to sit down with the physio and see where they are come Friday.
Tom Issacs is set to fill the void left by Beck and Sam Lewis is a front-runner to start if Tipuric fails to recover.
And Tandy insists the Ospreys are confident of the duo coming in and producing the goods.
"We have no issues with TI (Isaacs) starting at 13 this weekend. He did really well for us there against the Scarlets earlier in the season.
"We'll weigh things up in the back-row, but we have a boy in Sam who's outstanding every time he wears the shirt.
"He was out on his feet at the end of the Zebre game, especially after his performance against the Dragons. He is developing all the time.
"You find out more about people on these big occasions and we are keen to develop from within. I know if Sam has to step into the role he won't let us down."
Beating Merthyr has boosted Carmarthen Quins hopes of reaching a top eight spot in the Principality Premiership. Quins captain Haydn Pugh is delighted with his team's progress and is determined that everyone from the Under 6s through to the senior team, enjoys the ride.
When the Wales squad were asked to nominate individuals who played a big part in their early playing days, Wales and Dragons full back and wing Hallam Amos thought of his former Monmouth School rugby coach John Bevan.
Sam Cross and Luke Treharne have been named as co-captains of the Wales Sevens side as head coach Gareth Williams names his 12-man squad to play in the first leg of the HSBC World Series in Dubai next weekend.
Bedwas head coach Steve Law and players Nicky Griffiths and Alun Rees extol the virtues of the close knit club as they prepare to host third place RGC 1404 - who are one place head of them on the Principality Premiership points table - on Saturday.
Many of the Wales squad have said Diolch (thank you) to someone who played an important part in their early playing days by nominating them to be invited to the Wales v South Africa match. One person, Gowerton Comprehensive geography teacher Mr Dean Mason was nominated by two of his former pupils, Dan Biggar and Sam Davies.
The second WRU disability rugby pilot has been delivered, this time in Caerphilly schools, culminating in a festival at the Caerphilly Centre of Sporting Excellence, Ystrad Mynach tomorrow. Plans are in place to set up a Disability Rugby Club in Newbridge to provide long-term playing opportunities.
WRU TV: Hear from inside the Wales camp as Neil Jenkins discusses this weekend's clash with South Africa and how the squad are looking to put in a strong performance to round of the 2016 Under Armour Series