Cross Keys travel West to take on Carmarthen Quins at the Parc on Saturday.
Greg Woods makes a total of six changes to the starting line-up from the side that started last week's home defeat to Bedwas.
Leon Andrews returns from injury and Richard Cornock has completed a suspension as Keys look to bounce back from three consecutive defeats against the inform Quins.
Carmarthen may have won four and lost four of their eight league games so far this season but they have enjoyed an impressive recent run, demolishing Swansea 41-17 in their league encounter last weekend.
Jason Harries bagged a hat-trick as the Quins' backs ran riot. Alex Pickersgill, Darren Daniel and Lee Williams added further scores whilst Jack Maynard kicked four conversions and a penalty.
With the injury situation slowly improving for Keys, they will be looking to bounce back and repeat last season's victory over the Quins.
Carmarthen captain Ian Jones returns from injury while Rhys Thomas is also back in contention.
Cross Keys: 15 Gareth David 14 Nathan Williams13 Leon Andrews 12 Luke Ford 11 Nathan Trowbridge 10 Dorian Jones 9 Rhys Dyer, 1 Richard Cornock 2 Garry Horrigan 3 Marc Jones 4 Danny Hodge 5 Tom Lampard 6 Rhys Peebles 7 Rob Nash (c) 8 Adam Powell. Replacements: Sean Higgins, Anthony Lott, James Johnstone, Jamie Sollis, Scott Matthews, Ryan James, Elliot Jones, Nathan, Luke Williams.
As the countdown continues for RWC2015, Tournament Chief Executive Debbie Jevans visited the Millennium Stadium to discuss preparations for the eight matches and reveal the positive news that 100,000 tickets for games at the home of Welsh rugby have sold in the last seven days.
Jason Harries is targeting a first win on the World Series circuit this season with Wales. The series returns to action this weekend in Dubai where Harries is part of a team hoping to build from its efforts in round one in October.
Wales skipper Jevon Groves says his side have addressed a few points from Gold Coast and aim to 'hit the ground running' in the next two rounds of the World Series, kicking off with this weekend in Dubai before heading off to South Africa next week.
Wales Sevens manager Steff Thomas is hopeful his side can build from a quarter-final spot in the opening round of the World Series in Australia when his side take part in the forthcoming double header in Dubai and South Africa.