Cross Keys travel West to take on Carmarthen Quins at the Parc on Saturday.
Greg Woods makes a total of six changes to the starting line-up from the side that started last week's home defeat to Bedwas.
Leon Andrews returns from injury and Richard Cornock has completed a suspension as Keys look to bounce back from three consecutive defeats against the inform Quins.
Carmarthen may have won four and lost four of their eight league games so far this season but they have enjoyed an impressive recent run, demolishing Swansea 41-17 in their league encounter last weekend.
Jason Harries bagged a hat-trick as the Quins' backs ran riot. Alex Pickersgill, Darren Daniel and Lee Williams added further scores whilst Jack Maynard kicked four conversions and a penalty.
With the injury situation slowly improving for Keys, they will be looking to bounce back and repeat last season's victory over the Quins.
Carmarthen captain Ian Jones returns from injury while Rhys Thomas is also back in contention.
Cross Keys: 15 Gareth David 14 Nathan Williams13 Leon Andrews 12 Luke Ford 11 Nathan Trowbridge 10 Dorian Jones 9 Rhys Dyer, 1 Richard Cornock 2 Garry Horrigan 3 Marc Jones 4 Danny Hodge 5 Tom Lampard 6 Rhys Peebles 7 Rob Nash (c) 8 Adam Powell. Replacements: Sean Higgins, Anthony Lott, James Johnstone, Jamie Sollis, Scott Matthews, Ryan James, Elliot Jones, Nathan, Luke Williams.
Carmarthen Quins are holding an exhibition to commemorate club players who fought in World War I. All welcome to the clubhouse on Friday afternoon to learn more about local history, or share any family anecdotes or artifacts.
Defence coach Shaun Edwards believes Saturday's clash against England - the 'form team in world rugby' - poses a huge challenge for his side but he is confident, with Wales beginning to show the defensive qualities displayed in the last two World Cups,
Women in the Ospreys region recently completed a Level 1 coaching course and are looking forward to putting their theory into practice in clubs and schools across the region. A women only course has been organised for the Scarlets region starting next week, full details at the end of the video.