Cross Keys travel West to take on Carmarthen Quins at the Parc on Saturday.
Greg Woods makes a total of six changes to the starting line-up from the side that started last week's home defeat to Bedwas.
Leon Andrews returns from injury and Richard Cornock has completed a suspension as Keys look to bounce back from three consecutive defeats against the inform Quins.
Carmarthen may have won four and lost four of their eight league games so far this season but they have enjoyed an impressive recent run, demolishing Swansea 41-17 in their league encounter last weekend.
Jason Harries bagged a hat-trick as the Quins' backs ran riot. Alex Pickersgill, Darren Daniel and Lee Williams added further scores whilst Jack Maynard kicked four conversions and a penalty.
With the injury situation slowly improving for Keys, they will be looking to bounce back and repeat last season's victory over the Quins.
Carmarthen captain Ian Jones returns from injury while Rhys Thomas is also back in contention.
Cross Keys: 15 Gareth David 14 Nathan Williams13 Leon Andrews 12 Luke Ford 11 Nathan Trowbridge 10 Dorian Jones 9 Rhys Dyer, 1 Richard Cornock 2 Garry Horrigan 3 Marc Jones 4 Danny Hodge 5 Tom Lampard 6 Rhys Peebles 7 Rob Nash (c) 8 Adam Powell. Replacements: Sean Higgins, Anthony Lott, James Johnstone, Jamie Sollis, Scott Matthews, Ryan James, Elliot Jones, Nathan, Luke Williams.
The annual Women's club launch was held at the Wales Centre of Excellence where National Women's Head Coach and Programme Lead Rhys Edwards, Competition Secretary Adrian Howell and Cardiff Met player Ffion Jones express eagerness for the new campaign to get under way.
WRU TV follows Wales' RWC training squad on day one of their camp in North Wales. The squad were greeted to an official welcome in Colwyn Bay and then headed for an afternoon of team building at ZipWorld