With Macauley Cook and Dan Fish involved for Cardiff Blues in their clash with Munster, Martyn Fowler makes a number of changes.
In the backs, Gareth Davies again starts at fly-half. After passing 1000 points for Cardiff last weekend, he will be looking to add to that tally. Richard Smith comes into the centre and is replaced on the wing by Steve Cullen. Will Thomas moves to fullback to fill the gap left by Fish's move up to the Blues.
For Neath, Prop Nicky Downs leads the side after regular skipper Gareth Gravell was involved in a motor accident earlier in the week. He is likely to miss a couple of games, compounding the Welsh All Blacks' injury problems.
Elsewehere, it is all change in the back-row where Lee Evans, Rhys Jones and Matthew Rees all start. Lee Williams comes into the second row and Elliot Jones plays on the wing with Chris Morgans reverting to scrum-half.
"We were far from our best last week but still created sufficient chances to have at least shared the spoils with Bridgend," said Neath Coach Patrick Horgan.
"Our preparations have been hit by injuries and flu in the camp but we are looking for all-round improvement against Cardiff."
Cardiff: 15 Will Thomas 14 Shaun Powell 13 Richard Smith 12 Max Woodward 11 Steve Cullen 10 Gareth Davies 9 Sion Hopkins, 1 Nathan Trevett 2 Aaron Fowler 3 Simon Gardiner 4 Alwyn Lee 5 Matthew Screech 6 Ben Roach 7 Ellis Jenkins 8 Dan Crimmins.
Replacements: Callum Lewis, Jac Hopkins, Willgriff John, Nick White, Reuben Tucker, Garyn Lucas , Joe Griffin, Darren Ryan.
Neath: 15 Aaron Bramwell 14 Kevin James 13 Ryan John Evans 12 Kyle Davies 11 Elliot Jones 10 David Langdon 9 Christopher William, 1 Nicky Downs 2 Rhodri Clancy 3 Thomas Price 4 Euros Evans 5 Lee Williams 6 Lee Evans 7 Matthew Rees 8 Dafydd Jones.
Replacements: Owain Ford, Aled Williams, Jonothan Griffiths, Leon Ward, Luc Jones, Jonathan Davies, Ben Jones.