Jason Harries' Quins side will face a Cardiff side looking to bounce back from defeat last weekend.
After a disappointing home defeat to Llandovery on the opening weekend of the season, Cardiff travel to Carmarthen Park on Saturday looking to get back on track.
Head Coach Martyn Fowler makes several changes to the side for the clash with Carmarthen Quins as he seeks a first win of the season.
Able to call on several of the Blues squad now that pre-season fixtures are finished, there are returns for former Blue and Black captain Macauley Cook, Cory Allen and Will Griff John.
Joe Griffin, who made an impact after moving from fullback to halfback last week, starts at ten alongside Rob Lewis. Cory Allen reforms his partnership with Richard Smith in the centre and exciting fullback Will Thomas is given his first Premiership start.
Up front Campese Ma'afu continues in the front row with James Murphy coming up from the bench to start in the second row. Macauley Cook fits into a new back row combination on the blind-side, with Ellis Jenkins moving to No 8 to allow Thomas Young to start on the open-side.
Cardiff: 15 Will Thomas 14 Will Jones 13 Richard Smith 12 Cory Allen 11 Steve Cullen 10 Joe Griffin 9 Rob Lewis, 1 Lewis Smout 2 Aaron Fowler 3 Campese Ma'afu 4 James Murphy 5 Matthew Screech 6 Macauley Cook 7 Thomas Young 8 Ellis Jenkins.
Replacements: Ethan Lewis, Will Griff John, Callum Lewis, Reuben Tucker, Dan Partridge, Alex Walker, Shaun Powell, James Thomas.
RGC 1404 have celebrated their crowning as Division One East winners, after just one season of competitive rugby. A big crowd turned out to support the clubs 'Celebration Saturday' when they were presented with the SWALEC trophy following their definitive 45-0 home win against Rhydydfelin on 18 May.
A special video package as Pontypridd claimed the double for the first time in their history by winning the Principality Premiership final, including match build-up, highlights, post match reaction and dressing room celebrations.
Ex-international rugby player Matthew J Watkins has, unfortunately, developed a very rare form of cancer of his right pelvis which requires treatment at Velindre Cancer Centre in Cardiff. He remains well and active and is supported by his friends and family.