The Wallabies suffered a shock 9-6 defeat to Scotland in Newcastle with the Kiwi coach reacting swiftly by making a raft of changes.
The Australian scrum was under pressure throughout against the Scots which has forced Deans to install an all-Waratahs front-row of Sekope Kepu, Tatafu Polota-Nau and Benn Robinson.
Second row Rob Simmons and No 8 Wycliff Palu also return to the starting line-up with Scott Higginbotham moving to the blindside to accommodate Palu's return.
Deans has also re-shuffled his backline, including Adam Ashley-Cooper at full-back and partnering Rob Horne and Pat McCabe in the centres.
The Wallabies beat Wales 24-18 in Cardiff in December and have won eight of the nine Tests played in Australia.
Australia: A Ashley-Cooper (NSW Waratahs); C Vuna (Melbourne Rebels) (Brumbies), R Horne (NSW Waratahs), P McCabe (Brumbies), D Ioane (Queensland Reds); B Barnes (NSW Waratahs), W Genia (Queensland Reds); B Robinson (NSW Waratahs), T Polota Nau (NSW Waratahs), S Kepu (NSW Waratahs), R Simmons (Queensland Reds), N Sharpe (Western Force), S Higginbotham (Queensland Reds), D Pocock (captain, Western Force), W Palu (NSW Waratahs).
Replacements: S Moore (Brumbies), B Alexander (Brumbies), D Dennis (NSW Waratahs), M Hooper (Brumbies), N White (Brumbies), A Fainga'a (Queensland Reds), M Harris (Queensland Reds).
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