Evie Jones was next on the scoresheet before Wrigley touched down again, before Gogleed Cymru hit back through stand-in player Cerys Ballett
But it proved a brief respite as Jones raced over for her second try but Wrigley was not to be outdone as she scored her third try of the first half to bring the score to 27-5 at the break.
Within a minute of the re-start centre Gaby French crossed for another Blues try before Ballett scored her second try of the match for the visitors.
Powerhouse Bronnie Jones (2), Wrigley, Megan Daley, Evie Jones and sister Bronnie Jones, Jenny Collins and Cerys Ballett, who came back to the Blues side completed the job with further tries.
A delighted Blues team manager Alan Roberts said: "It will be sad to see some of the girls leave the squad, but no doubt they will continue to play senior rugby whether for their home clubs, region or national squads, the Blues coaches wish them well."
Blues Scorers: Tries - Rebecca Wrigley (4), Evie Jones (3), Bronnie Jones (2), Gaby French, Megan Delay, Jenny Collins, Cerys Ballett; Cons: Joanne Jones, Jess Pritchard (3).
Gogledd Cymru: Tries - Cerys Ballett (2).