Wales kicking coach Neil Jenkins is hopeful that Jamie Roberts will overcome a knee injury to be in contention to face Italy.
Roberts hobbled out of the Twickenham Triple Crown victory over England at half-time with damaged medial ligaments.
But the star centre is making good progress as he battles to return to full fitness.
"We're waiting to find out more on Jamie, but it will probably be touch and go for the Italy game," said Jenkins.
"He's progressing really well, rehabbing very well at this moment in time, so fingers crossed, he could well make that game."
Wales are set to welcome back Matthew Rees and James Hook for the Millennium Stadium clash with the Azzurri but Huw Bennett remains a major doubt.
Rees failed to recover in time from a calf injury to face the old enemy but is back in full training and is aiming to make his first Six Nations appearance of the year following an injury-ravaged six-months.
Hook remains with Perpignan in France but has overcome his bout of chicken pox and is set to feature in the Top 14 clash with Agen before returning to Wales.
"Smiler is also back training, so there's good news on that front," added Jenkins.
"He's back with us, so hopefully he'll be back and available for selection.
"Hooky is also going to be back to full fitness. I think he'll be involved for Perpignan this weekend and if he comes through that unscathed he'll be involved with us next week and the game after."
Wales remain unbeaten in the Championship and face Italy on March 10, in the penultimate match before a potential Grand Slam decider with France.
Jenkins insists Wales' only focus is on the clash with Italy and expects a difficult encounter.
"We have a very tough game with Italy a week on Saturday and are not looking beyond that. If we can win it would set us up for a Grand Slam game with France, but we are looking at things one game at a time.
"Italy are always strong and will be strong up front this time. They are going to come and play, have a tough physical game and will want to take us on in the set-piece.
"They caused Ireland problems into the second-half last weekend and they should have beaten England at home. We know it's going to be a very tough afternoon for us, but we'll look forward to it.
"I'm expecting them to come here with four wins from their four games. England and Ireland will be tough for them, but France are at home and you'd expect them to win those games and hopefully come to Cardiff for a Grand Slam decider.
"But we have to just focus on ourselves and make sure we beat Italy."
Beating Merthyr has boosted Carmarthen Quins hopes of reaching a top eight spot in the Principality Premiership. Quins captain Haydn Pugh is delighted with his team's progress and is determined that everyone from the Under 6s through to the senior team, enjoys the ride.
When the Wales squad were asked to nominate individuals who played a big part in their early playing days, Wales and Dragons full back and wing Hallam Amos thought of his former Monmouth School rugby coach John Bevan.
Sam Cross and Luke Treharne have been named as co-captains of the Wales Sevens side as head coach Gareth Williams names his 12-man squad to play in the first leg of the HSBC World Series in Dubai next weekend.
Bedwas head coach Steve Law and players Nicky Griffiths and Alun Rees extol the virtues of the close knit club as they prepare to host third place RGC 1404 - who are one place head of them on the Principality Premiership points table - on Saturday.
Many of the Wales squad have said Diolch (thank you) to someone who played an important part in their early playing days by nominating them to be invited to the Wales v South Africa match. One person, Gowerton Comprehensive geography teacher Mr Dean Mason was nominated by two of his former pupils, Dan Biggar and Sam Davies.
The second WRU disability rugby pilot has been delivered, this time in Caerphilly schools, culminating in a festival at the Caerphilly Centre of Sporting Excellence, Ystrad Mynach tomorrow. Plans are in place to set up a Disability Rugby Club in Newbridge to provide long-term playing opportunities.
WRU TV: Hear from inside the Wales camp as Neil Jenkins discusses this weekend's clash with South Africa and how the squad are looking to put in a strong performance to round of the 2016 Under Armour Series