Wales kicking coach Neil Jenkins is hopeful that Jamie Roberts will overcome a knee injury to be in contention to face Italy.
Roberts hobbled out of the Twickenham Triple Crown victory over England at half-time with damaged medial ligaments.
But the star centre is making good progress as he battles to return to full fitness.
"We're waiting to find out more on Jamie, but it will probably be touch and go for the Italy game," said Jenkins.
"He's progressing really well, rehabbing very well at this moment in time, so fingers crossed, he could well make that game."
Wales are set to welcome back Matthew Rees and James Hook for the Millennium Stadium clash with the Azzurri but Huw Bennett remains a major doubt.
Rees failed to recover in time from a calf injury to face the old enemy but is back in full training and is aiming to make his first Six Nations appearance of the year following an injury-ravaged six-months.
Hook remains with Perpignan in France but has overcome his bout of chicken pox and is set to feature in the Top 14 clash with Agen before returning to Wales.
"Smiler is also back training, so there's good news on that front," added Jenkins.
"He's back with us, so hopefully he'll be back and available for selection.
"Hooky is also going to be back to full fitness. I think he'll be involved for Perpignan this weekend and if he comes through that unscathed he'll be involved with us next week and the game after."
Wales remain unbeaten in the Championship and face Italy on March 10, in the penultimate match before a potential Grand Slam decider with France.
Jenkins insists Wales' only focus is on the clash with Italy and expects a difficult encounter.
"We have a very tough game with Italy a week on Saturday and are not looking beyond that. If we can win it would set us up for a Grand Slam game with France, but we are looking at things one game at a time.
"Italy are always strong and will be strong up front this time. They are going to come and play, have a tough physical game and will want to take us on in the set-piece.
"They caused Ireland problems into the second-half last weekend and they should have beaten England at home. We know it's going to be a very tough afternoon for us, but we'll look forward to it.
"I'm expecting them to come here with four wins from their four games. England and Ireland will be tough for them, but France are at home and you'd expect them to win those games and hopefully come to Cardiff for a Grand Slam decider.
"But we have to just focus on ourselves and make sure we beat Italy."
Principality Stadium will host the UEFA Champions League Final in six weeks' time. WRU chairman Gareth Davies, Football Association of Wales chief executive Jonathan Ford and Ambassador Ian Rush joined young sports fans at the trophy arrival at the venue to celebrate the magnitude of the event on Saturday 3rd June (kick-off 19.45).
British and Irish Lions captain Sam Warburton is looking forward to bringing together players from Ireland, Scotland, England and Wales for the biggest challenge of their careers - a series against world champions, New Zealand.
For the fifth year running, Wales referee Nigel Owens will be in charge of proceedings at Judgement Day V at Principality Stadium. It promises to be 'extra special' for the Wales' favourite ref, as he will be making his 150th appearance in the league.
There will be no shortage of inside knowledge from Bowl Finalists Caerphilly and Amman United when they face each other on Sunday at National Finals Day. Caerphilly hooker Rhys Cleverly knows the Principality Stadium pitch better than most as a matchday groundsman, while Amman United can look to Wales' record try scorer Shane Williams for some helpful advice.
Two hundred and 40 teams competed in the inaugural Urdd WRU 7s held at Pencoed last week with Welsh internationals Steff Andrews and Jasmine Joyce impressed with the talent on display, as was Urdd chief executive, Sioned Hughes.
The countdown is on for Judgement Day V as tickets for the big day at Principality Stadium soar through the 50,000 mark. Players and coaches alike are bursting at the seams to play in the double header with Dragons coach Kingsley Jones claiming there is a 'real buzz' about the event.
WRU TV went behind the scenes when the four regions got together to test their skill set for the BBC's Scrum V Live rugby show, at the WRU National Centre of Excellene in the build up to Judgement Day V. Blues' Matthew Morgan was one of the stars of the show while the Dragons' Cory Hill proved a surprise package...the full set of results will be revealed on tv screens on matchday
Wales assistant coach Richie Pugh is confident his side can cause a few headaches in the Hong Kong Sevens this weekend. In a tough group, Wales kick off their campaign against New Zealand on Friday before playing Japan and Fiji, who are chasing their third consecutive Hong Kong title, on Saturday.
Bedwas had to overcome a stubborn Carmarthen Quins side before winning the Foster's Challenge Cup final in Bridgend with a 23-18 victory. Bedwas captain Nicky Griffiths pays tribute to his side who have claimed the club's first piece of silverware in the modern era.
Team coach Brett Davey is aiming to keep his unbeaten run in cup finals at Principality Stadium intact when his side take on Amman United in the WRU Bowl final, after he guided Caerphilly to a 20-14 win against Cilfynydd in the semi-finals.
Penallta are hoping to go one step further than last season when falling to Bedlinog in the WRU Plate Final. After a titanic struggle against Nant Conwy, they have given themselves a great chance, after a hard fought 18-13 semi-final victory.