Wales kicking coach Neil Jenkins is hopeful that Jamie Roberts will overcome a knee injury to be in contention to face Italy.
Roberts hobbled out of the Twickenham Triple Crown victory over England at half-time with damaged medial ligaments.
But the star centre is making good progress as he battles to return to full fitness.
"We're waiting to find out more on Jamie, but it will probably be touch and go for the Italy game," said Jenkins.
"He's progressing really well, rehabbing very well at this moment in time, so fingers crossed, he could well make that game."
Wales are set to welcome back Matthew Rees and James Hook for the Millennium Stadium clash with the Azzurri but Huw Bennett remains a major doubt.
Rees failed to recover in time from a calf injury to face the old enemy but is back in full training and is aiming to make his first Six Nations appearance of the year following an injury-ravaged six-months.
Hook remains with Perpignan in France but has overcome his bout of chicken pox and is set to feature in the Top 14 clash with Agen before returning to Wales.
"Smiler is also back training, so there's good news on that front," added Jenkins.
"He's back with us, so hopefully he'll be back and available for selection.
"Hooky is also going to be back to full fitness. I think he'll be involved for Perpignan this weekend and if he comes through that unscathed he'll be involved with us next week and the game after."
Wales remain unbeaten in the Championship and face Italy on March 10, in the penultimate match before a potential Grand Slam decider with France.
Jenkins insists Wales' only focus is on the clash with Italy and expects a difficult encounter.
"We have a very tough game with Italy a week on Saturday and are not looking beyond that. If we can win it would set us up for a Grand Slam game with France, but we are looking at things one game at a time.
"Italy are always strong and will be strong up front this time. They are going to come and play, have a tough physical game and will want to take us on in the set-piece.
"They caused Ireland problems into the second-half last weekend and they should have beaten England at home. We know it's going to be a very tough afternoon for us, but we'll look forward to it.
"I'm expecting them to come here with four wins from their four games. England and Ireland will be tough for them, but France are at home and you'd expect them to win those games and hopefully come to Cardiff for a Grand Slam decider.
"But we have to just focus on ourselves and make sure we beat Italy."
Wales Under 18 captain Callum Bradbury is delighted to have seen his side claim a narrow 18-17 victory against a strong SA Schools 'A' side to end the three-match Under 19 International Series in South Africa on a high note.
The Wales U18 squad spent an emotional day in the drug-riddled townnship of Hout Bay. Hout Bay Warriors President Fred Johannes said the visit was 'the talk of the town' and will dream about the day everyday for the rest of his life.
RGC 1404's new head coach Mark Jones is hoping to build 'something special' in north Wales and is already looking forward to the development region participating in the Principality Premiership for the very first time.
A joint venture between the WRU and Admiral saw hundreds of children enjoy the Admiral Festival of Rugby held at the National Centre of Excellence at the weekend where Welsh internationals Sam Warburton, Scott Williams and Rob Evans were in attendance.
Wll Jones leads Wales U18s into battle this afternoon against Italy where the Welsh side will be seeking to bounce back from their narrow defeat to SA Schools in their opening clash of the U19 International Series
All four regions attended a successful training camp staged last weekend at the WRU National Centre of Excellence. It was a chance for new Wales Women's head coach Rowland Phillips to deliver his key messages to players and coaches as he prepares for the new season.
Wales U18 Team Manager Gethin Watts believes the next couple of weeks will be 'extremely beneficial' to the future of Welsh rugby as his side prepare to take part in the Under 19 International Series being staged in South Africa.
The WRU is searching for 12 new rugby development apprentices following a successful first year of its WRU Coach Core programme. Craig Duncan and Jess Hancock have flourished in the first year of the programme which has given them a real direction in their lives.
The WRU signed TV comedian Rhod Gilbert up to a 'Coaching Children Level 1' course before letting him loose on an U8s side at Whitland Junior Borderers - we went behind the scenes to film the making of 'Rhod Gilbert's Work Experience' see the results here.
Llandovery are aiming to make it three titles in a row in this year's Foster's National 7s being held at BT Sport Cardiff Arms Park on Sunday 28 August. Drovers assistant coach Simon Davies and Lee Rees assess their sides chances
A pioneering strength and conditioning programme has been delivered to more than 8000 boys and girls at hub schools throughout Wales this season, helping to develop stronger, more flexible athletes for rugby and other sports.
The Singha Premiership Rugby 7s Series returns to the BT Sport Cardiff Arms Park on July 22nd when all four Welsh regions go head to head. Scarlets skills coach Dai Flanagan and Blues Elite Performance Pathway Manager Richard Hodges along with current Welsh squad members were at the launch of this season's event