Wales kicking coach Neil Jenkins is hopeful that Jamie Roberts will overcome a knee injury to be in contention to face Italy.
Roberts hobbled out of the Twickenham Triple Crown victory over England at half-time with damaged medial ligaments.
But the star centre is making good progress as he battles to return to full fitness.
"We're waiting to find out more on Jamie, but it will probably be touch and go for the Italy game," said Jenkins.
"He's progressing really well, rehabbing very well at this moment in time, so fingers crossed, he could well make that game."
Wales are set to welcome back Matthew Rees and James Hook for the Millennium Stadium clash with the Azzurri but Huw Bennett remains a major doubt.
Rees failed to recover in time from a calf injury to face the old enemy but is back in full training and is aiming to make his first Six Nations appearance of the year following an injury-ravaged six-months.
Hook remains with Perpignan in France but has overcome his bout of chicken pox and is set to feature in the Top 14 clash with Agen before returning to Wales.
"Smiler is also back training, so there's good news on that front," added Jenkins.
"He's back with us, so hopefully he'll be back and available for selection.
"Hooky is also going to be back to full fitness. I think he'll be involved for Perpignan this weekend and if he comes through that unscathed he'll be involved with us next week and the game after."
Wales remain unbeaten in the Championship and face Italy on March 10, in the penultimate match before a potential Grand Slam decider with France.
Jenkins insists Wales' only focus is on the clash with Italy and expects a difficult encounter.
"We have a very tough game with Italy a week on Saturday and are not looking beyond that. If we can win it would set us up for a Grand Slam game with France, but we are looking at things one game at a time.
"Italy are always strong and will be strong up front this time. They are going to come and play, have a tough physical game and will want to take us on in the set-piece.
"They caused Ireland problems into the second-half last weekend and they should have beaten England at home. We know it's going to be a very tough afternoon for us, but we'll look forward to it.
"I'm expecting them to come here with four wins from their four games. England and Ireland will be tough for them, but France are at home and you'd expect them to win those games and hopefully come to Cardiff for a Grand Slam decider.
"But we have to just focus on ourselves and make sure we beat Italy."
Porthcawl recently received a WRU facilities grant and funding from Natwest RugbyForce in order to give their changing rooms a facelift. This came after receiving £10,000 in a WRU facilities grant last year to tarmac their car park. The improvements have already helped to make the club more accessible, not only for their own members and players but for the whole community.
The Welsh Rugby Union has launched a new, accredited Safeguarding and Protecting Children course - funded by the WRU and delivered in partnership with Sport Wales and the NSPCC - fo rugby club volunteers around Wales.
The SWALEC semi-final draws threw up some mouth-watering clashes in the Cup, Plate and Bowl as the 12 teams aim for the Millennium Stadium Finals Day. All the semi-finals are to be played on the weekend of April 12.
Welsh whistler Rhys Thomas continues to scale the heights of the game as he prepares to be an official in this weekend's Hong Kong Sevens tournament, undoubtedly the showpiece event on the World Series calendar.
Wales International Ian Evans and Wales and Lions legend Scott Quinnell swapped rugby balls for paint pots at Tonna during the RBS 6 Nations. They surprised club players with a special clubhouse makeover to launch NatWest RugbyForce 2014 - a programme developed in partnership with the WRU to make rugby clubs stronger businesses by improving and renovating their facilities with the support of volunteers and the local community.
Fresh from claiming the Bowl honours in Tokyo last Sunday, the Wales Sevens squad have settled into their routine as they prepare for this weekend's Hong Kong tournament where Iolo Evans is aiming high, as WRU TV's Graeme Gillespie discovers.
The Welsh Rugby Union has recently teamed up with Prostate Cymru to help the charity launch its latest campaign to raise awareness of the disease. Members of the Wales squad helped produce a short video and promotional material for the campaign titled 'The Best Defence - is to know the FACTS'.