On the bench, a trio of uncapped players have been called-up, Ed Kalman, 20-year-old stand-off Duncan Weir and 19-year-old full-back Stuart Hogg.
Scotlandwill be looking for their first victory over Wales in the 6 Nations since 2007 this weekend and Robinson believes it's the right time to blood youth.
"Congratulations to Greig on his first start. He is a gifted footballer who is acclimatising very well to the differing demands of the stand-off position from having spent most of his career at scrum-half," said Robinson.
"Having lost last weekend, I believe the time is right to move on and look to develop our emerging talent at stand-off.
"I've always stressed the importance of the A team and the part that both Duncan Weir and Stuart Hogg played in the game at Netherdale last week is another reason for my continued excitement and belief in Scottish rugby."
15 Rory Lamont (Glasgow Warriors)
14 Lee Jones (Edinburgh Rugby)
13 Nick De Luca (Edinburgh Rugby)
12 Sean Lamont (Scarlets)
11 Max Evans (Castres)
10 Greig Laidlaw (Edinburgh Rugby)
9 Chris Cusiter (Glasgow Warriors)
1 Allan Jacobsen (Edinburgh Rugby)
2 Ross Ford (Edinburgh Rugby) CAPTAIN
3 Geoff Cross (Edinburgh Rugby)
4 Richie Gray (Glasgow Warriors)
5 Jim Hamilton (Gloucester)
6 Alasdair Strokosch (Gloucester)
7 Ross Rennie (Edinburgh Rugby)
8 David Denton (Edinburgh Rugby)
16 Scott Lawson (Gloucester)
17 Ed Kalman (Glasgow Warriors)
18 Alastair Kellock (Glasgow Warriors)
19 John Barclay (Glasgow Warriors)
20 Mike Blair (Edinburgh Rugby)
21 Duncan Weir (Glasgow Warriors)
22 Stuart Hogg (Glasgow Warriors)