Wales coach Warren Gatland has revealed today at the RBS 6 Nations launch that he will be without Gethin Jenkins for the clash against Ireland in Dublin on Sunday week.
Adding to the woe are injuries to key playmaker Rhys Priestland and flanker Dan Lydiate with knee and ankle injuries respectively. Both are rated as 50/50 chances for making the Irish encounter.
"Gethin is struggling and could be out for four to five weeks. Rhys will be struggling for the first game. We're assessing him day by day," said Gatland.
He added: "Dan Lydiate is touch and go. We're hoping Jamie Roberts will be OK".
Gatland admitted the loss of Lions front row Jenkins and Priestland, will be tough acts to follow.
"Gethin is a huge loss for us for potentially the first two games of the tournament. He's been playing exceptionally well for the Blues in the last month.
"He's a world class player. He's got a very good rugby brain and is able to asses things on the field. He's almost like a coach on the field.
"You get a lot of information from him at half-time, what's going right or wrong, tactically where we need to change.
"Rhys was probably the find, if not the best, fly-half at the World Cup. He really does fit the type of game we want to play. His kicking game and vision are excellent. He stretches opposition defences as well because he's not afraid to run.
"There's a very good balance to his game. You can't underestimate the space he created for our midfield at the World Cup.
"He was one of the reasons we saw some really big performances from Jamie Roberts, Jon Davies and Scott Williams. He will be a big loss for us.
"But there's experience to come in with James Hook and we may look at Gavin Henson in that position too."
Meet the members of the WRU's inaugural Youth Board - after an online selection process which saw a host of high calibre candidates submit video applications the WRU has made its first 15 appointments.The board is made up of individuals aged between 16 and 21, and will meet for the first time at Principality Stadium on Monday 15th February.
The Wales Women's team headed to Dare Valley Country Park on a team bonding exercise as the entire squad got together for the very first time in preparation for this season's Six Nations championship which kicks off on Saturday with a clash against defending champions Ireland, in Donnybrook.
Wales Head Coach Warren Gatland discusses his team selection for the opening round of the RBS 6 Nations where he leads his side against Ireland, on Sunday. As WRU TV's Luke Brodley discovers, Gatland is fully aware of the challenges the defending champions pose