Wales coach Warren Gatland has revealed today at the RBS 6 Nations launch that he will be without Gethin Jenkins for the clash against Ireland in Dublin on Sunday week.
Adding to the woe are injuries to key playmaker Rhys Priestland and flanker Dan Lydiate with knee and ankle injuries respectively. Both are rated as 50/50 chances for making the Irish encounter.
"Gethin is struggling and could be out for four to five weeks. Rhys will be struggling for the first game. We're assessing him day by day," said Gatland.
He added: "Dan Lydiate is touch and go. We're hoping Jamie Roberts will be OK".
Gatland admitted the loss of Lions front row Jenkins and Priestland, will be tough acts to follow.
"Gethin is a huge loss for us for potentially the first two games of the tournament. He's been playing exceptionally well for the Blues in the last month.
"He's a world class player. He's got a very good rugby brain and is able to asses things on the field. He's almost like a coach on the field.
"You get a lot of information from him at half-time, what's going right or wrong, tactically where we need to change.
"Rhys was probably the find, if not the best, fly-half at the World Cup. He really does fit the type of game we want to play. His kicking game and vision are excellent. He stretches opposition defences as well because he's not afraid to run.
"There's a very good balance to his game. You can't underestimate the space he created for our midfield at the World Cup.
"He was one of the reasons we saw some really big performances from Jamie Roberts, Jon Davies and Scott Williams. He will be a big loss for us.
"But there's experience to come in with James Hook and we may look at Gavin Henson in that position too."
The WRU has teamed up with Crawshay's to tour Georgia in June. The side, which will be called the Crawshays WRU President's XV, will play Emerging Georgia twice, in a tour which supports the Welsh Government's efforts to grow relations between the two countries.
Wales Sevens are looking to re-group after a disappointing tournament last time out in South Africa. The next double leg in New Zealand and Las Vegas offers Gareth Williams a chance to redeem themselves.
Wales Women's head coach Rhys Edwards was at Llandovery to see the conclusion of an entertaining Women's Regional championship where any one of three teams were in contention for title glory on the last day of action.
Christmas has come early at Glynneath rugby club, one of a number around Wales who have received an array of merchandise and equipment this December courtesy of the Welsh Rugby Union's £750,000 participation points scheme.
The WRU have been delivering on the scheme - which gives individual clubs access to up to £5,000 worth of supplies and equipment each for the 2014/2015 season - over the last two weeks and today (Friday) were received by a special guest in Glynneath, club president and pitch marker Max Boyce.