Wales coach Warren Gatland has revealed today at the RBS 6 Nations launch that he will be without Gethin Jenkins for the clash against Ireland in Dublin on Sunday week.
Adding to the woe are injuries to key playmaker Rhys Priestland and flanker Dan Lydiate with knee and ankle injuries respectively. Both are rated as 50/50 chances for making the Irish encounter.
"Gethin is struggling and could be out for four to five weeks. Rhys will be struggling for the first game. We're assessing him day by day," said Gatland.
He added: "Dan Lydiate is touch and go. We're hoping Jamie Roberts will be OK".
Gatland admitted the loss of Lions front row Jenkins and Priestland, will be tough acts to follow.
"Gethin is a huge loss for us for potentially the first two games of the tournament. He's been playing exceptionally well for the Blues in the last month.
"He's a world class player. He's got a very good rugby brain and is able to asses things on the field. He's almost like a coach on the field.
"You get a lot of information from him at half-time, what's going right or wrong, tactically where we need to change.
"Rhys was probably the find, if not the best, fly-half at the World Cup. He really does fit the type of game we want to play. His kicking game and vision are excellent. He stretches opposition defences as well because he's not afraid to run.
"There's a very good balance to his game. You can't underestimate the space he created for our midfield at the World Cup.
"He was one of the reasons we saw some really big performances from Jamie Roberts, Jon Davies and Scott Williams. He will be a big loss for us.
"But there's experience to come in with James Hook and we may look at Gavin Henson in that position too."
Wales Head Coach Rob Howley talks to WRU TV's Sebastian Barrett about the 36-man squad he has just named for the forthcoming Under Armour series, which includes two uncapped players, Ospreys duo Sam Davies and Rory Thornton.
Head coach Rowland Phillips is deligthed he can now call BT Sport Cardiff Arms Park home for his Wales Women's side, who launch their international season next month with games against Scotland and UK Armed Forces in the heart of the capital city.
Wales Sevens star Sam Cross has put his home town club of Brynmawr on the map after winning a silver medal at the Rio Olympics with Team GB. His club have now honoured him by naming their players bar after him, as WRU TV discovered at the official launch, recently.
One of the newest members of the Principality Premiership, Bargoed admit it's proving to be a steep learning curve at the highest level, but are determined to become a force to be reckoned with. WRU TV visited the club last weekend when they took on Llanelli.
Table-topping Aberavon travel to north Wales to tackle RGC 1404 as both teams defend unbeaten starts to the season in the Principality Premiership. WRU TV's Graeme Gillespie visited the Wizards to see how their preparations were going for the game of the weekend.
The Half a Game initiative is currently sweeping across Wales and proving a major success. The scheme aims to give every young player at least half a game every weekend. WRU TV recently visited a festival in Narberth where clubs have fully embraced the initiative.
Both Bargoed and Swansea were seeking their first win of the Principality Premiership season this afternoon. It proved a fruitful day for the hosts - not only did they win, but Bargoed claimed a try bonus point.