Ashley Smith, Jason Tovey and Tonderai Chavhanga will all miss the trip to France after being forced off during last weekend's win against the Ospreys. Lloyd Burns is also absent again this week after his late withdrawal from last week's squad with illness.
Gavin Thomas does return from his knee injury in time for the Perpignan game and is available for selection. Fly-half Steffan Jones, Scrum -half Jonathan Evans and front rowers Hugh Gustafson and Sam Parry are also called into the squad.
The Dragons comprehensively beat Perpignan 23-13 earlier this season in the home tie at Rodney Parade and will be looking to do the double over their Catalan opponents.
Newport Gwent Dragons Squad
Martyn Thomas, Will Harries, Aled Brew, Tom Riley, Anitelea Tuilagi, Lewis Robling, Matthew Jones, Steffan Jones, Wayne Evans, Jonathan Evans, Toby Faletau, Gavin Thomas, Danny Lydiate (C), Lewis Evans, Tom Brown, Rob Sidoli, Adam Jones, Nathan Buck, Nathan Williams, Dan Way, Phil Price, Rhys Buckley, Steve Jones, Hugh Gustafson, Sam Parry