2009-10 winners Cornish Pirates will welcome fellow RFU Championship side Nottingham Rugby to The Mennaye for an all-English tie in January.
The English quarter finalists are two of only four clubs - along with Leinster A and Ulster - who recorded four straight wins in the pool stages.
The Green & Whites finished Pool 6 a single point behind the Northern Irish men, who will take home advantage in their crunch game against Munster A in the New Year
2011-12 British & Irish Cup Quarter-finals
Cornish Pirates vs. Nottingham Rugby
Ulster vs. Munster A
Leinster A vs. Pontypridd
Cross Keys vs. Llanelli
All matches to be played w/e 20th January