The Ospreys are at full strength and with Lisa Jones (Ryan's sister) returning on the bench alongside the talented youngster Rachel Rees they posses players who can make an impact.
Ospreys coach Ben Rose, said: "The Blues have a strong side out with Lowrie Harries in the front row well known by our girls. The game is sure to be closely contested."
The game is preceded by an Under 15s and Under 18s development day from 10.30am.
The other clash between the Scarlets and Dragons scheduled for Ammanford has been postponed.
Cardiff Blues 15 Rachel Green (Cardiff Quins), 14 Natasha Peters (Pontyclun), 13 Laurie Harries (Cardiff Quins), 12 Phillipa Tuttiett (Cardiff Quins), 11 Cerys Ballett (Cardiff Quins), 10 Joanne Jones (Cardiff Quins), 9 Laura Prosser (Pontyclun), 1 PJ Kinsella (Pontyclun), 2 Lowri Harris (Neath), 3 Nia Sian Jones (Cardiff Quins), 4 Vicky Gaylad (Pontyclun), 5 Anna Brown (Cardiff Quins), 6 Catrina Nicholas (Cardiff Quins), 7 Cat Grundy (Pontyclun) 8 Rebecca Newton (Cardiff Quins)
Replacements: 16 Megan Snape (Gwernyfed), 17 Zoe Wells (Pontyclun), 18 Sam Baker (Cardiff Quins), 19 Beth Kenure (Cardiff Quins), 20 Demi Hallett (Pontyclun), 21 Anna Jenkins (Pontyclun), 22 Brogan Jones (Abercwmboi)
Ospreys: Kerin Lake, Charlie Murray, Adi Taviner, Jami Davies, Courteny Howe, Bethan Preece, Jade Phillips; Shona Powell-Hughes, Jenny Davies, Kath Joseph, Sian Williams, Siwan Lillicrap, Bethan Howell, Amy Lawrence, Jill Richardson.
Replacements: Lucy Jones, Natalie O'Shea, Lisa Jones, Carys Phillips, Natalie Watkins, Rachel Rees, Rosie Fletcher