Joe Bedford is among four players set to make their Dragons debut against Munster.
New signings Tom Brown, Rhys Buckley, Nathan Williams and Joe Bedford are set to make their Dragons RaboDirect PRO12 debuts on Saturday at Musgrave Park as the Men of Gwent take on reigning champions Munster (KO 7:45pm)
Scrum half Wayne Evans has returned from a shoulder injury picked up in the pre-season friendly against Russia to take a place in the squad and Martyn Thomas returns after recovering from the second of two broken legs which have kept him out of league action for several months.
Lewis Evans (calf) and Jamie Smith (back) are being rested for the match.
"Both Lewis and Jamie are ok but we don't want to play anyone who isn't 100% fit," said Dragons Head Coach Darren Edwards.
"There's a great deal of competition in the squad and I'm confident that players who have been given an opportunity this weekend will put in strong performances."
Dragons squad for Munster
Backs Martyn Thomas, Steffan Jones, Adam Hughes, Mike Poole, Pat Leach, Tom Riley, Ashley Smith, Jason Tovey, Wayne Evans, Joe Bedford, Forwards Phil Price, Tom Willis (c), Rhys Buckley, Nathan Williams, Dan Way, Ben Castle, Adam Jones, Jevon Groves, Robert Sidoli, Andrew Coombs, Gavin Thomas, Hugo Ellis, Tom Brown
As the countdown continues for RWC2015, Tournament Chief Executive Debbie Jevans visited the Millennium Stadium to discuss preparations for the eight matches and reveal the positive news that 100,000 tickets for games at the home of Welsh rugby have sold in the last seven days.
Jason Harries is targeting a first win on the World Series circuit this season with Wales. The series returns to action this weekend in Dubai where Harries is part of a team hoping to build from its efforts in round one in October.
Wales skipper Jevon Groves says his side have addressed a few points from Gold Coast and aim to 'hit the ground running' in the next two rounds of the World Series, kicking off with this weekend in Dubai before heading off to South Africa next week.
Wales Sevens manager Steff Thomas is hopeful his side can build from a quarter-final spot in the opening round of the World Series in Australia when his side take part in the forthcoming double header in Dubai and South Africa.