Joe Bedford is among four players set to make their Dragons debut against Munster.
New signings Tom Brown, Rhys Buckley, Nathan Williams and Joe Bedford are set to make their Dragons RaboDirect PRO12 debuts on Saturday at Musgrave Park as the Men of Gwent take on reigning champions Munster (KO 7:45pm)
Scrum half Wayne Evans has returned from a shoulder injury picked up in the pre-season friendly against Russia to take a place in the squad and Martyn Thomas returns after recovering from the second of two broken legs which have kept him out of league action for several months.
Lewis Evans (calf) and Jamie Smith (back) are being rested for the match.
"Both Lewis and Jamie are ok but we don't want to play anyone who isn't 100% fit," said Dragons Head Coach Darren Edwards.
"There's a great deal of competition in the squad and I'm confident that players who have been given an opportunity this weekend will put in strong performances."
Dragons squad for Munster
Backs Martyn Thomas, Steffan Jones, Adam Hughes, Mike Poole, Pat Leach, Tom Riley, Ashley Smith, Jason Tovey, Wayne Evans, Joe Bedford, Forwards Phil Price, Tom Willis (c), Rhys Buckley, Nathan Williams, Dan Way, Ben Castle, Adam Jones, Jevon Groves, Robert Sidoli, Andrew Coombs, Gavin Thomas, Hugo Ellis, Tom Brown
Nearly 40 players were involved in the first Wales Under 18 training session of the season. WRU National Performance Manager Gethin Watts is excited at the potential shown by the group and expects the Regional Under 18 Championship to hone their skills even further.