Lewis Evans (calf) and Jamie Smith (back) are being rested for the match.
"Both Lewis and Jamie are ok but we don't want to play anyone who isn't 100% fit," said Dragons Head Coach Darren Edwards.
"There's a great deal of competition in the squad and I'm confident that players who have been given an opportunity this weekend will put in strong performances."
Dragons squad for Munster
Backs Martyn Thomas, Steffan Jones, Adam Hughes, Mike Poole, Pat Leach, Tom Riley, Ashley Smith, Jason Tovey, Wayne Evans, Joe Bedford,
Forwards Phil Price, Tom Willis (c), Rhys Buckley, Nathan Williams, Dan Way, Ben Castle, Adam Jones, Jevon Groves, Robert Sidoli, Andrew Coombs, Gavin Thomas, Hugo Ellis, Tom Brown