Andrew Hall will play in the second row for Adam Jones, due to illness, and Richard Parks returns from injury with Michael Owen moving to the replacements bench.
Head Coach Paul Turner said, "We assessed the squad after last weekend and the changes made are due to both combination and form.
"It's good to have Richard Parks back after injury. The players are well aware of the need to put in a huge performance at the Liberty Stadium on Friday."
Dragons: Kevin Morgan; Gareth Wyatt, Paul Emerick, Rhodri Gomer Davies, Richard Mustoe; Ceri Sweeney, Andy Williams; Adam Black, Ben Daly, Rhys Thomas, Andrew Hall, Luke Chateris, Colin Charvis (captain), Richard Parks, Joe Bearman
Replacements: Steve Jones, Lee Harrison, Michael Owen, Lewis Evans, Aled Thomas/Jason Tovey, Phillip Dollman, Wayne Evans