Unbeaten Two East side Llantrisant should have too much for Abercrave in Round One of the SWALEC Cup when the sides meet at Cefn Mably on Saturday.
The Black Army are four points clear at the top of their division but their visitors from Five South East will also be defending an unbeaten record after three straight league wins.
Rhymney of Three East travel to Rhydyfelin of Two East with the Brewers still looking for their first victory of the season. Rhydyfelin have six points from their opening three matches and will give their visitors a severe test.
St Peter's will always be able to look back on their epic 16-14 cup victory over Cardiff in the 1992-93 season but visitors Ammanford, who have made a flying start in Two West, could well deliver a knock-out blow to the Rocks at the first time of asking.
Abertillery BG are on course for a return to former glories after two league promotions. Now playing in Three East, they travel along the Heads of the Valleys road to Five South East's Hirwaun hoping to make cup progress.
Two West's Gorseinon have lost both opening league matches and will not be relishing a visit from Llandaff to the Welfare Ground. The side from Bishop's Field in Cardiff top Four East having won both their league encounters.
Welsh Districts outfits Aberystwyth University and UWIN have home ties against Bethesda of Two North and Caldicot of Five East, while Cardiff Medicals have a tough tie away to Bridgend Athletic of Two West.
Brecon have received a walkover as North Wales side Bangor are unable to raise a side for the long trip down to the Beacons.
Abercynon v Taibach
Aberystwyth University v Bethesda
Bettws (Newport) v Blaina
Blaengarw v Caernarfon
Brecon v Bangor (w/o Brecon)
Bridgend Athletic v Cardiff Medicals
Cilfynydd v Cardigan
Colwyn Bay v Laugharne
Cwmavon v Pontardawe
Cwmtwrch v Pontycymmer
Dinas Powys v Tenby
Dowlais v Bridgend Sports
Fleur de Lys v Cardiff HSOB
Furnace v Taffs Well
Glyncorrwg v Crymych
Gorseinon v Llandaff
Hirwaun v Abertillery BG
Llandeilo v Welshpool
Llantrisant v Abercrave
Llanybydder v Pembroke Dock Quins
Machen v Newcastle Emlyn
Morriston v Ynysybwl
Mountain Ash v Skewen
Neath Athletic v Pwllheli
Newtown v Gowerton
New Tredegar v Dolgellau
Neyland v Bedlinog
Pembroke v South Wales Police
Penarth v Baglan
Pentyrch v Loughor
Penygraig v Talywain
Pontarddulais v Senghenydd
Pontypool United v Tredegar Ironsides
Pyle v Rhiwbina
Rhydyfelin v Rhymney
Rhyl v Nantyffyllon
Seven Sisters v Tonyrefail
St Peters v Ammanford
Tonna v Llantwit Major
Trebanos v Monmouth
Tredegar v Pontllanfraith
Treorchy v St Clears
Trinant v Nantyglo
Tylorstown v Denbigh
UWIN v Caldicot
Wrexham v Deri
Wales Head Coach Rob Howley talks to WRU TV's Sebastian Barrett about the 36-man squad he has just named for the forthcoming Under Armour series, which includes two uncapped players, Ospreys duo Sam Davies and Rory Thornton.
Head coach Rowland Phillips is deligthed he can now call BT Sport Cardiff Arms Park home for his Wales Women's side, who launch their international season next month with games against Scotland and UK Armed Forces in the heart of the capital city.
Wales Sevens star Sam Cross has put his home town club of Brynmawr on the map after winning a silver medal at the Rio Olympics with Team GB. His club have now honoured him by naming their players bar after him, as WRU TV discovered at the official launch, recently.
One of the newest members of the Principality Premiership, Bargoed admit it's proving to be a steep learning curve at the highest level, but are determined to become a force to be reckoned with. WRU TV visited the club last weekend when they took on Llanelli.
Table-topping Aberavon travel to north Wales to tackle RGC 1404 as both teams defend unbeaten starts to the season in the Principality Premiership. WRU TV's Graeme Gillespie visited the Wizards to see how their preparations were going for the game of the weekend.
The Half a Game initiative is currently sweeping across Wales and proving a major success. The scheme aims to give every young player at least half a game every weekend. WRU TV recently visited a festival in Narberth where clubs have fully embraced the initiative.
Both Bargoed and Swansea were seeking their first win of the Principality Premiership season this afternoon. It proved a fruitful day for the hosts - not only did they win, but Bargoed claimed a try bonus point.
Cardiff managed to keep their unbeaten record at home intact, but only just as Bridgend made them work extremely hard before the Blue and Blacks secured a hard fought Principality Premiership win at the BT Sport Arms Park last night.
Former Wales back row Andy Powell gives a guided tour of The Wern, home of Merthyr RFC, who are determined to prove a lot of people wrong and make their mark in their first season in the Principality Premiership.