Xavier Rush has been named on the Cardiff Blues bench for the clash with Connacht.
Talismanic number eight Rush suffered a shoulder injury in pre-season and was expected to be out until at least next month.
And while Rush is back ahead of schedule, there is also returns from injury for Richie Rees and Deiniol Jones.
The Blues have made a stuttering start in the Magners League but coach Dai Young insists they are determined to bounce back from last week's 28-20 defeat at Munster.
Young said: "That was probably the best we've played all season. If we play like that week-in, week-out we'll win a lot more than we lose.
"All we can do now is build on the performance at Musgrave Park for the visit of Connacht to the Arms Park."
Wales prop Gethin Jenkins misses out with a neck injury and joins Tom James, Martyn Williams, Rhys Williams and Sam Warburton on the sidelines.
The Blues will defend an unbeaten record at the Arms Park which stretches back to January while Connacht have not won in Cardiff since 2001.
Blues: Leigh Halfpenny; Richard Mustoe, Jamie Robinson, Jamie Roberts, Gareth Thomas; Ceri Sweeney, Jason Spice; John Yapp, T Rhys Thomas, Gary Powell, Deiniol Jones, Paul Tito (capt), Maama Molitika, Andy Powell, Robin Sowden-Taylor.
Replacements: Taufa'ao Filise, Rhys Williams, Scott Morgan, Xavier Rush, Richie Rees, Nicky Robinson, Tom Shanklin.
Connacht: F Carr; A Wynne, J Hearty, M Deane, M Roberts; A Dunne, F Murphy; J Lyne, A Flavin, R Morris; A Browne, M Swift; J Muldoon (C), J O'Connor, C Rigney.
Replacements: S Cronin, R Loughney, A Farley, M McCarthy, K Campbell, I Keatley, L Bibo.
The WRU has teamed up with Crawshay's to tour Georgia in June. The side, which will be called the Crawshays WRU President's XV, will play Emerging Georgia twice, in a tour which supports the Welsh Government's efforts to grow relations between the two countries.
Wales Sevens are looking to re-group after a disappointing tournament last time out in South Africa. The next double leg in New Zealand and Las Vegas offers Gareth Williams a chance to redeem themselves.
Wales Women's head coach Rhys Edwards was at Llandovery to see the conclusion of an entertaining Women's Regional championship where any one of three teams were in contention for title glory on the last day of action.