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"There's no doubt that it's been a difficult week with three matches in just seven days but it provides a true test of our squad depth," said Holley, who saw his side win away in Connacht on the day of the new season before defeating the Blues 32-10 at the Liberty Stadium.
"There are a lot of familiar faces in the team with a good splash of youth. This is a real indication of the good work we are doing to develop the best local young talent.
Glasgow have themselves started well, returning from Rodney Parade with a 12-6 win over the Dragons.
"We've had a solid start in the Magners League but we're expecting a real test.
"Glasgow played some exciting rugby last season and have started well this time around with a win at Rodney Parade against the Dragons last weekend.
"We are well aware that we'll have to be at our best to get a result."
New signing Jamie Nutbrown and 18-year-old Dan Biggar make their first competitive starts for the Ospreys at half-back while David Bishop plays for the first time in more than three years after suffering a fractured kneecap.
Ospreys (vs Glasgow, kick-off 7.30pm)
15 Gareth Owen
14 Johnny Vaughton
13 David Bishop
12 Andrew Bishop
11 Nikki Walker
10 Daniel Biggar
9 Jamie Nutbrown
8 Filo Tiatia
7 Marty Holah
6 Tom Smith
5 Alun Wyn Jones
4 Ian Gough
3 Cai Griffiths
2 Ed Shervington
1 Paul James (capt)
Replacements
16 Huw Bennett
17 Duncan Jones
18 Andy Lloyd
19 Jonathan Thomas
20 Rhys Webb
21 James Hook
22 Kristian Phillips
