There is a top of the table clash at Bargoed in One East where the home side entertain the Ironmen of Merthyr. Both sides have ten points but Merthyr have played one more game
. Two other unbeaten sides meet at Glan yr Afon Park where Blackwood entertain a Newbridge outfit that crossed for three tries in their last outing at Beddau.
It's top against bottom in One West with leaders Carmarthen Quins travelling to Dunvant.The Broadacre side are without a single point after their opening three matches while Quins have run in 11 tries for three straight victories. Corus are also without a point but they travel to a Carmarthen Athletic side that were hammered 78-7 last weekend and will be confident of getting something from the game.
The first round of the SWALEC Cup leaves Two East with just one fixture at Treherbert. The home side are bottom of the table with two defeats but visitors Abergavenny have lost all three of their league matches. It should be a tight game at Tynewydd Park. Builth Wells are enjoying life in Two West and could go top of the table but their trip to Kidwelly will provide them with a severe test as the home side already boast a couple of victories. The only other game in this division is at Penclawdd where the Cocklemen face Waunarlwydd.
Gwernyfed will be looking to consolidate their top placing in Three East when they entertain Nelson but the visitors are unbeaten to date and could take over first spot themselves with an away victory. Cwmbran make the short trip to Pill Harriers in the only other match in this division.
Llandaff North are still looking for their first victory in Three South East. The visit of bottom club Aberdare will give them an opportunity of registering their first success.
There are three fixtures in Three West with top side Pontyberem hosting Haverfordwest, Lampeter travelling to Tumble, and a bottom of the table clash at Cwmamman Park where Amman United meet Llanelli Wanderers.
Tondu could go top of Three South West if they overcome Briton Ferry while Aberavon Quins have a visit from Kenfig Hill.
St Joseph's and Brynithel meet in Cardiff for only their second Four East league match of the season with neither side having registering a victory.
Hendy and Brynamman meet in Four West with the winners aiming for top of the table. Tycroes may just spoil that possibility with victory at Betws. Burry Port meet Trimsaran in the last of the matches in this division.
Abercarn will be hoping to maintain their Five East unbeaten record when they travel to Usk, while Oakdale go to Llanhilleth looking for a third victory in a row, Cefneithen go to Swansea Uplands in Five West with the home side looking for their first points of the season.
The last five years have been an emotional rollercoaster on and off the pitch for RGC1404. Promotion to the Principality Premiership was the culmination of five years of hard work and investment in North Wales. WRU TV caught up with prop Joe Simpson, who was one of the first intake of WRU North Wales Academy players in 2010.
Ebbw Vale captain Damien Hudd picked up the biggest accolade of the night at the 11th Principality Premiership Awards Evening held at Principality Stadium, after leading his side to the title for the first time.
Wales assistant coach Robin McBryde is predicting a tough battle against England on Sunday despite the fact they may not be considered to be at full strength. Players will be out to impress Eddie Jones which makes England a dangerous proposition, he says.
Wales U20 captain Tom Phillips and performance psychologist Dr Rich Neil explain why spending three days at Monmouth RFC has further strengthened the togetherness of the squad ahead of the #WorldRugbyU20s