There is a top of the table clash at Bargoed in One East where the home side entertain the Ironmen of Merthyr. Both sides have ten points but Merthyr have played one more game
. Two other unbeaten sides meet at Glan yr Afon Park where Blackwood entertain a Newbridge outfit that crossed for three tries in their last outing at Beddau.
It's top against bottom in One West with leaders Carmarthen Quins travelling to Dunvant.The Broadacre side are without a single point after their opening three matches while Quins have run in 11 tries for three straight victories. Corus are also without a point but they travel to a Carmarthen Athletic side that were hammered 78-7 last weekend and will be confident of getting something from the game.
The first round of the SWALEC Cup leaves Two East with just one fixture at Treherbert. The home side are bottom of the table with two defeats but visitors Abergavenny have lost all three of their league matches. It should be a tight game at Tynewydd Park. Builth Wells are enjoying life in Two West and could go top of the table but their trip to Kidwelly will provide them with a severe test as the home side already boast a couple of victories. The only other game in this division is at Penclawdd where the Cocklemen face Waunarlwydd.
Gwernyfed will be looking to consolidate their top placing in Three East when they entertain Nelson but the visitors are unbeaten to date and could take over first spot themselves with an away victory. Cwmbran make the short trip to Pill Harriers in the only other match in this division.
Llandaff North are still looking for their first victory in Three South East. The visit of bottom club Aberdare will give them an opportunity of registering their first success.
There are three fixtures in Three West with top side Pontyberem hosting Haverfordwest, Lampeter travelling to Tumble, and a bottom of the table clash at Cwmamman Park where Amman United meet Llanelli Wanderers.
Tondu could go top of Three South West if they overcome Briton Ferry while Aberavon Quins have a visit from Kenfig Hill.
St Joseph's and Brynithel meet in Cardiff for only their second Four East league match of the season with neither side having registering a victory.
Hendy and Brynamman meet in Four West with the winners aiming for top of the table. Tycroes may just spoil that possibility with victory at Betws. Burry Port meet Trimsaran in the last of the matches in this division.
Abercarn will be hoping to maintain their Five East unbeaten record when they travel to Usk, while Oakdale go to Llanhilleth looking for a third victory in a row, Cefneithen go to Swansea Uplands in Five West with the home side looking for their first points of the season.
Sam Cross and Luke Treharne have been named as co-captains of the Wales Sevens side as head coach Gareth Williams names his 12-man squad to play in the first leg of the HSBC World Series in Dubai next weekend.
Bedwas head coach Steve Law and players Nicky Griffiths and Alun Rees extol the virtues of the close knit club as they prepare to host third place RGC 1404 - who are one place head of them on the Principality Premiership points table - on Saturday.
Many of the Wales squad have said Diolch (thank you) to someone who played an important part in their early playing days by nominating them to be invited to the Wales v South Africa match. One person, Gowerton Comprehensive geography teacher Mr Dean Mason was nominated by two of his former pupils, Dan Biggar and Sam Davies.
The second WRU disability rugby pilot has been delivered, this time in Caerphilly schools, culminating in a festival at the Caerphilly Centre of Sporting Excellence, Ystrad Mynach tomorrow. Plans are in place to set up a Disability Rugby Club in Newbridge to provide long-term playing opportunities.
WRU TV: Hear from inside the Wales camp as Neil Jenkins discusses this weekend's clash with South Africa and how the squad are looking to put in a strong performance to round of the 2016 Under Armour Series