Among the returnees, the Welsh All Blacks welcome back Wayne Mitchell, Bryan Shelbourne, Gareth James, Martin Jones and Neil Edwards who all missed the win over Cross Keys.
Director of Rugby Rowland Phillips said. "Bedwas is never an easy place to go and their loss at Swansea last time out was probably not a good thing from our point of view.
"They are always a stiff challenge but it is a challenge we are looking forward to. They have some swift backs and their forwards will contest every ball so we'll need to match them at every phase.
"As for Neath, we can take heart from last week's 62-20 win over Cross Keys. To score 9 tries against any side in the Premiership is no mean feat and one from which we will draw confidence.
"But nobody is getting carried away at The Gnoll because that is not our way and the reality is that, taken as a whole, the game was much closer than the score suggested.
"We are putting into place some new systems this season because we cannot stand still. The squad is working hard to adjust and the latter part of last week's game was very encouraging. Our aim is to continue to improve game by game."
Neath squad: G.King, L.Powell, M.Nuthall, K.James, D.Evans, D.Lockyer, W.Mitchell, M.Jarvis, G.James, T.Knoyle, B.Shelbourne, M.Jones, N.Downs, C.Mitchell, A.N.Other, G.Price, A.Littlehales, J.Richards, E.Evans, N.Edwards, H.Pugh, C.Ruddock, L.Evans, A.Llewellyn, J.Bowd, L.Beach (captain), G.Gravell