The Llynfi Road side were relegated last season and will be looking to bounce straight back to the top flight. Tonmawr, who were champions of One West last season, should provide the biggest challenge to Maesteg alongside Carmarthen Quins.
Tonmawr begin at Whitland while Quins play host to Llangennech.
In One East, Penallta's rapid rise up the divisions will be tested by visitors Blackwood, while last season's runners-up, Caerphilly, will be hoping to go one better this year. The Cheesemen entertain a Newbridge side that promised much in the early part of last season before falling away to mid-table.
In Two East, Mountain Ash will be making a big effort to improve on their third place last season. They travel to Treherbert where they were pipped 11-10 last season.
In Two West, Loughor, Mumbles and Pencoed hope last season's good form will continue as they take on Gorseinon, relegated Waunarlwydd, and Builth Wells respectively. The mid-Wales club have been switched this season from East to West and the change may well suit the Powys club.
Three East will be very much a Gwent affair with a number of derby matches to look forward to. Garndiffaith and Croesyceiliog could set the early running with Garn opening at Nelson while the Cockerels visit Rhymney.
Five clubs from Cardiff will do battle in Three South East with Llanishen entertaining Fairwater on Saturday in a real derby encounter. Newly-promoted Llandaff North travel to the seaside to take on Penarth, Old Illtydians visit Llantwit Fardre and Abverdare play host to St Peter's.
Four West will see a renewal of the Pembrokeshire rivalry with the relegated Pembroke Dock Quins resuming league matches against Pembroke. Their first meeting could come as early as September 27. Quins open their programme away to Burry Port while Pembroke entertain Tenby.
This season, Four North and Five North have been renamed One North and Two North. Four North champions Caernarfon open up at Pwllheli who were champions of Five North last term.
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Newsroom
SWALEC League launches
4 September 2008 14:13pm
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The SWALEC Leagues begin on Saturday with former Premier side Maesteg entertaining Corus (Port Talbot) in Division One West.
WRU TV
30 Jan 15
Despite facing a daunting task in New Zealand for the fourth round of the HSBC Sevens World Series, Wales Sevens head coach Gareth Williams is heading Down Under in a positive frame of mind.
29 Jan 15
WRU TV were on site at the RBS 6 Nations launch in London on Wednesday and caught up with all the action
29 Jan 15
Wales Women's captain Rachel Taylor and England opposite number Tamara Taylor look ahead to the opening game of this season's campaign.
28 Jan 15
Wales head coach Warren Gatland talks about the rapidly approaching RBS 6 Nations campaign at today's launch in London.
27 Jan 15
Meet Wales U20s: WRUTV caught up with Josh Adams in this video special
27 Jan 15
Meet Wales U20s: Joe Davies, powerful forward and son of a Wales Commonwealth Games gold medallist.
27 Jan 15
WRU TV went behind the scenes as the Wales squad met for the first time ahead of the RBS 6 Nations, following them through a day of training, meetings, headshot and media.
21 Jan 15
The WRU has teamed up with Crawshay's to tour Georgia in June. The side, which will be called the Crawshays WRU President's XV, will play Emerging Georgia twice, in a tour which supports the Welsh Government's efforts to grow relations between the two countries.
21 Jan 15
Wales Sevens are looking to re-group after a disappointing tournament last time out in South Africa. The next double leg in New Zealand and Las Vegas offers Gareth Williams a chance to redeem themselves.
20 Jan 15
Warren Gatland spoke to the media after announcing his 34-man 2015 RBS 6 Nations squad
20 Jan 15
Penallta eased through to the next round of the SSE SWALEC Plate with a convincing 46-5 victory over Heol y Cyw. WRU TV was there to capture the action.
19 Jan 15
Video of the Womens Leagues and Regional Awards Evening.
16 Jan 15
A number of innovative changes to scoring have been introduced at age grade regional level in an attempt to ensure try-scoring is the main focus
15 Jan 15
WRU TV went to Sardis Road as underdogs Bargoed attempted to cause a shock upset over SWALEC Cup holders Pontypridd.
15 Jan 15
Chris Horsman, Geraint Lewis and Jason Strange have got stuck into their work as international skills coaches, affecting how young people play the game right across the board.
15 Jan 15
Having selected his Six Nations squad, Wales Women's head coach Rhys Edwards is now focusing on the opening game of the campaign against England.
12 Jan 15
Seventy-four riders completed a sponsored bike ride from Cardiff to Aberdare to support the fundraising campaign #staystrongforows following Owen Williams' serious rugby injury last summer.
12 Jan 15
Wales Women's head coach Rhys Edwards was at Llandovery to see the conclusion of an entertaining Women's Regional championship where any one of three teams were in contention for title glory on the last day of action.
08 Jan 15
WRU National Performance Manager Gethin Watts outlines a new coaching system as the final countdown rapidly approaches for a new Six Nations campaign for Wales Under 20s.
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