The Llynfi Road side were relegated last season and will be looking to bounce straight back to the top flight. Tonmawr, who were champions of One West last season, should provide the biggest challenge to Maesteg alongside Carmarthen Quins.
Tonmawr begin at Whitland while Quins play host to Llangennech.
In One East, Penallta's rapid rise up the divisions will be tested by visitors Blackwood, while last season's runners-up, Caerphilly, will be hoping to go one better this year. The Cheesemen entertain a Newbridge side that promised much in the early part of last season before falling away to mid-table.
In Two East, Mountain Ash will be making a big effort to improve on their third place last season. They travel to Treherbert where they were pipped 11-10 last season.
In Two West, Loughor, Mumbles and Pencoed hope last season's good form will continue as they take on Gorseinon, relegated Waunarlwydd, and Builth Wells respectively. The mid-Wales club have been switched this season from East to West and the change may well suit the Powys club.
Three East will be very much a Gwent affair with a number of derby matches to look forward to. Garndiffaith and Croesyceiliog could set the early running with Garn opening at Nelson while the Cockerels visit Rhymney.
Five clubs from Cardiff will do battle in Three South East with Llanishen entertaining Fairwater on Saturday in a real derby encounter. Newly-promoted Llandaff North travel to the seaside to take on Penarth, Old Illtydians visit Llantwit Fardre and Abverdare play host to St Peter's.
Four West will see a renewal of the Pembrokeshire rivalry with the relegated Pembroke Dock Quins resuming league matches against Pembroke. Their first meeting could come as early as September 27. Quins open their programme away to Burry Port while Pembroke entertain Tenby.
This season, Four North and Five North have been renamed One North and Two North. Four North champions Caernarfon open up at Pwllheli who were champions of Five North last term.
Newsroom
SWALEC League launches
4 September 2008 14:13
By
The SWALEC Leagues begin on Saturday with former Premier side Maesteg entertaining Corus (Port Talbot) in Division One West.
WRU TV
13 Apr 18
As both Cardiff Blues and Ospreys target automatic qualification for next year's EPCR Champions Cup, the significance of their already much anticipated Judgement Day VI clash later this month is growing exponentially.
WRU
13 Apr 18
Brynmawr, with former Ebbw Vale stalwart Damien Hudd at the helm, fought their way to the WRU Plate final after a titanic struggle with Nelson at Llanharan
WRU
10 Apr 18
Players and fans alike were jumping for joy at the final whistle when Porthcawl edged out Abercwmboi in the WRU semi-final held at Taffs Well, to earn a spot in the final to be held at Principality Stadium.
WRU
08 Apr 18
Cardiff Arms Park was the venue for the second round of the U18 Six Nations festival where there was plenty of action and thrills and spills.
Roland Mercer
27 Mar 18
Justin Tipuric and Hallam Amos are looking forward to their return to sevens after being named for Team Wales' assignment in the Commonwealth Games where they will be chasing a gold medal.
Roland Mercer
26 Mar 18
Wales Sevens stalwart Adam Thomas is delighted to be handed the captaincy as Team Wales prepare to chase medal glory in the Commonwealth Games
Roland Mercer
17 Mar 18
Second row Cory Hill is a relieved man after Wales secured a gritty 14-13 victory against France at Principality Stadium in the final round of the NatWest 6 Nations
16 Mar 18
Having signed a national dual contract earlier in the week, Wales captain Alun Wyn Jones will be hoping for a double celebration by leading his country to second place in the NatWest 6 Nations when coming up against France in the final round.
16 Mar 18
Captain PhilipaTuttiett and Olympic Games star Jasmine Joyce discuss next month's Commonwealth Games along with coach Nick Wakley
16 Mar 18
Tomas Francis gets the rare chance of successive starts for Wales when they tackle France in the final round of the NatWest 6 Nations at Principality Stadium
13 Mar 18
We take a look back to round four of the NatWest 6 Nations where Wales hosted Italy at Principality Stadium
13 Mar 18
Watch highlights from round four of the NatWest 6 Nations where Wales marched to second in the points table after a comfortable victory against Italy.
12 Mar 18
WRU TV takes a look back to the first game of the double-header staged at Principality Stadium where Italy Women proved party poopers for Wales in the fourth round of the Women's Six Nations.
11 Mar 18
George North inched closer to Shane Williams record of 22 tries in the Six Nations, his brace taking him to third on the list with Gareth Edwards (18) now in his sights. He looks back on a job well done by Wales.
10 Mar 18
Taulupe Faletau is looking forward to his first game as Wales captain where he will play alongside debutant James Davies in a fresh looking back row against Italy in the NatWest 6 Nations tomorrow afternoon in Cardiff
08 Mar 18
No 8 Ross Moriarty recalls his memories of when he played in the Six Nations championship for the first time, when he came on as a replacement against Italy and scored two tries.
07 Mar 18
Head coach Warren Gatland has handed 'world-class' Taulupe Faletau the captaincy for Wales' clash against Italy on Sunday, and believes it is an opportunity for Wales to get even 'more out of him in terms of leadership qualities'
07 Mar 18
Scarlets and Wales centre Jonathan Davies visited Llandough School last week to meet a pupil who had won a poetry competition to surprise her mam with Wales v Italy tickets.
06 Mar 18
The Wales squad reported back into camp this morning ahead of Sunday's vital NatWest 6 Nations encounter against Italy. Assistant coach Neil Jenkins says the return of Taulupe Faletau is a big plus for the team.
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