The Llynfi Road side were relegated last season and will be looking to bounce straight back to the top flight. Tonmawr, who were champions of One West last season, should provide the biggest challenge to Maesteg alongside Carmarthen Quins.
Tonmawr begin at Whitland while Quins play host to Llangennech.
In One East, Penallta's rapid rise up the divisions will be tested by visitors Blackwood, while last season's runners-up, Caerphilly, will be hoping to go one better this year. The Cheesemen entertain a Newbridge side that promised much in the early part of last season before falling away to mid-table.
In Two East, Mountain Ash will be making a big effort to improve on their third place last season. They travel to Treherbert where they were pipped 11-10 last season.
In Two West, Loughor, Mumbles and Pencoed hope last season's good form will continue as they take on Gorseinon, relegated Waunarlwydd, and Builth Wells respectively. The mid-Wales club have been switched this season from East to West and the change may well suit the Powys club.
Three East will be very much a Gwent affair with a number of derby matches to look forward to. Garndiffaith and Croesyceiliog could set the early running with Garn opening at Nelson while the Cockerels visit Rhymney.
Five clubs from Cardiff will do battle in Three South East with Llanishen entertaining Fairwater on Saturday in a real derby encounter. Newly-promoted Llandaff North travel to the seaside to take on Penarth, Old Illtydians visit Llantwit Fardre and Abverdare play host to St Peter's.
Four West will see a renewal of the Pembrokeshire rivalry with the relegated Pembroke Dock Quins resuming league matches against Pembroke. Their first meeting could come as early as September 27. Quins open their programme away to Burry Port while Pembroke entertain Tenby.
This season, Four North and Five North have been renamed One North and Two North. Four North champions Caernarfon open up at Pwllheli who were champions of Five North last term.
Newsroom
SWALEC League launches
4 September 2008 14:13pm
By
The SWALEC Leagues begin on Saturday with former Premier side Maesteg entertaining Corus (Port Talbot) in Division One West.
WRU TV
19 Apr 14
Millennium Stadium manager Mark Williams is excitedly looking forward to tomorrow's Judgement Day II where all four regions will be playing at the Cardiff cathedral of rugby.
17 Apr 14
The Millennium Stadium will host the biggest beer festival in Wales when the inaugural 'W-Ales Beer Festival' comes to the iconic city-centre venue this summer (5-7 June).
17 Apr 14
Porthcawl recently received a WRU facilities grant and funding from Natwest RugbyForce in order to give their changing rooms a facelift. This came after receiving £10,000 in a WRU facilities grant last year to tarmac their car park. The improvements have already helped to make the club more accessible, not only for their own members and players but for the whole community.
16 Apr 14
The Welsh Rugby Union has launched a new, accredited Safeguarding and Protecting Children course - funded by the WRU and delivered in partnership with Sport Wales and the NSPCC - fo rugby club volunteers around Wales.
16 Apr 14
Sunday's 'Judgement Day II' at the Millennium Stadium is rapidly approaching - yesterday all four regions assembled at Cardiff Castle to promote the regional double header.
07 Apr 14
WRU Compliance Manager Will Thomas explains the initiative to identify and develop future administrators who want to forge a career in the rugby industry.
03 Apr 14
Highlights of the Welsh Schools Under 18 Final which Llanishen High won, beating Ysgol y Preseli 19-17.
02 Apr 14
The Millennium Stadium is set for another double-derby extravaganza on Easter Sunday 2014 with the Cardiff Blues taking on the Scarlets at 2pm and Newport Gwent Dragons facing the Ospreys at 4.45pm.
30 Mar 14
Wales Head Coach Gareth Williams is full of praise for his side who pushed South Africa all the way before just falling short in the Plate final at the Hong Kong Sevens.
27 Mar 14
The SWALEC semi-final draws threw up some mouth-watering clashes in the Cup, Plate and Bowl as the 12 teams aim for the Millennium Stadium Finals Day. All the semi-finals are to be played on the weekend of April 12.
27 Mar 14
Welsh whistler Rhys Thomas continues to scale the heights of the game as he prepares to be an official in this weekend's Hong Kong Sevens tournament, undoubtedly the showpiece event on the World Series calendar.
26 Mar 14
Wales Sevens manager Dai Jenkins is in a positive mood as his side prepare to tackle Fiji in a crucial showdown on Friday night in the Hong Kong Sevens, as WRU TV's Graeme Gillespie discovers
26 Mar 14
Wales International Ian Evans and Wales and Lions legend Scott Quinnell swapped rugby balls for paint pots at Tonna during the RBS 6 Nations. They surprised club players with a special clubhouse makeover to launch NatWest RugbyForce 2014 - a programme developed in partnership with the WRU to make rugby clubs stronger businesses by improving and renovating their facilities with the support of volunteers and the local community.
26 Mar 14
Rhiwbina joined Glynneath, Llantwit Fadre and Merthyr in the semi-finals of the Swalec Plate with a 36-19 win over Nant Conwy. Here's how they reached the final four.
25 Mar 14
Pontypridd remain on course to retain their Swalec Cup crown after they eased past Llanelli to reach the semi-finals. Here's how the holders hit their visitors for a half century at Sardis Road.
25 Mar 14
We're now down to the final few in the Swalec Bowl: here's a look back at how Llantwit Major saw off Pyle in the quarter-finals on Saturday.
25 Mar 14
Fresh from claiming the Bowl honours in Tokyo last Sunday, the Wales Sevens squad have settled into their routine as they prepare for this weekend's Hong Kong tournament where Iolo Evans is aiming high, as WRU TV's Graeme Gillespie discovers.
24 Mar 14
In perfect playing conditions Wales U18s were beaten six tries to two by a very good English side at the Gnoll.
21 Mar 14
Wales Under 18 face England in Neath this Sunday. WRU TV previews the game with some of the squad's key men.
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