Cardiff Blues coach Dai Young has rung the changes for his side's trip to the Liberty Stadium to face the Ospreys on Tuesday night (kick-off 7.35pm).
Having drawn 16-16 with the Magners League champions Leinster on the opening day of the season, the Blues now find themselves facing the EDF Energy Cup holders three days later.
And with Ulster coming to the Arms park on Friday night, making it three games in seven days, Young has stood down a number of first-choice players for the away trip.
"The Blues v Ospreys is obviously a big game in Wales, so it's a pity it's shoved in the middle of the week. We've only really had one day preparation for it which isn't ideal," explained Young.
"We've had to juggle teams because when you go from a Saturday game to a Tuesday match, the preparation is practically non existent.
"They have the same coaches who were there last year with Lyn, so we're expecting very much more of the same. Maybe they will make little changes here and there, but we know enough about their players and they know enough about us."
"I think both teams have a lot of skilful players, so I have no doubt that it will be a quality game. The Liberty Stadium is a great stadium to play at and I think the Ospreys are going to be up there at the end of the season.
"I know its going to be a big test for us."
There are nine new faces among the starting XV from the side that faced Leinster, with seven players, including new club skipper Paul Tito, reverting to bench duty. Welsh international Robin Sowden-Taylor returns to action for the first time since damaging his shoulder in March.
Cardiff Blues: Ben Blair; Richard Mustoe, Jamie Robinson, Jamie Roberts, Aled Brew; Ceri Sweeney, Darren Allinson; Taufa'ao Filise, T. Rhys Thomas, Gary Powell, Bradley Davies, Scott Morgan, Ben White, Robin Sowden-Taylor, Andy Powell.
Relacements: Gethin Jenkins, Gareth Williams, Paul Tito, Ma'ama Molitika, Jason Spice, Nicky Robinson, Tom Shanklin
Wales and Ospreys back row James King, who came through the North Wales age grade system, nominated North Wales Regional Community Rugby Manager Marc Roberts, in the WRU's 'Diolch' initiative where squad players thanked those who played a part in their rise to the top.
Beating Merthyr has boosted Carmarthen Quins hopes of reaching a top eight spot in the Principality Premiership. Quins captain Haydn Pugh is delighted with his team's progress and is determined that everyone from the Under 6s through to the senior team, enjoys the ride.
When the Wales squad were asked to nominate individuals who played a big part in their early playing days, Wales and Dragons full back and wing Hallam Amos thought of his former Monmouth School rugby coach John Bevan.
Sam Cross and Luke Treharne have been named as co-captains of the Wales Sevens side as head coach Gareth Williams names his 12-man squad to play in the first leg of the HSBC World Series in Dubai next weekend.
Bedwas head coach Steve Law and players Nicky Griffiths and Alun Rees extol the virtues of the close knit club as they prepare to host third place RGC 1404 - who are one place head of them on the Principality Premiership points table - on Saturday.
Many of the Wales squad have said Diolch (thank you) to someone who played an important part in their early playing days by nominating them to be invited to the Wales v South Africa match. One person, Gowerton Comprehensive geography teacher Mr Dean Mason was nominated by two of his former pupils, Dan Biggar and Sam Davies.
The second WRU disability rugby pilot has been delivered, this time in Caerphilly schools, culminating in a festival at the Caerphilly Centre of Sporting Excellence, Ystrad Mynach tomorrow. Plans are in place to set up a Disability Rugby Club in Newbridge to provide long-term playing opportunities.
WRU TV: Hear from inside the Wales camp as Neil Jenkins discusses this weekend's clash with South Africa and how the squad are looking to put in a strong performance to round of the 2016 Under Armour Series