Cardiff Blues coach Dai Young has rung the changes for his side's trip to the Liberty Stadium to face the Ospreys on Tuesday night (kick-off 7.35pm).
Having drawn 16-16 with the Magners League champions Leinster on the opening day of the season, the Blues now find themselves facing the EDF Energy Cup holders three days later.
And with Ulster coming to the Arms park on Friday night, making it three games in seven days, Young has stood down a number of first-choice players for the away trip.
"The Blues v Ospreys is obviously a big game in Wales, so it's a pity it's shoved in the middle of the week. We've only really had one day preparation for it which isn't ideal," explained Young.
"We've had to juggle teams because when you go from a Saturday game to a Tuesday match, the preparation is practically non existent.
"They have the same coaches who were there last year with Lyn, so we're expecting very much more of the same. Maybe they will make little changes here and there, but we know enough about their players and they know enough about us."
"I think both teams have a lot of skilful players, so I have no doubt that it will be a quality game. The Liberty Stadium is a great stadium to play at and I think the Ospreys are going to be up there at the end of the season.
"I know its going to be a big test for us."
There are nine new faces among the starting XV from the side that faced Leinster, with seven players, including new club skipper Paul Tito, reverting to bench duty. Welsh international Robin Sowden-Taylor returns to action for the first time since damaging his shoulder in March.
Cardiff Blues: Ben Blair; Richard Mustoe, Jamie Robinson, Jamie Roberts, Aled Brew; Ceri Sweeney, Darren Allinson; Taufa'ao Filise, T. Rhys Thomas, Gary Powell, Bradley Davies, Scott Morgan, Ben White, Robin Sowden-Taylor, Andy Powell.
Relacements: Gethin Jenkins, Gareth Williams, Paul Tito, Ma'ama Molitika, Jason Spice, Nicky Robinson, Tom Shanklin
Angus O'Brien has quickly settled into the Wales Sevens squad after solid performances in Hong Kong and Japan. With two rounds remaining in Glasgow and Twickenham on the World Series, WRU TV's Graeme Gillespie chats to the rising star.
Wales winger Luke Morgan has established himself as one of the deadliest finishers on the Sevens World Series. WRU TV's Graeme Gillespie catches up with him on the eve of this weekend's round in Glasgow.
All roads lead to Cardiff on Sunday for the SSE SWALEC Finals Day at the Millennium Stadium. Cambrian Welfare tackle Ystradgynlais in the Bowl final, Ystrad Rhondda play Newcastle Emlyn in the Plate final while defending champions Pontypridd face Bridgend in the Cup final.
WRU Chief Executive Roger Lewis, Deputy Minister for Culture, Sport and Tourism Ken Skates and WRU Chairman Gareth Davies earlier this week launched a new competition in conjunction with the WRU unveiling its archive room.
Welsh players and management joined Deputy Minister for Sport Ken Skates at the Pierhead Building, Cardiff Bay earlier this week to reveal the Union's pioneering school-club hub initiative has been so successful the project will now almost double the scale of the original project.
The Scarlets, Newport Gwent Dragons, Cardiff Blues and the Ospreys look ahead to Judgement Day III which sees the Blues take on the Ospreys (2.30) and the Dragons tackle the Scarlets (4.45pm) at the Millennium Stadium tomorrow afternoon.
Ystradgynlais and Ynysddu played out a titanic struggle at Taffs Well in the SSE SWALEC Bowl semi-final. At the end of the game neither team could be separated after a 15-15 stalemate but Ystradgynlais go through on try count.
Blues strike first in JD III battle - Newport Gwent Dragons lock Andrew Coombs, WRU referee Dylan Llyr Jones and Cardiff Blues hooker Matthew Rees decide dressing room allocations for Judgement Day III
Wales Under 18 captain Calum Haggett has received a conditional offer to read Biomedical Science at St Anne's College, Oxford. WRU chairman Gareth Davies went to meet Calum and Coleg y Cymoedd Principal Judith Evans to wish him luck in his exams and pass on some of his personal experience.