Richard Hodges is taking no chances with the cup challenge of Carmarthen Athletic by packing the side with his most experienced players.
Mark Roper starts at outside half with Jason Pocock coming in at fullback.
In the pack Matthew Bolton starts at prop, Nick Kelly resumes as captain in the second row and Richard Thomas and Mike Grimes both start.
The one survivor of the last time the two sides met is Mark O'Leary who is amongst the substitutes. The game also sees the return to the side of Lee Highgate who starts after an enforced layoff.
Glamorgan Wanderers: 15. Jason Pocock 14. Robin Lock 13. Ben Warbuton 12. James Thomas 11. Charlie Johnson 10. Mark Roper 9. Luke Evans; 1. Matthew Bolton 2. Ross Johnson 3. Scott Andrews 4. Nick Kelly (capt) 5. Tom Evans 6. Richard Thomas 7. Lee Highgate 8. Mike Grimes.
Replacements: 16. Richard Emms 17. Mark O'Leary 18. Ben Rose 19. Gareth Knight 20. Glenn Holloway 21. James Loxton 22. Steve Cullen
Wales head coach Warren Gatland and captain Sam Warburton say their first prioirty on Sunday in the opening game of the World Cup is to win against Uruguay and not get overly concerned with points difference.
With only days to go until the biggest rugby competition in the world begins, rugby fans visiting Cardiff this autumn will be able to enjoy a special display at National Museum Cardiff as part of the celebrations surrounding the Rugby World Cup.
Geraint John has taken up the new role of WRU elite coach development manager having arrived in Wales last week. WRU TV caught up with him at the WRU rugby department's strategy day at the Millennium Stadium.
The entire Welsh Rugby Union Rugby Department gathered at the Millennium Stadium earlier this week where WRU Head of Rugby Josh Lewsey looked back on a year where structural and strategic changes have seen significant progress made
The Welsh Rugby Union has released a specially produced video to spearhead a new campaign to help promote the values of rugby union. The video, entitled Let us Play underpins the WRU rugby department's philosophy - to engage, transfer and retain players, coaches and referees.