Richard Hodges is taking no chances with the cup challenge of Carmarthen Athletic by packing the side with his most experienced players.
Mark Roper starts at outside half with Jason Pocock coming in at fullback.
In the pack Matthew Bolton starts at prop, Nick Kelly resumes as captain in the second row and Richard Thomas and Mike Grimes both start.
The one survivor of the last time the two sides met is Mark O'Leary who is amongst the substitutes. The game also sees the return to the side of Lee Highgate who starts after an enforced layoff.
Glamorgan Wanderers: 15. Jason Pocock 14. Robin Lock 13. Ben Warbuton 12. James Thomas 11. Charlie Johnson 10. Mark Roper 9. Luke Evans; 1. Matthew Bolton 2. Ross Johnson 3. Scott Andrews 4. Nick Kelly (capt) 5. Tom Evans 6. Richard Thomas 7. Lee Highgate 8. Mike Grimes.
Replacements: 16. Richard Emms 17. Mark O'Leary 18. Ben Rose 19. Gareth Knight 20. Glenn Holloway 21. James Loxton 22. Steve Cullen
As the countdown continues for RWC2015, Tournament Chief Executive Debbie Jevans visited the Millennium Stadium to discuss preparations for the eight matches and reveal the positive news that 100,000 tickets for games at the home of Welsh rugby have sold in the last seven days.
Jason Harries is targeting a first win on the World Series circuit this season with Wales. The series returns to action this weekend in Dubai where Harries is part of a team hoping to build from its efforts in round one in October.
Wales skipper Jevon Groves says his side have addressed a few points from Gold Coast and aim to 'hit the ground running' in the next two rounds of the World Series, kicking off with this weekend in Dubai before heading off to South Africa next week.
Wales Sevens manager Steff Thomas is hopeful his side can build from a quarter-final spot in the opening round of the World Series in Australia when his side take part in the forthcoming double header in Dubai and South Africa.