Richard Hodges is taking no chances with the cup challenge of Carmarthen Athletic by packing the side with his most experienced players.
Mark Roper starts at outside half with Jason Pocock coming in at fullback.
In the pack Matthew Bolton starts at prop, Nick Kelly resumes as captain in the second row and Richard Thomas and Mike Grimes both start.
The one survivor of the last time the two sides met is Mark O'Leary who is amongst the substitutes. The game also sees the return to the side of Lee Highgate who starts after an enforced layoff.
Glamorgan Wanderers: 15. Jason Pocock 14. Robin Lock 13. Ben Warbuton 12. James Thomas 11. Charlie Johnson 10. Mark Roper 9. Luke Evans; 1. Matthew Bolton 2. Ross Johnson 3. Scott Andrews 4. Nick Kelly (capt) 5. Tom Evans 6. Richard Thomas 7. Lee Highgate 8. Mike Grimes.
Replacements: 16. Richard Emms 17. Mark O'Leary 18. Ben Rose 19. Gareth Knight 20. Glenn Holloway 21. James Loxton 22. Steve Cullen
The WRU has teamed up with Crawshay's to tour Georgia in June. The side, which will be called the Crawshays WRU President's XV, will play Emerging Georgia twice, in a tour which supports the Welsh Government's efforts to grow relations between the two countries.
Wales Sevens are looking to re-group after a disappointing tournament last time out in South Africa. The next double leg in New Zealand and Las Vegas offers Gareth Williams a chance to redeem themselves.
Wales Women's head coach Rhys Edwards was at Llandovery to see the conclusion of an entertaining Women's Regional championship where any one of three teams were in contention for title glory on the last day of action.
Christmas has come early at Glynneath rugby club, one of a number around Wales who have received an array of merchandise and equipment this December courtesy of the Welsh Rugby Union's £750,000 participation points scheme.
The WRU have been delivering on the scheme - which gives individual clubs access to up to £5,000 worth of supplies and equipment each for the 2014/2015 season - over the last two weeks and today (Friday) were received by a special guest in Glynneath, club president and pitch marker Max Boyce.