Richard Hodges is taking no chances with the cup challenge of Carmarthen Athletic by packing the side with his most experienced players.
Mark Roper starts at outside half with Jason Pocock coming in at fullback.
In the pack Matthew Bolton starts at prop, Nick Kelly resumes as captain in the second row and Richard Thomas and Mike Grimes both start.
The one survivor of the last time the two sides met is Mark O'Leary who is amongst the substitutes. The game also sees the return to the side of Lee Highgate who starts after an enforced layoff.
Glamorgan Wanderers: 15. Jason Pocock 14. Robin Lock 13. Ben Warbuton 12. James Thomas 11. Charlie Johnson 10. Mark Roper 9. Luke Evans; 1. Matthew Bolton 2. Ross Johnson 3. Scott Andrews 4. Nick Kelly (capt) 5. Tom Evans 6. Richard Thomas 7. Lee Highgate 8. Mike Grimes.
Replacements: 16. Richard Emms 17. Mark O'Leary 18. Ben Rose 19. Gareth Knight 20. Glenn Holloway 21. James Loxton 22. Steve Cullen
Wales Head Coach Rob Howley talks to WRU TV's Sebastian Barrett about the 36-man squad he has just named for the forthcoming Under Armour series, which includes two uncapped players, Ospreys duo Sam Davies and Rory Thornton.
Head coach Rowland Phillips is deligthed he can now call BT Sport Cardiff Arms Park home for his Wales Women's side, who launch their international season next month with games against Scotland and UK Armed Forces in the heart of the capital city.
Wales Sevens star Sam Cross has put his home town club of Brynmawr on the map after winning a silver medal at the Rio Olympics with Team GB. His club have now honoured him by naming their players bar after him, as WRU TV discovered at the official launch, recently.
One of the newest members of the Principality Premiership, Bargoed admit it's proving to be a steep learning curve at the highest level, but are determined to become a force to be reckoned with. WRU TV visited the club last weekend when they took on Llanelli.
Table-topping Aberavon travel to north Wales to tackle RGC 1404 as both teams defend unbeaten starts to the season in the Principality Premiership. WRU TV's Graeme Gillespie visited the Wizards to see how their preparations were going for the game of the weekend.
The Half a Game initiative is currently sweeping across Wales and proving a major success. The scheme aims to give every young player at least half a game every weekend. WRU TV recently visited a festival in Narberth where clubs have fully embraced the initiative.
Both Bargoed and Swansea were seeking their first win of the Principality Premiership season this afternoon. It proved a fruitful day for the hosts - not only did they win, but Bargoed claimed a try bonus point.
Cardiff managed to keep their unbeaten record at home intact, but only just as Bridgend made them work extremely hard before the Blue and Blacks secured a hard fought Principality Premiership win at the BT Sport Arms Park last night.
Former Wales back row Andy Powell gives a guided tour of The Wern, home of Merthyr RFC, who are determined to prove a lot of people wrong and make their mark in their first season in the Principality Premiership.