Prop Phil John replaces Iestyn Thomas (thumb) in the Scarlets side for the return clash against Ulster.
The Scarlets are down to the bare bones of a squad as Nigel Davies's side prepare to win their first game in Europe for the first time since March 2007.
The Scarlets, once proud flag bearers for the Welsh teams in Europe, haven't recorded a victory in the Heineken Cup in their last 10 games and face an Ulster side tomorrow night at Parc y Scarlets who are hoping to lay to rest their own bogey in the competition by recording a rare away victory.
With his squad already severely depleted, Davies has seen prop Iestyn Thomas forced out with a neck problem. His place will be taken by Phil John with young Aled Hopkins drafted in as cover from the ranks of Llanelli's Principality Premiership side.
Darren Daniel is one of two other changes. He replaces Ceiron Thomas on the right wing to make his 50th appearance for the Scarlets. Thomas drops down to the bench while Rhys Priestland replaces the injured Morgan Stoddart at full-back. Although a fly-half, Priestland is not entirely unfamiliar with the No15 shirt as he has played semi-pro rugby in that position.
After a lengthy spell on the sidelines, Scotland second row Scott MacLeod makes a welcome return to regional action and is named among the replacements.
Scarlets: R Priestland; D Daniel, R King, J Davies, M Jones; S Jones, M Roberts; P John, M Rees, D Manu, V Cooper, D Day, D Jones, S Easterby, D Lyons.
Replacements: K Owens, A Hopkins, S MacLeod, J Edwards, G Cattle, C Thomas, L Williams
Ulster Rugby: B Cunningham; A Trimble, D Cave, P Wallace, S Danielli; I Humphreys, I Boss; J Fitzpatrick, R Best [capt], B Botha, E O'Donoghue, R Caldwell, S Ferris, D Pollock, R Diack
Replacements: N Brady, T Court, M McCullough, K Dawson, P Marshall, P Steinmetz, C Schifcofske.
When the Wales squad were asked to nominate individuals who played a big part in their early playing days, Wales and Dragons full back and wing Hallam Amos thought of his former Monmouth School rugby coach John Bevan.
Sam Cross and Luke Treharne have been named as co-captains of the Wales Sevens side as head coach Gareth Williams names his 12-man squad to play in the first leg of the HSBC World Series in Dubai next weekend.
Bedwas head coach Steve Law and players Nicky Griffiths and Alun Rees extol the virtues of the close knit club as they prepare to host third place RGC 1404 - who are one place head of them on the Principality Premiership points table - on Saturday.
Many of the Wales squad have said Diolch (thank you) to someone who played an important part in their early playing days by nominating them to be invited to the Wales v South Africa match. One person, Gowerton Comprehensive geography teacher Mr Dean Mason was nominated by two of his former pupils, Dan Biggar and Sam Davies.
The second WRU disability rugby pilot has been delivered, this time in Caerphilly schools, culminating in a festival at the Caerphilly Centre of Sporting Excellence, Ystrad Mynach tomorrow. Plans are in place to set up a Disability Rugby Club in Newbridge to provide long-term playing opportunities.
WRU TV: Hear from inside the Wales camp as Neil Jenkins discusses this weekend's clash with South Africa and how the squad are looking to put in a strong performance to round of the 2016 Under Armour Series