Prop Phil John replaces Iestyn Thomas (thumb) in the Scarlets side for the return clash against Ulster.
The Scarlets are down to the bare bones of a squad as Nigel Davies's side prepare to win their first game in Europe for the first time since March 2007.
The Scarlets, once proud flag bearers for the Welsh teams in Europe, haven't recorded a victory in the Heineken Cup in their last 10 games and face an Ulster side tomorrow night at Parc y Scarlets who are hoping to lay to rest their own bogey in the competition by recording a rare away victory.
With his squad already severely depleted, Davies has seen prop Iestyn Thomas forced out with a neck problem. His place will be taken by Phil John with young Aled Hopkins drafted in as cover from the ranks of Llanelli's Principality Premiership side.
Darren Daniel is one of two other changes. He replaces Ceiron Thomas on the right wing to make his 50th appearance for the Scarlets. Thomas drops down to the bench while Rhys Priestland replaces the injured Morgan Stoddart at full-back. Although a fly-half, Priestland is not entirely unfamiliar with the No15 shirt as he has played semi-pro rugby in that position.
After a lengthy spell on the sidelines, Scotland second row Scott MacLeod makes a welcome return to regional action and is named among the replacements.
Scarlets: R Priestland; D Daniel, R King, J Davies, M Jones; S Jones, M Roberts; P John, M Rees, D Manu, V Cooper, D Day, D Jones, S Easterby, D Lyons.
Replacements: K Owens, A Hopkins, S MacLeod, J Edwards, G Cattle, C Thomas, L Williams
Ulster Rugby: B Cunningham; A Trimble, D Cave, P Wallace, S Danielli; I Humphreys, I Boss; J Fitzpatrick, R Best [capt], B Botha, E O'Donoghue, R Caldwell, S Ferris, D Pollock, R Diack
Replacements: N Brady, T Court, M McCullough, K Dawson, P Marshall, P Steinmetz, C Schifcofske.
The last five years have been an emotional rollercoaster on and off the pitch for RGC1404. Promotion to the Principality Premiership was the culmination of five years of hard work and investment in North Wales. WRU TV caught up with prop Joe Simpson, who was one of the first intake of WRU North Wales Academy players in 2010.
Ebbw Vale captain Damien Hudd picked up the biggest accolade of the night at the 11th Principality Premiership Awards Evening held at Principality Stadium, after leading his side to the title for the first time.
Wales assistant coach Robin McBryde is predicting a tough battle against England on Sunday despite the fact they may not be considered to be at full strength. Players will be out to impress Eddie Jones which makes England a dangerous proposition, he says.
Wales U20 captain Tom Phillips and performance psychologist Dr Rich Neil explain why spending three days at Monmouth RFC has further strengthened the togetherness of the squad ahead of the #WorldRugbyU20s