Blues rising star Leigh Halfpenny will play his second game at full-back for David Young's side.
Cardiff Blues are hoping to throw down a marker at Parc y Scarlets tomorrow by recording a Magners League victory in their first visit at the Scarlets new home - and if they achieve that feat David Young's squad are confident of coming out of the festive period as the best place Welsh region in the competition.
The Blues have impressed in Europe this season and after a hectic past few weeks of international and Heineken Cup action, Young has taken the decision to rest several of his key players.
Welsh internationals Martyn Williams, Gethin Jenkins, Tom Shanklin and Andy Powell have all been given a well earned rest while Kiwi fullback Ben Blair and inspirational second row Paul Tito have also been given time off.
Leigh Halfpenny makes his second start for the Blues at full back with young scrum half Darren Allinson also starting for the third time.
In the forwards, there is new partnership in the second row with Scott Morgan and Bradley Davies starting. The back row also has a new feel with Maama Molitika starting at No 8, Ben White at 6 and Robin Sowden Taylor, captaining the side at openside flanker.
Although he will be watching from the sidelines for the first of the Welsh derbies, Jenkins is confident the Blues have the firepower to make their mark.
"We definitely want to be the top Welsh region, whether it be in the Magners League competition or the Heineken Cup," he said.
"We have not had a good start in the Magners League, but we will be looking to address our position in the next three Welsh derbies.
"They are tough affairs and they are always pretty scrappy, but we are going out there to get a few wins. We have a good squad and they can go out and do a job over Christmas, starting with the match at the Scarlets tomorrow evening."
15 Leigh Halfpenny 14 Richard Mustoe 13 Jamie Robinson 12 Gareth Thomas 11 Tom James 10 Ceri Sweeney 9 Darren Allinson; 8 Maama Molitika 7 Robin Sowden Taylor (capt) 6 Ben White 5 Scott Morgan 4 Bradley Davies 3 Taufa'au Filise 2 T Rhys Thomas 1 John Yapp
Replacements: 16 Gary Powell 17 Gareth Williams 18 Deiniol Jones 19 Damian Welch 20 Jason Spice 21 Nicky Robinson 22 Chris Czekaj
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Wales Sevens are looking to re-group after a disappointing tournament last time out in South Africa. The next double leg in New Zealand and Las Vegas offers Gareth Williams a chance to redeem themselves.
Wales Women's head coach Rhys Edwards was at Llandovery to see the conclusion of an entertaining Women's Regional championship where any one of three teams were in contention for title glory on the last day of action.