Blues rising star Leigh Halfpenny will play his second game at full-back for David Young's side.
Cardiff Blues are hoping to throw down a marker at Parc y Scarlets tomorrow by recording a Magners League victory in their first visit at the Scarlets new home - and if they achieve that feat David Young's squad are confident of coming out of the festive period as the best place Welsh region in the competition.
The Blues have impressed in Europe this season and after a hectic past few weeks of international and Heineken Cup action, Young has taken the decision to rest several of his key players.
Welsh internationals Martyn Williams, Gethin Jenkins, Tom Shanklin and Andy Powell have all been given a well earned rest while Kiwi fullback Ben Blair and inspirational second row Paul Tito have also been given time off.
Leigh Halfpenny makes his second start for the Blues at full back with young scrum half Darren Allinson also starting for the third time.
In the forwards, there is new partnership in the second row with Scott Morgan and Bradley Davies starting. The back row also has a new feel with Maama Molitika starting at No 8, Ben White at 6 and Robin Sowden Taylor, captaining the side at openside flanker.
Although he will be watching from the sidelines for the first of the Welsh derbies, Jenkins is confident the Blues have the firepower to make their mark.
"We definitely want to be the top Welsh region, whether it be in the Magners League competition or the Heineken Cup," he said.
"We have not had a good start in the Magners League, but we will be looking to address our position in the next three Welsh derbies.
"They are tough affairs and they are always pretty scrappy, but we are going out there to get a few wins. We have a good squad and they can go out and do a job over Christmas, starting with the match at the Scarlets tomorrow evening."
15 Leigh Halfpenny 14 Richard Mustoe 13 Jamie Robinson 12 Gareth Thomas 11 Tom James 10 Ceri Sweeney 9 Darren Allinson; 8 Maama Molitika 7 Robin Sowden Taylor (capt) 6 Ben White 5 Scott Morgan 4 Bradley Davies 3 Taufa'au Filise 2 T Rhys Thomas 1 John Yapp
Replacements: 16 Gary Powell 17 Gareth Williams 18 Deiniol Jones 19 Damian Welch 20 Jason Spice 21 Nicky Robinson 22 Chris Czekaj
The Webb Ellis Cup visited Lampeter on Monday to recognise the fact that the town is celebrating a major milestone as it is believed the first ever game of rugby played in Wales, was in fact played in Lampeter 150 years ago.
Cardiff Blues U18 Girls will go into Sunday's Gemau Cymru with an extra spring in their step after Welsh internationals Elinor Snowsill and Philippa Tuttiett offered some last minute tips at a training session earlier this week.
Rob Howley and Josh Lewsey addressed more than 250 community club coaches and referees at the first WRU National Community Conference on the weekend. The volunteers benefitted from coaching masterclasses and workshops in a bid to connect all levels of the rugby pathway in Wales.
UEFA has today confirmed the Football Association of Wales (FAW) has been successful in its bid for the Millennium Stadium to host the 2017 UEFA Champions League Final on Saturday 3rd June, 2017 (kick-off: 19.45hrs GMT).
The winners of a filmmaking competition organised by the education charity Into Film and the WRU enjoyed a behind the scenes tour of the Millennium Stadium - and a chance to be photographed with the WRU's fire-breathing, rugby loving mascot, Scorch The Dragon, and Welsh international, Jake Ball.