Blues rising star Leigh Halfpenny will play his second game at full-back for David Young's side.
Cardiff Blues are hoping to throw down a marker at Parc y Scarlets tomorrow by recording a Magners League victory in their first visit at the Scarlets new home - and if they achieve that feat David Young's squad are confident of coming out of the festive period as the best place Welsh region in the competition.
The Blues have impressed in Europe this season and after a hectic past few weeks of international and Heineken Cup action, Young has taken the decision to rest several of his key players.
Welsh internationals Martyn Williams, Gethin Jenkins, Tom Shanklin and Andy Powell have all been given a well earned rest while Kiwi fullback Ben Blair and inspirational second row Paul Tito have also been given time off.
Leigh Halfpenny makes his second start for the Blues at full back with young scrum half Darren Allinson also starting for the third time.
In the forwards, there is new partnership in the second row with Scott Morgan and Bradley Davies starting. The back row also has a new feel with Maama Molitika starting at No 8, Ben White at 6 and Robin Sowden Taylor, captaining the side at openside flanker.
Although he will be watching from the sidelines for the first of the Welsh derbies, Jenkins is confident the Blues have the firepower to make their mark.
"We definitely want to be the top Welsh region, whether it be in the Magners League competition or the Heineken Cup," he said.
"We have not had a good start in the Magners League, but we will be looking to address our position in the next three Welsh derbies.
"They are tough affairs and they are always pretty scrappy, but we are going out there to get a few wins. We have a good squad and they can go out and do a job over Christmas, starting with the match at the Scarlets tomorrow evening."
15 Leigh Halfpenny 14 Richard Mustoe 13 Jamie Robinson 12 Gareth Thomas 11 Tom James 10 Ceri Sweeney 9 Darren Allinson; 8 Maama Molitika 7 Robin Sowden Taylor (capt) 6 Ben White 5 Scott Morgan 4 Bradley Davies 3 Taufa'au Filise 2 T Rhys Thomas 1 John Yapp
Replacements: 16 Gary Powell 17 Gareth Williams 18 Deiniol Jones 19 Damian Welch 20 Jason Spice 21 Nicky Robinson 22 Chris Czekaj
Angus O'Brien has quickly settled into the Wales Sevens squad after solid performances in Hong Kong and Japan. With two rounds remaining in Glasgow and Twickenham on the World Series, WRU TV's Graeme Gillespie chats to the rising star.
Wales winger Luke Morgan has established himself as one of the deadliest finishers on the Sevens World Series. WRU TV's Graeme Gillespie catches up with him on the eve of this weekend's round in Glasgow.
All roads lead to Cardiff on Sunday for the SSE SWALEC Finals Day at the Millennium Stadium. Cambrian Welfare tackle Ystradgynlais in the Bowl final, Ystrad Rhondda play Newcastle Emlyn in the Plate final while defending champions Pontypridd face Bridgend in the Cup final.
WRU Chief Executive Roger Lewis, Deputy Minister for Culture, Sport and Tourism Ken Skates and WRU Chairman Gareth Davies earlier this week launched a new competition in conjunction with the WRU unveiling its archive room.
Welsh players and management joined Deputy Minister for Sport Ken Skates at the Pierhead Building, Cardiff Bay earlier this week to reveal the Union's pioneering school-club hub initiative has been so successful the project will now almost double the scale of the original project.
The Scarlets, Newport Gwent Dragons, Cardiff Blues and the Ospreys look ahead to Judgement Day III which sees the Blues take on the Ospreys (2.30) and the Dragons tackle the Scarlets (4.45pm) at the Millennium Stadium tomorrow afternoon.
Ystradgynlais and Ynysddu played out a titanic struggle at Taffs Well in the SSE SWALEC Bowl semi-final. At the end of the game neither team could be separated after a 15-15 stalemate but Ystradgynlais go through on try count.
Blues strike first in JD III battle - Newport Gwent Dragons lock Andrew Coombs, WRU referee Dylan Llyr Jones and Cardiff Blues hooker Matthew Rees decide dressing room allocations for Judgement Day III
Wales Under 18 captain Calum Haggett has received a conditional offer to read Biomedical Science at St Anne's College, Oxford. WRU chairman Gareth Davies went to meet Calum and Coleg y Cymoedd Principal Judith Evans to wish him luck in his exams and pass on some of his personal experience.