Gavin Henson will start at full-back for the Ospreys.
The Ospreys will be seeking to carry their Heineken Cup form into tomorrow's Magners League clash against Newport Gwent Dragons at Rodney Parade.
Sean Holley's side are on top of Pool 3 at the conclusion of four rounds in the European Cup and have looked a class outfit but the first of the Welsh derbies taking place over the festive period is an intriguing prospect as the Dragons have improved considerably over recent weeks, even if results don't reflect their efforts.
The Ospreys have rested Shane Williams, Lee Byrne, James Hook and Alun-wyn Jones for the contest but Holley is confident the players coming in will do justice to the cause.
"Everybody within the camp is looking forward to the start of the traditional Christmas derbies. It's always an exciting time, for players, coaches and supporters alike, when traditional rivalries are played out in front of big crowds, with a great atmosphere and local pride at stake. We don't expect the next few weeks to be any different, starting at Rodney Parade.
"We've taken the decision to rest a few of our international players for this week. Players like Shane Williams, Lee Byrne, James Hook and Alun-wyn Jones have had a lot of rugby recently, and will do so over the coming months, but we felt that the time was appropriate to allow them some time off. All season long we've looked to rotate players, to ensure that they remain fresh and to help develop the depth of the squad and this is just an extension of that policy.
"We are able to do this because of the faith that we have in the squad as a whole, and in fact, the form of some of the young players warrants selection in itself. The likes of Tom Smith, Dan Biggar, Kristian Phillips and Ed Shervington epitomise this, and in Marc Breeze and Ashley Beck we have two of the most consistent players in the Welsh Premiership this season. We also have the likes of Ryan Jones, Gavin Henson and Mike Phillips available again which has increased our options so we're confident that our 22 will deliver the performance we want."
Following tomorrow night's clash, the Ospreys then face another Welsh derby on Saturday December 27 when they host arch rivals Scarlets before taking on Cardiff Blues on New Year's Eve.
Ospreys: 15 Gavin Henson 14 Tommy Bowe 13 Sonny Parker 12 Andrew Bishop 11 Jonny Vaughton 10 Dan Biggar 9 Rhodri Wells; 8 Ryan Jones (capt), 7 Marty Holah 6 Tom Smith 5 Jonathan Thomas 4 Ian Gough 3 Cai Griffiths 2 Ed Shervington 1 Paul James
Replacements: 16 Marc Breeze 17 Adam Jones 18 Filo Tiatia 19 Steve Tandy 20 Mike Phillips 21 Ashley Beck 22 Kristian Phillips
Wales U20 captain Tom Phillips and performance psychologist Dr Rich Neil explain why spending three days at Monmouth RFC has further strengthened the togetherness of the squad ahead of the #WorldRugbyU20s
Alongside Scarlets flanker James Davies and Cardiff Blues centre Cory Allen, three Wales Sevens core players have made the extended training squad for GB Sevens. Wales Head coach Gareth Williams tells WRU TV's Graeme Gillespie why Luke Treharne, Sam Cross and Luke Morgan earned selection in the initial training squad for Rio.
Wales Sevens head coach Gareth Williams tells WRU TV's Graeme Gillespie he has had to overcome a number of injuries before naming a competitive squad for this weekend's penultimate round of the World Series in Paris.
Merthyr were officially crowned champions of the SSE SWALEC Championship at Dowlais on Saturday where captain Andy Powell paid tribute to his side who have earned promotion to the Principality Premiership
Coleg y Cymoedd's season has had a spectacular ending with victory in two cup finals and a massive victory over one of the best rugby playing schools in the world - Welsh coach Warren Gatland's old alma mater, Hamilton Boys' High School.
WRU chief executive Martyn Phillips hosted the second meeting of the WRU Youth Board last weekend ahead of the Judgement Day IV regional double-header. Tthe board, made up of 15 under-21-year-olds from around Wales, heard presentations from head of participation Ryan Jones, policy and integrity manager Jeremy Rogers and national women's rugby manager Caroline Spanton, with Pro Rugby Wales CEO Mark Davies also on hand to hear the range of views aired.
Wales duo Rhun Williams and Liam Belcher, who makes a welcome return after five months of injury woe, look ahead to next month's World Rugby U20 Championship in Manchester where they will face Ireland, Georgia and New Zealand.