Gavin Henson will start at full-back for the Ospreys.
The Ospreys will be seeking to carry their Heineken Cup form into tomorrow's Magners League clash against Newport Gwent Dragons at Rodney Parade.
Sean Holley's side are on top of Pool 3 at the conclusion of four rounds in the European Cup and have looked a class outfit but the first of the Welsh derbies taking place over the festive period is an intriguing prospect as the Dragons have improved considerably over recent weeks, even if results don't reflect their efforts.
The Ospreys have rested Shane Williams, Lee Byrne, James Hook and Alun-wyn Jones for the contest but Holley is confident the players coming in will do justice to the cause.
"Everybody within the camp is looking forward to the start of the traditional Christmas derbies. It's always an exciting time, for players, coaches and supporters alike, when traditional rivalries are played out in front of big crowds, with a great atmosphere and local pride at stake. We don't expect the next few weeks to be any different, starting at Rodney Parade.
"We've taken the decision to rest a few of our international players for this week. Players like Shane Williams, Lee Byrne, James Hook and Alun-wyn Jones have had a lot of rugby recently, and will do so over the coming months, but we felt that the time was appropriate to allow them some time off. All season long we've looked to rotate players, to ensure that they remain fresh and to help develop the depth of the squad and this is just an extension of that policy.
"We are able to do this because of the faith that we have in the squad as a whole, and in fact, the form of some of the young players warrants selection in itself. The likes of Tom Smith, Dan Biggar, Kristian Phillips and Ed Shervington epitomise this, and in Marc Breeze and Ashley Beck we have two of the most consistent players in the Welsh Premiership this season. We also have the likes of Ryan Jones, Gavin Henson and Mike Phillips available again which has increased our options so we're confident that our 22 will deliver the performance we want."
Following tomorrow night's clash, the Ospreys then face another Welsh derby on Saturday December 27 when they host arch rivals Scarlets before taking on Cardiff Blues on New Year's Eve.
Ospreys: 15 Gavin Henson 14 Tommy Bowe 13 Sonny Parker 12 Andrew Bishop 11 Jonny Vaughton 10 Dan Biggar 9 Rhodri Wells; 8 Ryan Jones (capt), 7 Marty Holah 6 Tom Smith 5 Jonathan Thomas 4 Ian Gough 3 Cai Griffiths 2 Ed Shervington 1 Paul James
Replacements: 16 Marc Breeze 17 Adam Jones 18 Filo Tiatia 19 Steve Tandy 20 Mike Phillips 21 Ashley Beck 22 Kristian Phillips
Wales and Ospreys back row James King, who came through the North Wales age grade system, nominated North Wales Regional Community Rugby Manager Marc Roberts, in the WRU's 'Diolch' initiative where squad players thanked those who played a part in their rise to the top.
Beating Merthyr has boosted Carmarthen Quins hopes of reaching a top eight spot in the Principality Premiership. Quins captain Haydn Pugh is delighted with his team's progress and is determined that everyone from the Under 6s through to the senior team, enjoys the ride.
When the Wales squad were asked to nominate individuals who played a big part in their early playing days, Wales and Dragons full back and wing Hallam Amos thought of his former Monmouth School rugby coach John Bevan.
Sam Cross and Luke Treharne have been named as co-captains of the Wales Sevens side as head coach Gareth Williams names his 12-man squad to play in the first leg of the HSBC World Series in Dubai next weekend.
Bedwas head coach Steve Law and players Nicky Griffiths and Alun Rees extol the virtues of the close knit club as they prepare to host third place RGC 1404 - who are one place head of them on the Principality Premiership points table - on Saturday.
Many of the Wales squad have said Diolch (thank you) to someone who played an important part in their early playing days by nominating them to be invited to the Wales v South Africa match. One person, Gowerton Comprehensive geography teacher Mr Dean Mason was nominated by two of his former pupils, Dan Biggar and Sam Davies.
The second WRU disability rugby pilot has been delivered, this time in Caerphilly schools, culminating in a festival at the Caerphilly Centre of Sporting Excellence, Ystrad Mynach tomorrow. Plans are in place to set up a Disability Rugby Club in Newbridge to provide long-term playing opportunities.
WRU TV: Hear from inside the Wales camp as Neil Jenkins discusses this weekend's clash with South Africa and how the squad are looking to put in a strong performance to round of the 2016 Under Armour Series