Gavin Henson will start his first game in six months for the Ospreys when he faces Harlequins in the EDF Energy Cup this Sunday.
Henson, 26, has been named by the defending champions at centre for the Liberty Stadium clash.
The British Lions and Wales star produced a 20-minute cameo appearance against Ulster last weekend following ankle surgery and has been passed fit to start.
Coach Sean Holley said: "We need to see Gavin start a game and how he contributes to a match. He's been excellent in training and looks superbly big, strong, fast and powerful.
"But it's a lot to ask for him to play a couple of games and then be thrown into a major European competition. We will see how he responds.
"I'm excited to have him back on the field and we all know what Gavin can do. It could be a big season for him."
Henson is joined in the centre by fit-again Sonny Parker in a strong line-up containing 13 internationals but Wales forwards Ian Evans and Jonathan Thomas are rested.
Ospreys: L Byrne; J Vaughton, S Parker, G Henson, S Williams, J Hook, R Webb; D Jones, H Bennett, A Jones, I Gough, AW Jones, F Tiatia, R Jones (capt), M Holah Replacements: R Hibbard, A Millward, L Bateman, S Tandy, T Smith, D Biggar, T Bowe
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