Gavin Henson will start his first game in six months for the Ospreys when he faces Harlequins in the EDF Energy Cup this Sunday.
Henson, 26, has been named by the defending champions at centre for the Liberty Stadium clash.
The British Lions and Wales star produced a 20-minute cameo appearance against Ulster last weekend following ankle surgery and has been passed fit to start.
Coach Sean Holley said: "We need to see Gavin start a game and how he contributes to a match. He's been excellent in training and looks superbly big, strong, fast and powerful.
"But it's a lot to ask for him to play a couple of games and then be thrown into a major European competition. We will see how he responds.
"I'm excited to have him back on the field and we all know what Gavin can do. It could be a big season for him."
Henson is joined in the centre by fit-again Sonny Parker in a strong line-up containing 13 internationals but Wales forwards Ian Evans and Jonathan Thomas are rested.
Ospreys: L Byrne; J Vaughton, S Parker, G Henson, S Williams, J Hook, R Webb; D Jones, H Bennett, A Jones, I Gough, AW Jones, F Tiatia, R Jones (capt), M Holah Replacements: R Hibbard, A Millward, L Bateman, S Tandy, T Smith, D Biggar, T Bowe
Whenever Bedlinog tackle Penallta a massive fixure is guaranteed but this Sunday there will be even more emphasis placed on the two rivals when they contest the SSE Swalec Plate final at Principality Stadium.
Ahead of their SSE SWALEC Bowl Final clash with Taffs Well at Principality Stadium on Sunday, Burry Port share their #FABXV nomination with WRUTV in the search for Welsh rugby's greatest volunteers. Everyone can get involved by sending nominations via twitter to @WRU_Community using the hashtag #FABXV
Cardiff Blues prop Gethin Jenkins and Ospreys centre Ben John look ahead to the first game at Principality Stadium in Saturday's double header which is promising to be a special occasion for all Welsh fans.
Carmarthen Quins Director of Rugby Ian Jones and committee member Jeff Thomas along with Llandovery chairman Handel Davies look ahead to Sunday's SSE SWALEC Cup showdown where both teams are out to prove 'West is best'
SWALEC ambassador Shane WIlliams is looking forward to Sunday's Finals Day where the Cup, Bowl and Plate offers a great opportunity for players and teams to experience the magic of playing at Principality Stadium
Carmarthen Quins coach Richard Kelly believes it is an exciting time to be part of the Scarlets region as his side take on local rivals Llandovery in the SSE Swalec Cup final on Sunday, as WRU TV's Graeme Gillespie discovers