Gavin Henson will start his first game in six months for the Ospreys when he faces Harlequins in the EDF Energy Cup this Sunday.
Henson, 26, has been named by the defending champions at centre for the Liberty Stadium clash.
The British Lions and Wales star produced a 20-minute cameo appearance against Ulster last weekend following ankle surgery and has been passed fit to start.
Coach Sean Holley said: "We need to see Gavin start a game and how he contributes to a match. He's been excellent in training and looks superbly big, strong, fast and powerful.
"But it's a lot to ask for him to play a couple of games and then be thrown into a major European competition. We will see how he responds.
"I'm excited to have him back on the field and we all know what Gavin can do. It could be a big season for him."
Henson is joined in the centre by fit-again Sonny Parker in a strong line-up containing 13 internationals but Wales forwards Ian Evans and Jonathan Thomas are rested.
Ospreys: L Byrne; J Vaughton, S Parker, G Henson, S Williams, J Hook, R Webb; D Jones, H Bennett, A Jones, I Gough, AW Jones, F Tiatia, R Jones (capt), M Holah Replacements: R Hibbard, A Millward, L Bateman, S Tandy, T Smith, D Biggar, T Bowe
As the countdown continues for RWC2015, Tournament Chief Executive Debbie Jevans visited the Millennium Stadium to discuss preparations for the eight matches and reveal the positive news that 100,000 tickets for games at the home of Welsh rugby have sold in the last seven days.
Jason Harries is targeting a first win on the World Series circuit this season with Wales. The series returns to action this weekend in Dubai where Harries is part of a team hoping to build from its efforts in round one in October.
Wales skipper Jevon Groves says his side have addressed a few points from Gold Coast and aim to 'hit the ground running' in the next two rounds of the World Series, kicking off with this weekend in Dubai before heading off to South Africa next week.
Wales Sevens manager Steff Thomas is hopeful his side can build from a quarter-final spot in the opening round of the World Series in Australia when his side take part in the forthcoming double header in Dubai and South Africa.