In the pack Rhys Gill comes in for Nathan Trevett and Gareth Knight gets his first start of the season in the second row to partner Tom Evans.
Coach Richard Hodges also introduces Luke Fear and Andrew Cawley to the bench for the first time this season while Gareth Morris takes over the captaincy.
Glamorgan Wanderers: 15. James Loxton, 14. Steve Cullen, 13. Robin Lock, 12. Gareth Morris (capt), 11. Jason Pocock, 10. Scott Sneddon, 9. Luke Evans.
1. Rhys Gill, 2. Ryan Price, 3. Scott Andrews, 4. Gareth Knight, 5. Tom Evans, 6. Nio Aiono, 7. Lee Highgate, 8. Alistair McDonald.
Replacements: 16. Mark Sheppard, 17. Nathan Trevett, 18. Richard Thomas, 19. Mike Grimes, 20. Luke Fear, 21. Andrew Cawley, 22. Mark Roper.