Glamorgan Wanderers make one change in the backs and two up front for trip to Sardis Road.
Jason Pocock, after missing the Cross Keys victory, returns to the wing. It will be his first return to Pontypridd after transferring back to the Wanderers from Ponty in the summer.
In the pack Rhys Gill comes in for Nathan Trevett and Gareth Knight gets his first start of the season in the second row to partner Tom Evans.
Coach Richard Hodges also introduces Luke Fear and Andrew Cawley to the bench for the first time this season while Gareth Morris takes over the captaincy.
Glamorgan Wanderers: 15. James Loxton, 14. Steve Cullen, 13. Robin Lock, 12. Gareth Morris (capt), 11. Jason Pocock, 10. Scott Sneddon, 9. Luke Evans.
1. Rhys Gill, 2. Ryan Price, 3. Scott Andrews, 4. Gareth Knight, 5. Tom Evans, 6. Nio Aiono, 7. Lee Highgate, 8. Alistair McDonald.
Replacements: 16. Mark Sheppard, 17. Nathan Trevett, 18. Richard Thomas, 19. Mike Grimes, 20. Luke Fear, 21. Andrew Cawley, 22. Mark Roper.
Beating Merthyr has boosted Carmarthen Quins hopes of reaching a top eight spot in the Principality Premiership. Quins captain Haydn Pugh is delighted with his team's progress and is determined that everyone from the Under 6s through to the senior team, enjoys the ride.
When the Wales squad were asked to nominate individuals who played a big part in their early playing days, Wales and Dragons full back and wing Hallam Amos thought of his former Monmouth School rugby coach John Bevan.
Sam Cross and Luke Treharne have been named as co-captains of the Wales Sevens side as head coach Gareth Williams names his 12-man squad to play in the first leg of the HSBC World Series in Dubai next weekend.
Bedwas head coach Steve Law and players Nicky Griffiths and Alun Rees extol the virtues of the close knit club as they prepare to host third place RGC 1404 - who are one place head of them on the Principality Premiership points table - on Saturday.
Many of the Wales squad have said Diolch (thank you) to someone who played an important part in their early playing days by nominating them to be invited to the Wales v South Africa match. One person, Gowerton Comprehensive geography teacher Mr Dean Mason was nominated by two of his former pupils, Dan Biggar and Sam Davies.
The second WRU disability rugby pilot has been delivered, this time in Caerphilly schools, culminating in a festival at the Caerphilly Centre of Sporting Excellence, Ystrad Mynach tomorrow. Plans are in place to set up a Disability Rugby Club in Newbridge to provide long-term playing opportunities.
WRU TV: Hear from inside the Wales camp as Neil Jenkins discusses this weekend's clash with South Africa and how the squad are looking to put in a strong performance to round of the 2016 Under Armour Series