However, with the Dragons having registered their first win of the season - 18-12 against North Wales 10 days ago - the Blues are likely to have their work cut out.
In the other game, the Scarlets will also find it difficult on their travels - they face high-flying Blues South at Taffs Well.
Having lost their first game of the season at Blues North, the Scarlets have bagged impressive wins over the Ospreys, Dragons and North Wales to remain hot on the heels of the leaders.
Blues South too have been in decent form with two wins in four games. They lost 14-8 to the Ospreys last time out and will be keen to put their season back at track on home soil.
Blues North: C Edwards; S Webber, R Evans, T Pascoe, O Rees; L Williams, L Jones; D Harris, J Dando, T Jones, L Young, A Lee, T Davies, C Thomas, W Griff John. Replacements: B Thyre, J Elley, M Screech, J Perkins, D Jones, G Thomas, T Priest
Blues South: R Patchell; H Robinson, M Roberts, JB Bruziller (capt), C Driscoll; J Morris, T O'Brien; C Hole, J Hopkins, M Taylor, E Chilcott, B Smith, L Jones, L O'Brien, R Tucker. Replacements: R Rowley, A Rees, P Lloyd, S Bennett, R Phillips, I Matthews, J Hurley, D Young, P King
Scarlets: L Treharne; G Hunter, L Harvatt, R James, P Rushesha; J Williams, R Williams; N Bowen, S O'Leary, S Lee, D Evans, J Gardiner, R Bloomfield (capt), O Powell, C Morris. Replacements: G Thomas, A Williams, L Evans, J Iles, S Maynard, R Evans, M Jenkins