Llanelli take their unbeaten record in the Principality Premier Division to Pandy Park where Cross Keys will be hoping to improve on their home record.
After defeating Swansea by a point, they were beaten by visitors Ebbw Vale by just two points but, with only five tries in the bag to date, they may find the Llanelli outfit too strong.
Leading try scorers Neath host Newport at the Gnoll having won their previous three home matches. The Black and Ambers have won all four matches to date and will be full of confidence against the Welsh All Blacks.
If the Scarlets slip, Aberavon are well-placed to take over at the top. They travel to a Bedwas side without a victory after drawing their first match of the season. The Wizards whitewashed Pooler last week and will be looking to hand out more misery at the Bridge Field.
Bridgend are three points ahead of visitors Swansea and a victory for the Ravens should keep them up amongst the leaders.
Both Cardiff and Ebbw Vale have had poor starts to the season but home advantage should see the Arms Park outfit home against the Steelmen. Both sides have only crossed for seven tries so it could all come down to the boot.
Bottom club Llandovery only have one bonus point to show for their efforts this season. They travel to Pontypool Park looking to improve that poor record. The Drovers only have four tries from their five outings and may be another side relying on kicks to keep them in the game.
The final match is at Sardis Road where Pontypridd entertain Glamorgan Wanderers. The Cardiff-based side can usually be relied upon to score points, but Ponty did the double over Wanderers last term.
Wales Head Coach Rob Howley talks to WRU TV's Sebastian Barrett about the 36-man squad he has just named for the forthcoming Under Armour series, which includes two uncapped players, Ospreys duo Sam Davies and Rory Thornton.
Head coach Rowland Phillips is deligthed he can now call BT Sport Cardiff Arms Park home for his Wales Women's side, who launch their international season next month with games against Scotland and UK Armed Forces in the heart of the capital city.
Wales Sevens star Sam Cross has put his home town club of Brynmawr on the map after winning a silver medal at the Rio Olympics with Team GB. His club have now honoured him by naming their players bar after him, as WRU TV discovered at the official launch, recently.
One of the newest members of the Principality Premiership, Bargoed admit it's proving to be a steep learning curve at the highest level, but are determined to become a force to be reckoned with. WRU TV visited the club last weekend when they took on Llanelli.
Table-topping Aberavon travel to north Wales to tackle RGC 1404 as both teams defend unbeaten starts to the season in the Principality Premiership. WRU TV's Graeme Gillespie visited the Wizards to see how their preparations were going for the game of the weekend.
The Half a Game initiative is currently sweeping across Wales and proving a major success. The scheme aims to give every young player at least half a game every weekend. WRU TV recently visited a festival in Narberth where clubs have fully embraced the initiative.
Both Bargoed and Swansea were seeking their first win of the Principality Premiership season this afternoon. It proved a fruitful day for the hosts - not only did they win, but Bargoed claimed a try bonus point.
Cardiff managed to keep their unbeaten record at home intact, but only just as Bridgend made them work extremely hard before the Blue and Blacks secured a hard fought Principality Premiership win at the BT Sport Arms Park last night.
Former Wales back row Andy Powell gives a guided tour of The Wern, home of Merthyr RFC, who are determined to prove a lot of people wrong and make their mark in their first season in the Principality Premiership.