Llanelli take their unbeaten record in the Principality Premier Division to Pandy Park where Cross Keys will be hoping to improve on their home record.
After defeating Swansea by a point, they were beaten by visitors Ebbw Vale by just two points but, with only five tries in the bag to date, they may find the Llanelli outfit too strong.
Leading try scorers Neath host Newport at the Gnoll having won their previous three home matches. The Black and Ambers have won all four matches to date and will be full of confidence against the Welsh All Blacks.
If the Scarlets slip, Aberavon are well-placed to take over at the top. They travel to a Bedwas side without a victory after drawing their first match of the season. The Wizards whitewashed Pooler last week and will be looking to hand out more misery at the Bridge Field.
Bridgend are three points ahead of visitors Swansea and a victory for the Ravens should keep them up amongst the leaders.
Both Cardiff and Ebbw Vale have had poor starts to the season but home advantage should see the Arms Park outfit home against the Steelmen. Both sides have only crossed for seven tries so it could all come down to the boot.
Bottom club Llandovery only have one bonus point to show for their efforts this season. They travel to Pontypool Park looking to improve that poor record. The Drovers only have four tries from their five outings and may be another side relying on kicks to keep them in the game.
The final match is at Sardis Road where Pontypridd entertain Glamorgan Wanderers. The Cardiff-based side can usually be relied upon to score points, but Ponty did the double over Wanderers last term.
As the countdown continues for RWC2015, Tournament Chief Executive Debbie Jevans visited the Millennium Stadium to discuss preparations for the eight matches and reveal the positive news that 100,000 tickets for games at the home of Welsh rugby have sold in the last seven days.
Jason Harries is targeting a first win on the World Series circuit this season with Wales. The series returns to action this weekend in Dubai where Harries is part of a team hoping to build from its efforts in round one in October.
Wales skipper Jevon Groves says his side have addressed a few points from Gold Coast and aim to 'hit the ground running' in the next two rounds of the World Series, kicking off with this weekend in Dubai before heading off to South Africa next week.
Wales Sevens manager Steff Thomas is hopeful his side can build from a quarter-final spot in the opening round of the World Series in Australia when his side take part in the forthcoming double header in Dubai and South Africa.