Llanelli take their unbeaten record in the Principality Premier Division to Pandy Park where Cross Keys will be hoping to improve on their home record.
After defeating Swansea by a point, they were beaten by visitors Ebbw Vale by just two points but, with only five tries in the bag to date, they may find the Llanelli outfit too strong.
Leading try scorers Neath host Newport at the Gnoll having won their previous three home matches. The Black and Ambers have won all four matches to date and will be full of confidence against the Welsh All Blacks.
If the Scarlets slip, Aberavon are well-placed to take over at the top. They travel to a Bedwas side without a victory after drawing their first match of the season. The Wizards whitewashed Pooler last week and will be looking to hand out more misery at the Bridge Field.
Bridgend are three points ahead of visitors Swansea and a victory for the Ravens should keep them up amongst the leaders.
Both Cardiff and Ebbw Vale have had poor starts to the season but home advantage should see the Arms Park outfit home against the Steelmen. Both sides have only crossed for seven tries so it could all come down to the boot.
Bottom club Llandovery only have one bonus point to show for their efforts this season. They travel to Pontypool Park looking to improve that poor record. The Drovers only have four tries from their five outings and may be another side relying on kicks to keep them in the game.
The final match is at Sardis Road where Pontypridd entertain Glamorgan Wanderers. The Cardiff-based side can usually be relied upon to score points, but Ponty did the double over Wanderers last term.
Dodgy tattoos, carthorses, Avatar and soft chins are revealed by Wales Sevens players Tom Williams and Sam Cross as they profile the Wales Sevens squad taking part in Hong Kong this weekend in the latest round of the HSBC Sevens World Series.
The youngest member of the Wales Women's squad, Keira Bevan, is hoping to repay the faith shown in her when she starts her first Six Nations game against Italy tomorrow evening in the final round of the championship.
Sevens head coach Gareth Williams is a happy man after drafting in full internationals Rhodri Williams and Adam Warren for the next two rounds of the world series in Hong Kong and Japan, as WRU TV's Graeme Gillespie discovers.
Gemma Rowland has had a 'whirlwind' start to her international career with Wales. Despite losing to France, she is confident Wales Women can bounce back and claim a rare Triple Crown against Ireland on Sunday, as WRU TV's Graeme Gillespie discovers.