Maesteg have not set the division alight since their relegation from the Premier but they will be looking for victory over visitors Cemllynfell Bottom club Dunvant go to Carmarthen Athletic still looking for their first win of the season while Narberth are at LLangennech in a mid-table tussle.
One East leaders Merthyr face a difficult match at Glan yr Afon Park where Blackwood will be looking to carry on their fine early season form. Only six points separate the sides and Blackwood have a game in hand so victory over the Steelmen could open up the top of the table. Bargoed are favourites to win at Newport Saracens who have gained only one losing bonus point to show for their efforts after eight matches, while third-placed Newbridge host the students of UWIC at the Welfare Ground.
Two East leaders Tredegar travel to Cefn Mably to take on unbeaten Llantrisant in that division's top match. Brynmawr will look to close the gap on Tredegar with victory at Struggling Mountain Ash while bottom-placed Treherbert are hoping to get that first win of the season when they entertain Abercynon at Tynewydd Park.
Builth Wells are flying high in Two West with seven wins out of seven and they will be looking to improve their try count at Gorseinon who have lost all six matches to date. Bridgend Athletic's unbeaten record will be put to the test at Waunarlwydd.
It is top against bottom in Three East when Cwmbran travel to Nelson to take on the leaders while Rhymney and Abertillery BG meet in a relegation scrap.
Pontyberem have opened up a ten point gap at the top of Three West thanks to seven straight victories but visitors Laugharne are in third place and promise to be tough opponents.