Xavier Rush has been ruled out of Cardiff Blues' Heineken Cup opener against Calvisano.
The All Black star has failed to recover from knee surgery ahead of the Welsh region's trip to Italy on Saturday.
But Blues coach Dai Young insists talismanic number eight will win his race against time for the crunch Euro tie against Gloucester on October 19.
Young said: "Xavier's injury is a big blow. He is a vital player for us for us but his knee flared-up after the Connacht game.
"We now hope that Xavier will be back for our game with Gloucester at the Millennium Stadium the weekend after next."
The Blues will also be without Wales wing Tom James who has a groin problem but British Lion Gethin Jenkins and Tom Shanklin return.
Blues: Ben Blair; Leigh Halfpenny, Jamie Robinson, Tom Shanklin, Gareth Thomas; Nicky Robinson, Jason Spice; Gethin Jenkins, T Rhys Thomas, Gary Powell, Deiniol Jones, Paul Tito, Maama Molitika, Martyn Williams, Andy Powell.
Replacements: Taufa'ao Filise, Gareth Williams, Scott Morgan, Robin Sowden Taylor, Richie Rees, Ceri Sweeney, Jamie Roberts.
The Wales Women's team headed to Dare Valley Country Park on a team bonding exercise as the entire squad got together for the very first time in preparation for this season's Six Nations championship which kicks off on Saturday with a clash against defending champions Ireland, in Donnybrook.
Wales Head Coach Warren Gatland discusses his team selection for the opening round of the RBS 6 Nations where he leads his side against Ireland, on Sunday. As WRU TV's Luke Brodley discovers, Gatland is fully aware of the challenges the defending champions pose
WRUTV caught up with Wales Women captain Rachel Taylor at the RBS 6 Nations launch and how a good crowd really helps boost the girls performance. Tickets for all three Women's home games at The Gnoll, Neath are available from www.wru.wales/tickets