Xavier Rush has been ruled out of Cardiff Blues' Heineken Cup opener against Calvisano.
The All Black star has failed to recover from knee surgery ahead of the Welsh region's trip to Italy on Saturday.
But Blues coach Dai Young insists talismanic number eight will win his race against time for the crunch Euro tie against Gloucester on October 19.
Young said: "Xavier's injury is a big blow. He is a vital player for us for us but his knee flared-up after the Connacht game.
"We now hope that Xavier will be back for our game with Gloucester at the Millennium Stadium the weekend after next."
The Blues will also be without Wales wing Tom James who has a groin problem but British Lion Gethin Jenkins and Tom Shanklin return.
Blues: Ben Blair; Leigh Halfpenny, Jamie Robinson, Tom Shanklin, Gareth Thomas; Nicky Robinson, Jason Spice; Gethin Jenkins, T Rhys Thomas, Gary Powell, Deiniol Jones, Paul Tito, Maama Molitika, Martyn Williams, Andy Powell.
Replacements: Taufa'ao Filise, Gareth Williams, Scott Morgan, Robin Sowden Taylor, Richie Rees, Ceri Sweeney, Jamie Roberts.
The Webb Ellis Cup visited Lampeter on Monday to recognise the fact that the town is celebrating a major milestone as it is believed the first ever game of rugby played in Wales, was in fact played in Lampeter 150 years ago.
Cardiff Blues U18 Girls will go into Sunday's Gemau Cymru with an extra spring in their step after Welsh internationals Elinor Snowsill and Philippa Tuttiett offered some last minute tips at a training session earlier this week.
Rob Howley and Josh Lewsey addressed more than 250 community club coaches and referees at the first WRU National Community Conference on the weekend. The volunteers benefitted from coaching masterclasses and workshops in a bid to connect all levels of the rugby pathway in Wales.
UEFA has today confirmed the Football Association of Wales (FAW) has been successful in its bid for the Millennium Stadium to host the 2017 UEFA Champions League Final on Saturday 3rd June, 2017 (kick-off: 19.45hrs GMT).