When all the gloss and the hype and the history is stripped away from the game, it remains a hugely important one for a Pontypridd side seeking a first away win in the league this season.
In the build up to the big clash, Ponty coach Paul John remains objective about his team's aspirations of success. "Going away to face a Llanelli team with a 100% success in the league so far is a difficult task" said John "but from our point of view we have nothing to lose. The pressure will be on Llanelli to keep up that record.
"We need to take our home form with us on the bus from Sardis Road, which we haven't done so far this season. If we play to our potential we can achieve a result, and having won and drawn at Stradey last season, the boys know that they have the ability to succeed".
The latest injury victim in the Ponty camp is winger Chris Clayton, with a suspected minor fracture of the wrist. He joins outside half Gareth McCarthy (hamstring) scrum halves Rhys Downes (knee) and Gavin Morris (blood clot) and prop Sam Hobbs (knee) on the sick list.
Ponty welcome back Blues pair, winger Aled Brew and outside half Dai Flanagan, with Matthew Hutchings slotting in at full back and Kristian Baller continuing at scrum half.
Newly recruited tight head prop Pat Palmer makes his debut for Ponty, with Rhys Williams back in at hooker and Rhys Lloyd at blind side flanker.
Pontypridd: 15.Matt Hutchings. 14.Aled Brew. 13.Gavin Dacey. 12.Adam Thomas. 11.Lewis Williams. 10.Dai Flanagan. 9.Kristian Baller; 1.Stuart Williams. 2.Rhys Williams. 3.Pat Palmer. 4.Grant Harrington. 5.Chris Dicomidis. 6.Rhys Lloyd. 7.Wayne O'Connor. 8.Nathan Strong (capt).
Subs: Lawrence Price; Mike Davies; Andrew Jenkins; Ryan Harford; Huw Dowden; Ryan Savage; Geraint Lewis.