Pontypool travel to the Talbot Athletic Ground to face an Aberavon side in third place in the table. Pooler have scored three tries in each of their away fixtures but the Wizards have racked up big victories in their two home matches to date.
Bottom club Llandovery welcome Cardiff to Church Bank still looking for their first points of the season. The Blue and Blacks have lost both away fixtures to date and the home side will be quietly confident they can cause an upset.
The all-Gwent derby at Eugene Cross Park sees Ebbw Vale entertain Newport. The Black and Ambers have started the better this term with three straight victories but the Steelmen are unbeaten at home and that could tilt the result their way.
Swansea entertain Pontypridd with neither side having set the division alight. There was only two points in it last season and it is likely to be just as close this weekend.
In the final match in the division, Cross Keys travel to the Memorial Ground to take on Glamorgan Wanderers. Keys' only victory to date came in a nailbiter at Pandy Park when they held out for a one point victory over Swansea. Wanderers crossed for five tries and a bonus in their only home match to date and will be looking for more of the same.