Llanharan have a tough task to stay at the top of One East when they travel to Virginia Park to take on a Caerphilly side only three points behind them in the table.
The Dairymen could be overtaken by Merthyr, who visit a Penallta outfit still smarting from their heavy defeat last week, or by Newbridge who entertain Rumney.
Bottom-placed clubs Newport Saracens and Ystrad Rhondda meet with the losers left stranded at the foot of the division.
Four clubs are making the pace in One West with leaders Carmarthen Quins hoping to maintain their three point advantage over Tonmawr by beating visitors Felinfoel. The high-scoring Tonmawr outfit, who have played a game less than Quins, play host to Bonymaen while Narberth travel to Maesteg.
The Otters have already bagged 23 tries in their four matches to date but cannot afford to slip as Whitland are unbeaten, only two points behind, and will relish the visit of Carmarthen Athletic who conceded 12 tries on their last away outing.
Treherbert will be looking for points in their trip to Fleur de Lys in Two East. After three matches they have yet to open their account while Fleur already have a victory in the bag. Leaders Llantrisant are at Abergavenny who have lost three times this season so the Black Army should remain in pole position.
Penclawdd have a tough trip to Builth Wells as the Two West leaders have won all four matches this season, but the Cocklemen have won away from home so will not be overawed at meeting the Bulls. There is a bottom-of-the-table clash at Pencoed where the home side entertain Gorseinon with only try count separating the teams.
Rhymney have a tough task in Three East when leaders Gwernyfed visit War Memorial Park. The Brewers have lost both opening matches conceding over 70 points while Gwernyfed are a point ahead at the top of the table. Nelson are handily placed to take advantage of any slip-up against Rhymney and they are home to a New Tredegar side with one bonus point keeping them off the bottom.
Pontyberem have gained maximum points from their first four matches and are already six points ahead of second-placed Cardigan in Three West. They take that record to Lampeter while Cardigan visit bottom club Llanybydder. Aberystwyth are also unbeaten but have played only three games. They entertain a Tumble side that were soundly beaten last time out.
Four clubs are within two points in Four East and it could be all change after the weekend. Leaders Llandaff take on the Squirrels of Rhiwbina in an all-Cardiff clash at Bishop's Field while Monmouth and Machen will hope to keep their unbeaten records against Crumlin and Tredegar Ironsides respectively.
Top plays bottom in Four West where leaders Brynamman play host to Cwmgors. Four clubs are on ten points and two of them, Trimsaran and Tycroes, play each other while Betws visit Tenby and Hendy are at unbeaten Llandeilo.
Abercarn are two points clear at the top of Five East and they entertain Blaenavon while Oakdale, three wins from three outings, put their unbeaten record on the line against Usk.
Swansea Uplands are without a point in Five West and they travel to Milford to play the Mariners who have won their opening three fixtures. Leaders Cefneithen play host to an Aberaeron side that recorded their first victory last weekend.
Wales duo Rhun Williams and Liam Belcher, who makes a welcome return after five months of injury woe, look ahead to next month's World Rugby U20 Championship in Manchester where they will face Ireland, Georgia and New Zealand.
Whenever Bedlinog tackle Penallta a massive fixure is guaranteed but this Sunday there will be even more emphasis placed on the two rivals when they contest the SSE Swalec Plate final at Principality Stadium.
Ahead of their SSE SWALEC Bowl Final clash with Taffs Well at Principality Stadium on Sunday, Burry Port share their #FABXV nomination with WRUTV in the search for Welsh rugby's greatest volunteers. Everyone can get involved by sending nominations via twitter to @WRU_Community using the hashtag #FABXV
Cardiff Blues prop Gethin Jenkins and Ospreys centre Ben John look ahead to the first game at Principality Stadium in Saturday's double header which is promising to be a special occasion for all Welsh fans.
Carmarthen Quins Director of Rugby Ian Jones and committee member Jeff Thomas along with Llandovery chairman Handel Davies look ahead to Sunday's SSE SWALEC Cup showdown where both teams are out to prove 'West is best'
SWALEC ambassador Shane WIlliams is looking forward to Sunday's Finals Day where the Cup, Bowl and Plate offers a great opportunity for players and teams to experience the magic of playing at Principality Stadium
Carmarthen Quins coach Richard Kelly believes it is an exciting time to be part of the Scarlets region as his side take on local rivals Llandovery in the SSE Swalec Cup final on Sunday, as WRU TV's Graeme Gillespie discovers