Llanharan have a tough task to stay at the top of One East when they travel to Virginia Park to take on a Caerphilly side only three points behind them in the table.
The Dairymen could be overtaken by Merthyr, who visit a Penallta outfit still smarting from their heavy defeat last week, or by Newbridge who entertain Rumney.
Bottom-placed clubs Newport Saracens and Ystrad Rhondda meet with the losers left stranded at the foot of the division.
Four clubs are making the pace in One West with leaders Carmarthen Quins hoping to maintain their three point advantage over Tonmawr by beating visitors Felinfoel. The high-scoring Tonmawr outfit, who have played a game less than Quins, play host to Bonymaen while Narberth travel to Maesteg.
The Otters have already bagged 23 tries in their four matches to date but cannot afford to slip as Whitland are unbeaten, only two points behind, and will relish the visit of Carmarthen Athletic who conceded 12 tries on their last away outing.
Treherbert will be looking for points in their trip to Fleur de Lys in Two East. After three matches they have yet to open their account while Fleur already have a victory in the bag. Leaders Llantrisant are at Abergavenny who have lost three times this season so the Black Army should remain in pole position.
Penclawdd have a tough trip to Builth Wells as the Two West leaders have won all four matches this season, but the Cocklemen have won away from home so will not be overawed at meeting the Bulls. There is a bottom-of-the-table clash at Pencoed where the home side entertain Gorseinon with only try count separating the teams.
Rhymney have a tough task in Three East when leaders Gwernyfed visit War Memorial Park. The Brewers have lost both opening matches conceding over 70 points while Gwernyfed are a point ahead at the top of the table. Nelson are handily placed to take advantage of any slip-up against Rhymney and they are home to a New Tredegar side with one bonus point keeping them off the bottom.
Pontyberem have gained maximum points from their first four matches and are already six points ahead of second-placed Cardigan in Three West. They take that record to Lampeter while Cardigan visit bottom club Llanybydder. Aberystwyth are also unbeaten but have played only three games. They entertain a Tumble side that were soundly beaten last time out.
Four clubs are within two points in Four East and it could be all change after the weekend. Leaders Llandaff take on the Squirrels of Rhiwbina in an all-Cardiff clash at Bishop's Field while Monmouth and Machen will hope to keep their unbeaten records against Crumlin and Tredegar Ironsides respectively.
Top plays bottom in Four West where leaders Brynamman play host to Cwmgors. Four clubs are on ten points and two of them, Trimsaran and Tycroes, play each other while Betws visit Tenby and Hendy are at unbeaten Llandeilo.
Abercarn are two points clear at the top of Five East and they entertain Blaenavon while Oakdale, three wins from three outings, put their unbeaten record on the line against Usk.
Swansea Uplands are without a point in Five West and they travel to Milford to play the Mariners who have won their opening three fixtures. Leaders Cefneithen play host to an Aberaeron side that recorded their first victory last weekend.
Wales Head Coach Rob Howley talks to WRU TV's Sebastian Barrett about the 36-man squad he has just named for the forthcoming Under Armour series, which includes two uncapped players, Ospreys duo Sam Davies and Rory Thornton.
Head coach Rowland Phillips is deligthed he can now call BT Sport Cardiff Arms Park home for his Wales Women's side, who launch their international season next month with games against Scotland and UK Armed Forces in the heart of the capital city.
Wales Sevens star Sam Cross has put his home town club of Brynmawr on the map after winning a silver medal at the Rio Olympics with Team GB. His club have now honoured him by naming their players bar after him, as WRU TV discovered at the official launch, recently.
One of the newest members of the Principality Premiership, Bargoed admit it's proving to be a steep learning curve at the highest level, but are determined to become a force to be reckoned with. WRU TV visited the club last weekend when they took on Llanelli.
Table-topping Aberavon travel to north Wales to tackle RGC 1404 as both teams defend unbeaten starts to the season in the Principality Premiership. WRU TV's Graeme Gillespie visited the Wizards to see how their preparations were going for the game of the weekend.
The Half a Game initiative is currently sweeping across Wales and proving a major success. The scheme aims to give every young player at least half a game every weekend. WRU TV recently visited a festival in Narberth where clubs have fully embraced the initiative.
Both Bargoed and Swansea were seeking their first win of the Principality Premiership season this afternoon. It proved a fruitful day for the hosts - not only did they win, but Bargoed claimed a try bonus point.
Cardiff managed to keep their unbeaten record at home intact, but only just as Bridgend made them work extremely hard before the Blue and Blacks secured a hard fought Principality Premiership win at the BT Sport Arms Park last night.
Former Wales back row Andy Powell gives a guided tour of The Wern, home of Merthyr RFC, who are determined to prove a lot of people wrong and make their mark in their first season in the Principality Premiership.
Wales Sevens head coach Gareth Williams looks back on the Rio Sevens success where he helped GB win silver. He believes the successful campaign is a huge boost to his Welsh squad as they prepare for another World Series, as WRU TV's Graeme Gillespie discovers