Llanharan have a tough task to stay at the top of One East when they travel to Virginia Park to take on a Caerphilly side only three points behind them in the table.
The Dairymen could be overtaken by Merthyr, who visit a Penallta outfit still smarting from their heavy defeat last week, or by Newbridge who entertain Rumney.
Bottom-placed clubs Newport Saracens and Ystrad Rhondda meet with the losers left stranded at the foot of the division.
Four clubs are making the pace in One West with leaders Carmarthen Quins hoping to maintain their three point advantage over Tonmawr by beating visitors Felinfoel. The high-scoring Tonmawr outfit, who have played a game less than Quins, play host to Bonymaen while Narberth travel to Maesteg.
The Otters have already bagged 23 tries in their four matches to date but cannot afford to slip as Whitland are unbeaten, only two points behind, and will relish the visit of Carmarthen Athletic who conceded 12 tries on their last away outing.
Treherbert will be looking for points in their trip to Fleur de Lys in Two East. After three matches they have yet to open their account while Fleur already have a victory in the bag. Leaders Llantrisant are at Abergavenny who have lost three times this season so the Black Army should remain in pole position.
Penclawdd have a tough trip to Builth Wells as the Two West leaders have won all four matches this season, but the Cocklemen have won away from home so will not be overawed at meeting the Bulls. There is a bottom-of-the-table clash at Pencoed where the home side entertain Gorseinon with only try count separating the teams.
Rhymney have a tough task in Three East when leaders Gwernyfed visit War Memorial Park. The Brewers have lost both opening matches conceding over 70 points while Gwernyfed are a point ahead at the top of the table. Nelson are handily placed to take advantage of any slip-up against Rhymney and they are home to a New Tredegar side with one bonus point keeping them off the bottom.
Pontyberem have gained maximum points from their first four matches and are already six points ahead of second-placed Cardigan in Three West. They take that record to Lampeter while Cardigan visit bottom club Llanybydder. Aberystwyth are also unbeaten but have played only three games. They entertain a Tumble side that were soundly beaten last time out.
Four clubs are within two points in Four East and it could be all change after the weekend. Leaders Llandaff take on the Squirrels of Rhiwbina in an all-Cardiff clash at Bishop's Field while Monmouth and Machen will hope to keep their unbeaten records against Crumlin and Tredegar Ironsides respectively.
Top plays bottom in Four West where leaders Brynamman play host to Cwmgors. Four clubs are on ten points and two of them, Trimsaran and Tycroes, play each other while Betws visit Tenby and Hendy are at unbeaten Llandeilo.
Abercarn are two points clear at the top of Five East and they entertain Blaenavon while Oakdale, three wins from three outings, put their unbeaten record on the line against Usk.
Swansea Uplands are without a point in Five West and they travel to Milford to play the Mariners who have won their opening three fixtures. Leaders Cefneithen play host to an Aberaeron side that recorded their first victory last weekend.
Porthcawl recently received a WRU facilities grant and funding from Natwest RugbyForce in order to give their changing rooms a facelift. This came after receiving £10,000 in a WRU facilities grant last year to tarmac their car park. The improvements have already helped to make the club more accessible, not only for their own members and players but for the whole community.
The Welsh Rugby Union has launched a new, accredited Safeguarding and Protecting Children course - funded by the WRU and delivered in partnership with Sport Wales and the NSPCC - fo rugby club volunteers around Wales.
The SWALEC semi-final draws threw up some mouth-watering clashes in the Cup, Plate and Bowl as the 12 teams aim for the Millennium Stadium Finals Day. All the semi-finals are to be played on the weekend of April 12.
Welsh whistler Rhys Thomas continues to scale the heights of the game as he prepares to be an official in this weekend's Hong Kong Sevens tournament, undoubtedly the showpiece event on the World Series calendar.
Wales International Ian Evans and Wales and Lions legend Scott Quinnell swapped rugby balls for paint pots at Tonna during the RBS 6 Nations. They surprised club players with a special clubhouse makeover to launch NatWest RugbyForce 2014 - a programme developed in partnership with the WRU to make rugby clubs stronger businesses by improving and renovating their facilities with the support of volunteers and the local community.
Fresh from claiming the Bowl honours in Tokyo last Sunday, the Wales Sevens squad have settled into their routine as they prepare for this weekend's Hong Kong tournament where Iolo Evans is aiming high, as WRU TV's Graeme Gillespie discovers.
The Welsh Rugby Union has recently teamed up with Prostate Cymru to help the charity launch its latest campaign to raise awareness of the disease. Members of the Wales squad helped produce a short video and promotional material for the campaign titled 'The Best Defence - is to know the FACTS'.