David Young has made six changes for this weekend's crunch EDF Energy Cup match against the Leicester Tigers at the Arms Park.
In the backs, Jamie Roberts and Richard Mustoe, return to the starting line up. While in the back row, Robin Sowden Taylor comes in at Openside, with Martyn Williams moving down to the bench.
There is also a new front row with Taufa'ao Filise, Gareth Williams and John Yapp all starting.
Meanwhile, Seru Rabeni will make his first start of the season for Leicester Tigers
The Fijian, who returned from suspension to appear as a second-half replacement in last weekend's nine-try win over Benetton Treviso in the Heineken Cup, is named on the wing by head coach Heyneke Meyer.
Johne Murphy, who scored a hat-trick of tries in Italy last Saturday, moves to full-back, while Derick Hougaard returns at fly-half and Toby Flood moves to inside centre.
George Chuter and Boris Stankovich return to the front row and Richard Blaze is named in the second row as Ben Kay moves to the replacements' bench.
"We made a good start to the competition with the away win against Bath," said Meyer. "Now we have another tough game."
The Cardiff Blues will be aiming to send away the Leicester Tigers in this crucial EDF Energy Cup game and tickets for the match are still available.
Junor tickets priced at just £5. Tickets for adults are priced at £16 for terrace or family stand and £20 for grandstand. Tickets can be purchased by calling 029 2030 2030 or online at www.cardiffblues.com/tickets
Cardiff Blues: Ben Blair; Leigh Halfpenny, Jamie Robinson, Jamie Roberts, Richard Mustoe; Nick Robinson, Jason Spice; John Yapp, Gareth Williams, Taufa'ao Filise, Deiniol Jones, Paul Tito (capt), Maama Molitika, Robin Sowden Taylor, Andy Powell.
Replacements: Gary Powell, T Rhys Thomas, Scott Morgan, Martyn Williams, Richie Rees, Ceri Sweeney, Tom Shanklin.
Leicester 15 Johne Murphy 14 Seru Rabeni 13 Danny Hipkiss 12 Toby Flood 11 Matt Smith 10 Derick Hougaard 9 Harry Ellis 1 Boris Stankovich2 George Chuter 3 Julian White 4 Richard Blaze 5 Marco Wentzel 6 Martin Corry (captain) 7 Tom Croft 8 Jordan Crane
Replacements 16 Benjamin Kayser 17 Dan Cole 18 Ben Kay 19 Brett Deacon 20 Julien Dupuy 21 Ayoola Erinle 22 Tom Varndell
The Wales U18 squad spent an emotional day in the drug-riddled townnship of Hout Bay. Hout Bay Warriors President Fred Johannes said the visit was 'the talk of the town' and will dream about the day everyday for the rest of his life.
RGC 1404's new head coach Mark Jones is hoping to build 'something special' in north Wales and is already looking forward to the development region participating in the Principality Premiership for the very first time.
A joint venture between the WRU and Admiral saw hundreds of children enjoy the Admiral Festival of Rugby held at the National Centre of Excellence at the weekend where Welsh internationals Sam Warburton, Scott Williams and Rob Evans were in attendance.
Wll Jones leads Wales U18s into battle this afternoon against Italy where the Welsh side will be seeking to bounce back from their narrow defeat to SA Schools in their opening clash of the U19 International Series
All four regions attended a successful training camp staged last weekend at the WRU National Centre of Excellence. It was a chance for new Wales Women's head coach Rowland Phillips to deliver his key messages to players and coaches as he prepares for the new season.
Wales U18 Team Manager Gethin Watts believes the next couple of weeks will be 'extremely beneficial' to the future of Welsh rugby as his side prepare to take part in the Under 19 International Series being staged in South Africa.
The WRU is searching for 12 new rugby development apprentices following a successful first year of its WRU Coach Core programme. Craig Duncan and Jess Hancock have flourished in the first year of the programme which has given them a real direction in their lives.
The WRU signed TV comedian Rhod Gilbert up to a 'Coaching Children Level 1' course before letting him loose on an U8s side at Whitland Junior Borderers - we went behind the scenes to film the making of 'Rhod Gilbert's Work Experience' see the results here.
Llandovery are aiming to make it three titles in a row in this year's Foster's National 7s being held at BT Sport Cardiff Arms Park on Sunday 28 August. Drovers assistant coach Simon Davies and Lee Rees assess their sides chances
A pioneering strength and conditioning programme has been delivered to more than 8000 boys and girls at hub schools throughout Wales this season, helping to develop stronger, more flexible athletes for rugby and other sports.
The Singha Premiership Rugby 7s Series returns to the BT Sport Cardiff Arms Park on July 22nd when all four Welsh regions go head to head. Scarlets skills coach Dai Flanagan and Blues Elite Performance Pathway Manager Richard Hodges along with current Welsh squad members were at the launch of this season's event