There is a relegation battle at Bedwas where Cross Keys are the visitors. Both clubs need points to steer themselves away from the foot of the table and Bridge Field may not be for the faint-hearted but Keys are in form and may just do enough for victory.
Despite having lost three times already this season Aberavon are in third spot. With four home victories to date they will be ready for the challenge from Bridgend and should be strong enough to cement their position.
Cardiff and Glamorgan Wanderers are bracketed together in mid-table on 19 points. Wanderers have managed just the one away victory this term but they beat Cardiff at the Arms Park last season and will be all out to repeat that result so it could be a close call.
Pontypool have had a difficult start to life back in the top flight and they host Pontypridd looking for the victory that will move them away from the drop zone.
In the final match Ebbw Vale travel to Swansea with the Steelmen fully eight points better off than the All Whites. Vale have won three out four away games this season and could well come up with another victory.