The top two teams in the Principality Premiership meet at Rodney Parade where Newport entertain Llanelli. The Black and Ambers are just three points adrift behind the Scarlets and victory would see them top of the table.
Llandovery have a tough task trying to follow last week's first win of the season with another four pointer. They meet fifth-placed Neath at their Church Bank ground but will be confident of causing an upset because the Welsh All Blacks have been beaten on their last two league outings.
There is a relegation battle at Bedwas where Cross Keys are the visitors. Both clubs need points to steer themselves away from the foot of the table and Bridge Field may not be for the faint-hearted but Keys are in form and may just do enough for victory.
Despite having lost three times already this season Aberavon are in third spot. With four home victories to date they will be ready for the challenge from Bridgend and should be strong enough to cement their position.
Cardiff and Glamorgan Wanderers are bracketed together in mid-table on 19 points. Wanderers have managed just the one away victory this term but they beat Cardiff at the Arms Park last season and will be all out to repeat that result so it could be a close call.
Pontypool have had a difficult start to life back in the top flight and they host Pontypridd looking for the victory that will move them away from the drop zone.
In the final match Ebbw Vale travel to Swansea with the Steelmen fully eight points better off than the All Whites. Vale have won three out four away games this season and could well come up with another victory.
Carmarthen Quins are holding an exhibition to commemorate club players who fought in World War I. All welcome to the clubhouse on Friday afternoon to learn more about local history, or share any family anecdotes or artifacts.
Defence coach Shaun Edwards believes Saturday's clash against England - the 'form team in world rugby' - poses a huge challenge for his side but he is confident, with Wales beginning to show the defensive qualities displayed in the last two World Cups,