The top two teams in the Principality Premiership meet at Rodney Parade where Newport entertain Llanelli. The Black and Ambers are just three points adrift behind the Scarlets and victory would see them top of the table.
Llandovery have a tough task trying to follow last week's first win of the season with another four pointer. They meet fifth-placed Neath at their Church Bank ground but will be confident of causing an upset because the Welsh All Blacks have been beaten on their last two league outings.
There is a relegation battle at Bedwas where Cross Keys are the visitors. Both clubs need points to steer themselves away from the foot of the table and Bridge Field may not be for the faint-hearted but Keys are in form and may just do enough for victory.
Despite having lost three times already this season Aberavon are in third spot. With four home victories to date they will be ready for the challenge from Bridgend and should be strong enough to cement their position.
Cardiff and Glamorgan Wanderers are bracketed together in mid-table on 19 points. Wanderers have managed just the one away victory this term but they beat Cardiff at the Arms Park last season and will be all out to repeat that result so it could be a close call.
Pontypool have had a difficult start to life back in the top flight and they host Pontypridd looking for the victory that will move them away from the drop zone.
In the final match Ebbw Vale travel to Swansea with the Steelmen fully eight points better off than the All Whites. Vale have won three out four away games this season and could well come up with another victory.
Sam Cross and Luke Treharne have been named as co-captains of the Wales Sevens side as head coach Gareth Williams names his 12-man squad to play in the first leg of the HSBC World Series in Dubai next weekend.
Bedwas head coach Steve Law and players Nicky Griffiths and Alun Rees extol the virtues of the close knit club as they prepare to host third place RGC 1404 - who are one place head of them on the Principality Premiership points table - on Saturday.
Many of the Wales squad have said Diolch (thank you) to someone who played an important part in their early playing days by nominating them to be invited to the Wales v South Africa match. One person, Gowerton Comprehensive geography teacher Mr Dean Mason was nominated by two of his former pupils, Dan Biggar and Sam Davies.
The second WRU disability rugby pilot has been delivered, this time in Caerphilly schools, culminating in a festival at the Caerphilly Centre of Sporting Excellence, Ystrad Mynach tomorrow. Plans are in place to set up a Disability Rugby Club in Newbridge to provide long-term playing opportunities.
WRU TV: Hear from inside the Wales camp as Neil Jenkins discusses this weekend's clash with South Africa and how the squad are looking to put in a strong performance to round of the 2016 Under Armour Series