Coach Richard Hodges introduces another back row with starts for Jevon Groves (Blues academy), Ben White (Blues) and last season's player of the year Richard Thomas.
In the backs there is only one change where Dafydd Hewitt returns to the centre instead of Gareth Morris, after picking up an injury in the Aberavon game.
Outside half Scott Sneddon who has had an excellent start to the season will no doubt be keen to close the points gap on Bridgend's Gareth David who leads the Premiership points table. Scott is currently 3rd with 69 points.
Glamorgan Wanderers: 15. James Loxton 14. Steve Cullen 13. Robin Lock 12. Dafydd Hewitt 11. Jason Pocock 10. Scott Sneddon 9. Luke Evans: 1. Nathan Trevett 2. Ryan Price 3. Scott Andrews 4. Nick Kelly (capt) 5. Tom Evans 6. Jevon Groves 7. Ben White 8. Richard Thomas
Replacements: 16. Mark Sheppard 17. Rhys Gill 18. Mark O'Leary 19. Alex Luff 20. Alistair McDonald 21. Glen Holloway 22. Luke Fear