Ystradgynlais No 8 David Love indulged in a bit of student bashing as he scored five of their eight tries in a 50-24 win at Swansea University.
The day's big winners were Llandudno, who humbled a depleted Burry Port 95-5.
Llandudno's 15 tries included seven from there centre pairing of Lloyd Owen, who ran in four tries, and David Davies who scored a hat-trick.
It was a family affair for Cardigan, as brothers Guto and Iestyn Crompton were both on the scoresheet as the home side beat Pwllheli 22-21.
Guto crossed twice whilst Iestyn, as well as converting both tries, kicked the winning penalty five minutes from the end.
Penygroes saw the try count rule work in their favour as they advanced after drawing 14-14 with Aberavon Green Stars.
Billy Lewis and Darren Price crossed in either half for Penygroes, meaning they won the game 2-1 on tries despite a Green Stars comeback.
Birchgrove of squeezed through to the third round after a narrowly beating Amman United 25-21.
Lee Mainwaring scored 20 of the home sides 25 points, in the form of 2 tries, 2 penalties and 2 conversions.
Hendy won a Llanelli derby at Furnace 19-15. Emyr Harris went over for their only try which was converted by Lee Evans, who also kicked four penalties.
Tredegar are the team on everyone's lips so far in the Swalec Cup after racking up 146 points and 22 tries in the opening two rounds.
Their 56-10 victory against Cwmgwrach came after their club record 90-0 win against Pontllanfraith in the first round. Greg Jones grabbed a 21 point haul from a try and eight conversions while Jamie Henthorn and Chris James each claimed two tries a piece.
Division Five South-East outfit Cowbridge pulled of the shock of the second round, defeating Mumbles 16-10. Despite the three division gap between the clubs, two second half penalties from Ed Lakin sealed an unlikely victory after the sides had gone into the break at 10-10.
Talywain stunned a Nantymoel side placed two divisions above them in a 27-5 triumph with Gareth Needs scoring two of his side's four tries at Emlyn Park. In other second round upsets, Division Four Monmouth overcame Seven Sisters of Division Three 34-17, and Aberavon Quins beat Abergavenny 5-3 thanks to an early try from left-wing Adam Dawe.
Bedlinog were the big scorers of the second round after they scored 11 tries in a 71-0 mauling of Llanidloes. Thomas Cox and Lee Harrison each grabbed a hat-trick of tries for The Foxes.
When the Wales squad were asked to nominate individuals who played a big part in their early playing days, Wales and Dragons full back and wing Hallam Amos thought of his former Monmouth School rugby coach John Bevan.
Sam Cross and Luke Treharne have been named as co-captains of the Wales Sevens side as head coach Gareth Williams names his 12-man squad to play in the first leg of the HSBC World Series in Dubai next weekend.
Bedwas head coach Steve Law and players Nicky Griffiths and Alun Rees extol the virtues of the close knit club as they prepare to host third place RGC 1404 - who are one place head of them on the Principality Premiership points table - on Saturday.
Many of the Wales squad have said Diolch (thank you) to someone who played an important part in their early playing days by nominating them to be invited to the Wales v South Africa match. One person, Gowerton Comprehensive geography teacher Mr Dean Mason was nominated by two of his former pupils, Dan Biggar and Sam Davies.
The second WRU disability rugby pilot has been delivered, this time in Caerphilly schools, culminating in a festival at the Caerphilly Centre of Sporting Excellence, Ystrad Mynach tomorrow. Plans are in place to set up a Disability Rugby Club in Newbridge to provide long-term playing opportunities.
WRU TV: Hear from inside the Wales camp as Neil Jenkins discusses this weekend's clash with South Africa and how the squad are looking to put in a strong performance to round of the 2016 Under Armour Series