After running in 13 tries last weekend, Aberystwyth failed to register a single effort in the 11-3 defeat to Division Three West league leaders Pontyberem.
Tondu top Division Three south-west after a bonus-point 32-10 win over Maesteg Quins while Aberavon Quins kept up the pressure with a 53-12 success over Seven Sisters.
Llandeilo took over from Brynamman at the top of Division Four West after cruising to a 37-0 victory at Cwmgors.
Brynamman's good start to the season came to a halt with a narrow 17-16 loss to Pembroke Dock Quins.
There was a shock 15-11 home defeat for Vardre in Division Four South West against Pontycymmer.
New leaders Resolven took full advantage and made it five wins from five with a 30-24 success on the road at Bryncoch.
Penlan remain top of the pile in Division Five West after running in 13 times in the 87-16 hammering of Llangadog while Nantgaredig also bagged a bonus-point win over Aberavon Naval.