Despite Gavin Henson's absence, Sean Holley (thumb) has still fielded a strong side for Sunday's showdown.
Despite a lengthy injury list, Ospreys coach Sean Holley has still fielded a side containing 14 internationals for the Heineken Cup showdown against Leicester Tigers at Welford Road, on Sunday.
One notable omission is Gavin Henson who has been banned for two games by the management for a 'rugby related internal disciplinary decision.'
The Tigers have an impressive pedigree in the tournament having won it twice and being runners-up on another two occasions and Holley is under no illusions as to the size of the task which awaits his star-studded side.
"Everybody within the Ospreys camp is looking forward to renewing what has become a healthy rivalry with Leicester. We have the utmost respect for their playing and coaching staff, and for what the club has achieved over the years, and in particular in the Heineken Cup," he said.
"They've made a good start to the current season and are playing some great rugby under their new coach Heyneke Meyer. We know that we can expect a real test on Sunday. We see Welford Road as being a great place to start this year's campaign, there will be a great atmosphere there as always.
"We have a very tight unit at the Ospreys, matches such as this one are as much about the 22 selected as the starting line-up itself, spirits are high and we intend to be extremely competitive on Sunday. We are particularly proud to be able to name 18 Welsh players in our 22, which is further evidence of the excellent work that we are doing here at the Ospreys to develop the best local talent."
Holley also conceded some difficult decisions had to be made when it came to selecting the side to open the cup campaign.
"Our players are excited about the prospect of playing in this year's Heineken Cup, they want to get off to a good start in Leicester and it has been a very difficult selection process this week with so many players in numerous positions challenging for a starting place this Sunday. A lot is at stake, as there always is in the first Pool match in this competition, and we will need to be both focused and determined against a quality team if we are to achieve our aim."
Ospreys: 15 Lee Byrne, 14 Nikki Walker, 13 Tommy Bowe, 12 Andrew Bishop, 11 Shane Williams, 10 James Hook, 9 Rhodri Wells.
8 Ryan Jones (c), 7 Marty Holah, 6 Jonathan Thomas, 5 Ian Evans, 4 Alun-wyn Jones, 3 Adam Jones, 2 Richard Hibbard, 1 Paul James.
Replacements: 16 Huw Bennett, 17 Duncan Jones, 18 Ian Gough, 19 Filo Tiatia, 20 Tom Smith, 21 Rhys Webb, 22 Daniel Biggar.
Leicester Tigers: 15 Geordan Murphy, 14 Johne Murphy, 13 Dan Hipkiss, 12 Aaron Mauger, 11 Matt Smith, 10 Toby Flood, 9 Harry Ellis.
1 Marcos Ayerza, 2 Benjamin Kayser, 3 Julian White, 4 Martin Corry (capt), 5 Ben Kay, 6 Tom Croft, 7 Ben Woods, 8 Jordan Crane.
Replacements: 16 George Chuter, 17 Dan Cole, 18 Richard Blaze, 19 Marco Wentzel, 20 Julien Dupuy, 21 Derick Hougaard, 22 Alesana Tuilagi.
Wales head coach Rob Howley explains his decision to change the captaincy of the national side with Ospreys second row Alun Wyn Jones taking over from Sam Warburton for the forthcoming RBS 6 Nations. Howley is hoping his decision will allow Warburton to rediscover his 'mojo'.
How do you follow a dancing hippopotamus - the Ospreys wheelchair rugby team has just the 'oneness' to do it say the BBC! For a decade the sight of a herd of hippos synchronised swimming around their own private blue lagoon, has lit up our television screens at regular intervals between favourite BBC One shows. But now the nation's most watched channel has relinquished its famous amphibious mammals in favour of a new show-reel which includes the Ospreys wheelchair rugby team.
Head coach Rowland Phillips and key front rower Carys Phillips look ahead to games against Spain and Ireland as Wales Women ramp up their preparations for the forthcoming Six Nations. The two warm-up games are a 'massive opportunity to refine the squad' according to the Welsh camp.
Martyn Phillips has discussed details of the newly published 'Strategy for Welsh Rugby' which puts in black and white terms the plans and direction of the governing body of the national sport in Wales for the next decade.
WRU chief executive Martyn Phillips has urged Welsh rugby fans to follow in the footsteps of their soccer counterparts at last summer's Euro Championship by backing their team to the hilt in the upcoming RBS 6 Nations campaign.
Chief executive Martyn Phillips has highlighted the plans for Wales to become a breeding ground for national and elite club rugby coaches, which are contained in the WRU's 10-year 'Strategy for Welsh Rugby'.
Andrew Coombs is enjoying his new role as Nelson forwards coach. The former Dragons and Wales lock has big ambitions to become a professional coach but feels it's important to learn the ropes in grassroots rugby and where better than his home club Nelson, with friends and family close to hand.
Students at Brynllywarch Hall School, near Newtown, have transformed their own lives, and are now having a positive impact on others through rugby. The sport has had a life-changing effect on the well-being of the students who are now delivering rugby sessions to local primary schools and playing for a new mixed ability side
Wales reached their first semi-final since 2013 in the opening round of this season's HSBC World Rugby Sevens Series in Dubai. WRU TV's Graeme Gillespie recaps on what proved to be an eventful tournament
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Beating Merthyr has boosted Carmarthen Quins hopes of reaching a top eight spot in the Principality Premiership. Quins captain Haydn Pugh is delighted with his team's progress and is determined that everyone from the Under 6s through to the senior team, enjoys the ride.
When the Wales squad were asked to nominate individuals who played a big part in their early playing days, Wales and Dragons full back and wing Hallam Amos thought of his former Monmouth School rugby coach John Bevan.
Sam Cross and Luke Treharne have been named as co-captains of the Wales Sevens side as head coach Gareth Williams names his 12-man squad to play in the first leg of the HSBC World Series in Dubai next weekend.
Bedwas head coach Steve Law and players Nicky Griffiths and Alun Rees extol the virtues of the close knit club as they prepare to host third place RGC 1404 - who are one place head of them on the Principality Premiership points table - on Saturday.