Despite Gavin Henson's absence, Sean Holley (thumb) has still fielded a strong side for Sunday's showdown.
Despite a lengthy injury list, Ospreys coach Sean Holley has still fielded a side containing 14 internationals for the Heineken Cup showdown against Leicester Tigers at Welford Road, on Sunday.
One notable omission is Gavin Henson who has been banned for two games by the management for a 'rugby related internal disciplinary decision.'
The Tigers have an impressive pedigree in the tournament having won it twice and being runners-up on another two occasions and Holley is under no illusions as to the size of the task which awaits his star-studded side.
"Everybody within the Ospreys camp is looking forward to renewing what has become a healthy rivalry with Leicester. We have the utmost respect for their playing and coaching staff, and for what the club has achieved over the years, and in particular in the Heineken Cup," he said.
"They've made a good start to the current season and are playing some great rugby under their new coach Heyneke Meyer. We know that we can expect a real test on Sunday. We see Welford Road as being a great place to start this year's campaign, there will be a great atmosphere there as always.
"We have a very tight unit at the Ospreys, matches such as this one are as much about the 22 selected as the starting line-up itself, spirits are high and we intend to be extremely competitive on Sunday. We are particularly proud to be able to name 18 Welsh players in our 22, which is further evidence of the excellent work that we are doing here at the Ospreys to develop the best local talent."
Holley also conceded some difficult decisions had to be made when it came to selecting the side to open the cup campaign.
"Our players are excited about the prospect of playing in this year's Heineken Cup, they want to get off to a good start in Leicester and it has been a very difficult selection process this week with so many players in numerous positions challenging for a starting place this Sunday. A lot is at stake, as there always is in the first Pool match in this competition, and we will need to be both focused and determined against a quality team if we are to achieve our aim."
Ospreys: 15 Lee Byrne, 14 Nikki Walker, 13 Tommy Bowe, 12 Andrew Bishop, 11 Shane Williams, 10 James Hook, 9 Rhodri Wells.
8 Ryan Jones (c), 7 Marty Holah, 6 Jonathan Thomas, 5 Ian Evans, 4 Alun-wyn Jones, 3 Adam Jones, 2 Richard Hibbard, 1 Paul James.
Replacements: 16 Huw Bennett, 17 Duncan Jones, 18 Ian Gough, 19 Filo Tiatia, 20 Tom Smith, 21 Rhys Webb, 22 Daniel Biggar.
Leicester Tigers: 15 Geordan Murphy, 14 Johne Murphy, 13 Dan Hipkiss, 12 Aaron Mauger, 11 Matt Smith, 10 Toby Flood, 9 Harry Ellis.
1 Marcos Ayerza, 2 Benjamin Kayser, 3 Julian White, 4 Martin Corry (capt), 5 Ben Kay, 6 Tom Croft, 7 Ben Woods, 8 Jordan Crane.
Replacements: 16 George Chuter, 17 Dan Cole, 18 Richard Blaze, 19 Marco Wentzel, 20 Julien Dupuy, 21 Derick Hougaard, 22 Alesana Tuilagi.
Principality Stadium will host the UEFA Champions League Final in six weeks' time. WRU chairman Gareth Davies, Football Association of Wales chief executive Jonathan Ford and Ambassador Ian Rush joined young sports fans at the trophy arrival at the venue to celebrate the magnitude of the event on Saturday 3rd June (kick-off 19.45).
British and Irish Lions captain Sam Warburton is looking forward to bringing together players from Ireland, Scotland, England and Wales for the biggest challenge of their careers - a series against world champions, New Zealand.
For the fifth year running, Wales referee Nigel Owens will be in charge of proceedings at Judgement Day V at Principality Stadium. It promises to be 'extra special' for the Wales' favourite ref, as he will be making his 150th appearance in the league.
There will be no shortage of inside knowledge from Bowl Finalists Caerphilly and Amman United when they face each other on Sunday at National Finals Day. Caerphilly hooker Rhys Cleverly knows the Principality Stadium pitch better than most as a matchday groundsman, while Amman United can look to Wales' record try scorer Shane Williams for some helpful advice.
Two hundred and 40 teams competed in the inaugural Urdd WRU 7s held at Pencoed last week with Welsh internationals Steff Andrews and Jasmine Joyce impressed with the talent on display, as was Urdd chief executive, Sioned Hughes.
The countdown is on for Judgement Day V as tickets for the big day at Principality Stadium soar through the 50,000 mark. Players and coaches alike are bursting at the seams to play in the double header with Dragons coach Kingsley Jones claiming there is a 'real buzz' about the event.
WRU TV went behind the scenes when the four regions got together to test their skill set for the BBC's Scrum V Live rugby show, at the WRU National Centre of Excellene in the build up to Judgement Day V. Blues' Matthew Morgan was one of the stars of the show while the Dragons' Cory Hill proved a surprise package...the full set of results will be revealed on tv screens on matchday
Wales assistant coach Richie Pugh is confident his side can cause a few headaches in the Hong Kong Sevens this weekend. In a tough group, Wales kick off their campaign against New Zealand on Friday before playing Japan and Fiji, who are chasing their third consecutive Hong Kong title, on Saturday.
Bedwas had to overcome a stubborn Carmarthen Quins side before winning the Foster's Challenge Cup final in Bridgend with a 23-18 victory. Bedwas captain Nicky Griffiths pays tribute to his side who have claimed the club's first piece of silverware in the modern era.
Team coach Brett Davey is aiming to keep his unbeaten run in cup finals at Principality Stadium intact when his side take on Amman United in the WRU Bowl final, after he guided Caerphilly to a 20-14 win against Cilfynydd in the semi-finals.
Penallta are hoping to go one step further than last season when falling to Bedlinog in the WRU Plate Final. After a titanic struggle against Nant Conwy, they have given themselves a great chance, after a hard fought 18-13 semi-final victory.