And the Wallaby star is desperate to bring down the 6ft 4in, 18st giant to give Stradey Park the perfect European farewell on Saturday.
Lyons, 28, said: "I've seen Nick a lot over the last year especially in the World Cup quarter-final when England beat us.
"I had broke my leg and was watching on from the sidelines and I can remember he had a great game that day.
"He will definitely be someone I will keep my eye on. He does a lot of the ugly stuff and hard graft but is still a quality ball carrier."
Easter starts on the bench for Quins while Lyons makes his European debut in Llanelli in the final Euro tie before the Welsh region quit their 129-year-old home for the £23million Parc y Scarlets in November.
And the 43-cap forward, who has played in two World Cups, admits there is one glaring omission left on his CV.
Lyons said: "I didn't come over here for a holiday and I'm really excited about playing in the Heineken Cup.
"I've always wanted to play on one game and it's one of the last things for me to tick off. I've watched it on TV in Australia and noticed the intensity and support.
"It will be a big occasion at Stradey Park. It's a great rugby venue and you can not escape the history. Hopefully the final European game will spark our best form because we want to put on a great display that this place deserves."