The Ospreys have been boosted by the surprise return of Nikki Walker and Jamie Nutbrown to their squad for the EDF Energy Cup tie with Worcester this Sunday.
Scotland wing Walker suffered a broken hand in the Heineken Cup loss at Leicester two weeks ago while Nutbrown also returns following a foot injury.
Gavin Henson is expected to start after his disciplinary problems and after only playing one match this season, will be desperate to get some game time ahead of the Invesco Perpetual Autum Series, having only played one full match this season.
Duncan Jones said: "We had a tough game against Harlequins and the win was all important. We do not want to let go off this trophy easily as champions.
"We recorded a good win away to Worcester last season but we will not be complacent. They are a totally different side, we understand it will be physical but we're up for the challenge and looking for a win."
Ospreys (from): Backs: Lee Byrne, Nikki Walker, Tommy Bowe, Shane Williams, Andrew Bishop, Gavin Henson, Ashley Beck, Dan Biggar, James Hook, Rhys Webb, Jamie Nutbrown. Forwards: Duncan Jones, Adam Jones, Andrew Millward, Richard Hibbard, Huw Bennett, Lyndon Bateman, Alun Wyn Jones, Ian Gough, Ryan Jones, Tom Smith, Filo Tiatia, Steve Tandy.
Ahead of their SSE SWALEC Bowl Final clash with Taffs Well at Principality Stadium on Sunday, Burry Port share their #FABXV nomination with WRUTV in the search for Welsh rugby's greatest volunteers. Everyone can get involved by sending nominations via twitter to @WRU_Community using the hashtag #FABXV
Cardiff Blues prop Gethin Jenkins and Ospreys centre Ben John look ahead to the first game at Principality Stadium in Saturday's double header which is promising to be a special occasion for all Welsh fans.
Carmarthen Quins Director of Rugby Ian Jones and committee member Jeff Thomas along with Llandovery chairman Handel Davies look ahead to Sunday's SSE SWALEC Cup showdown where both teams are out to prove 'West is best'
SWALEC ambassador Shane WIlliams is looking forward to Sunday's Finals Day where the Cup, Bowl and Plate offers a great opportunity for players and teams to experience the magic of playing at Principality Stadium
Carmarthen Quins coach Richard Kelly believes it is an exciting time to be part of the Scarlets region as his side take on local rivals Llandovery in the SSE Swalec Cup final on Sunday, as WRU TV's Graeme Gillespie discovers
Scarlets long serving prop Phil John talks to WRU TV's Graeme Gillespie about Judgement Day IV and SSE Swalec Cup finals day. The last time Llandovery were in the cup final in 2007, the Drovers claimed the spoils with Phil playing a major role in the engine room.
Meet Aberdare coach Luke Thomas whose #FABXV nomination goes to super volunteer Daz with a whopping 10 things he does for the club each week, all except the ironing! You can also join in the search for Welsh rugby's greatest volunteers, by sending your nomination via twitter to @WRU_Community using the hashtag #FABXV
SSE Swalec Cup kings Pontypridd travelled to Swansea, fully expecting a return to their second home but Llandovery had other ideas as they also sought victory in the semi-final to earn the right to play the final at Principality Stadium