"We are delighted to welcome back Nikki Walker, James Hook, Lyndon Bateman and Jamie Nutbrown after injury, it's always good to see players returning to action and increasing the options available in the squad for a match-day. Jamie in particular is desperate to pull the shirt on again having only figured in two games for us to date, and we are excited by that prospect.
"We've selected a very experienced side, with 16 of the 22 having more than 50 Ospreys appearances to their name. We will need all of that experience for this challenge, but we are all looking forward to it immensely and hope that we'll have a big crowd behind as we look to build on last week.
"Our results have been good of late, but we feel that we can still improve in lots of aspects of our game. The players have been extremely diligent and focused this week and want to take a step closer to retaining this trophy.
"As we prepare for this game, we must congratulate our players selected for the Autumn International series this week. It is a credit to our organisation, and in particular to our players, that we can celebrate 50 per cent of the extended Wales squad coming from our regional family."
The Ospreys welcome Jamie Nutbrown, James Hook, Lyndon Bateman and Nikki Walker back from injury for the EDF Cup game, Walker back far earlier than expected.
Gavin Henson also returns from his two-match Ospreys ban, the centre eager to get game time having been named in Wales' squad for the autumn Tests.
Warriors have Matthew Jones at fly-half for a return to his old club.
The former Welsh international fly-half has recovered from an ankle injury picked up in Bucharest.
Chris Latham returns to the Worcester Warriors starting 15, replacing Loki Crighton, and is one of three changes from the team that won in Bucharest in the European Challenge Cup.
Chris Pennell comes in on the wing and Jake Abbott is in the back row replacing Miles Benjamin and Tom Wood who both have shoulder injuries.
Ospreys: Lee Byrne; Nikki Walker, Tommy Bowe, Gavin Henson, Shane Williams; James Hook, Rhys Webb; Duncan Jones (capt), Huw Bennett, Andrew Millward, Ian Gough, Lyndon Bateman, Tom Smith, Steve Tandy, Filo Tiatia.
Replacements: Richard Hibbard, Adam Jones, Alun Wyn Jones, Ryan Jones, Jamie Nutbrown, Dan Biggar, Andrew Bishop.
Warriors: Chris Latham; Rico Gear, Alex Grove, Sam Tuitupou, Chris Pennell; Matthew Jones, Ryan Powell; Matt Mullan, Aleki Lutui, Tevita Taumoepeau, Greg Rawlinson (capt), Craig Gillies, Matt Cox, Jake Abbott, Netani Talei.
Replacements: Darren Morris, Shaun Ruwers, Graham Kitchener, Rob Wood, Matt Powell, Loki Crichton, Charlie Fellows.
Referee: David Rose
Ospreys full-back Lee Byrne says they are determined to beat Group C leaders Worcester as they seek to retain their EDF Energy Cup crown.