The Blues are at home to Edinburgh with the Scottish side looking for their first win in Wales since May 2006. The Scarlets travel to Connacht, as the form team in the league, having secured 20 league points from their last six matches. They have also beaten Connacht on five of the last six meetings with the western Province.
Connacht are currently equally on points at the foot of the table with Ulster who face Irish rivals Munster at Ravenhill. The former champions have had a wretched season with only one win in their last 12 games, while Munster have won five of their last six against fellow Irish provinces.
The fifth game of the round is in Glasgow where Newport Gwent Dragons are the visitors. The Dragons win over The Scarlets last time out put some distance between themselves and the bottom two and they will be looking to build on that momentum in Scotland.
Glasgow Warriors have only once won in their eight meetings and the Dragons were the last Welsh region to win in Glasgow - back in September 2006.