The EDF Energy Cup, in its fourth year, is contested by the 12 Guinness Premiership clubs and the four Welsh Magners League regions and promises big names and great rugby as the Dragons strive for a place in the quarter-finals.
Newport Gwent Dragons Chief Executive Gethin Jenkins is looking forward to hosting rivals Newcastle Falcons following a narrow 29-24 defeat when the teams met in the same competition last season.
He said: "The tournament has been a huge success over the past three years and we look forward to some exciting clashes with our English counterparts in the pool stages of the competition.
"Hosting Newcastle Falcons at home will be a great start to the Dragons campaign and will make for an exciting occasion for the fans at Rodney Parade as we try to outclass a Newcastle Falcons team that beat us narrowly last time round.
"The Dragons have been training extremely hard so far this summer for what I'm sure will be a competitive and thrilling season ahead."
EDF Energy Cup Tournament Director Terry Burwell said: "The EDF Energy Cup has provided some fantastic rugby over the last three years and we are anticipating more this season."